Navigation Links
In vitro models will minimize animal use in arthritis studies
Date:10/17/2007

COLUMBIA, Mo. Its hard to think of scientists in laboratories working toward solutions for medical problems without mice or other laboratory animals, but animals roles in at least one major research laboratory may soon be minimal.

Researchers at the University of Missouri-Columbia's Comparative Orthopaedic Laboratory (COL) have developed an in vitro model using small sections of joint capsule and cartilage typically discarded that mimics arthritic joints. This "joint in a test tube" model can be used to investigate causes and mechanisms for the development and progression of arthritis and to screen new treatments such as pharmaceuticals. The MU research team which developed this model has shown that the results have valid and direct clinical implications for arthritis in dogs and humans.

Often, clinical research is limited by patient numbers, accessibility to appropriate samples and ethical considerations. Using in vitro models eliminates some of these barriers and allows researchers to better understand of the diseases development, characteristics and responses to various injuries, treatments and loads. The in vitro model acts similar to an actual joint with the same histological, biochemical and molecular changes.

These in vitro models will allow us to perform our research without using animals while still accurately mimicking situations in real life, said James Cook, professor of veterinary medicine and surgery and the William C. Allen Endowed Scholar for Orthopaedic Research. We can screen new drugs for arthritis in a more efficient and cost-effective way such that real progress is achieved more quickly.

The in vitro models allow for all of the tissue in a normal joint to be "grown" together such that the different types of tissues can "communicate" as they do in the actual joint. COL researchers have shown that this system maintains the tissues' appearance, composition, and function so that they react to health and disease as they would in real life. The system then allows drugs, nutritional supplements and even exercise regimens to be tested on the in vitro model.

For example, scientists can determine the effects of pressure to the joints after running or walking using a bioreactor, a device which loads the tissues in the "test tube" environment. Using this new model, MU researchers will unlock clues, on a molecular level, as to why recovery is important in healthy athletes as well as people with arthritis.

Using the joints in the test tubes will allow for greater flexibility when studying arthritis, Cook said. We can test literally hundreds of different loads on joints in a single day and show results in real time. It is strengthening our research as we are able to explain data on a molecular level and then translate it to what happens to people and pets that struggle with arthritis every day.

These in vitro models also provide a much safer mechanism for investigating new drugs and therapies. If severe side effects occur, all we have do is assess what has happened to the tissues rather than trying to treat a laboratory animal or a patient with an adverse reaction.


'/>"/>

Contact: Christian Basi
BasiC@missouri.edu
573-882-4430
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Functional Taste Cells Cultured In Vitro
2. Alcoholism Drug Vivitrol Approved By FDA
3. Scientists Create Live Birth Using Artificial Sperms Produced In Vitro
4. Chinas Neusoft and Trivitron Plan to Set up Medical Equipments Unit
5. HPV Could Hamper Success Rates of In Vitro Fertilization
6. In Vitro Treatment Only When Both Partners Agree, Rules European Court
7. Questions Raised Over Safety of In-vitro Fertilization
8. Womens Self-Esteem Not Lowered By Seeing Ultra Thin Models
9. Mouse Models To Determine The Cause Of Aggressive Leukemia
10. Spanish Fashion Show Rejects Five Models as too Thin
11. Academy for Eating Disorders Calls for Ban on Underweight Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... DMG Productions, producers of the ... in an upcoming episode, slated to air fourth quarter 2017. Check your local ... Group; a company committed to supporting dentistry using the most technologically advanced restorative ...
(Date:8/19/2017)... , ... August 18, 2017 , ... ... Administration Reauthorization Act of 2017, legislation that provides for greater public access to ... moderate hearing loss to access OTC hearing aids without being seen by a ...
(Date:8/19/2017)... (PRWEB) , ... August 19, 2017 , ... ... with contemporary illustrations of breastfeeding mothers. These illustrations show the diversity of ... in prints in a wide range of sizes. These illustrations are also available ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners of ... location as an interventional pain management physician. He brings a wealth of pain ... migraine headaches, and significant experience in spinal cord stimulation for chronic pain. , ...
(Date:8/18/2017)... , ... August 18, 2017 , ... More than 20,000 ... Republic of Congo (DRC) thanks to an ambitious venture that conjoined the passions of ... the generous support of the Liberty community. These shoes will save lives from the ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired ... Lakewood, Colorado . The reputable clinic will ... , PT, DPT with his staff of four clinicians. Lipkin ... Pittsburgh and brings over 10 years of experience with a ... Belmar PT marks the 10th PRN clinic in and around ...
(Date:8/7/2017)... 7, 2017 Diplomat Pharmacy, Inc. (NYSE: ... as president, effective Aug. 7, 2017. ... to pursue other interests and will serve as president emeritus ... has served us in multiple leadership roles since he joined ... 2015 and has provided decisive, strategic leadership which continues to ...
(Date:8/3/2017)... , Aug. 3, 2017  Opioid addiction and other ... up healthcare costs and threatening outcomes, were problems taken ... and IVD industry that support them, met this week. ... researcher said that drugs of abuse, procalcitonin and acute ... at the organization,s 69th meeting in San ...
Breaking Medicine Technology: