Navigation Links
In time for spring, biologist illuminates how seedlings regulate growth
Date:4/21/2011

PROVIDENCE, R.I. [Brown University] With seedlings and shoots still poking their leafy tops out of the soil, it's hard to read the newly published research of Brown University biologist Alison DeLong without musing that it provides a deeper understanding of what puts the spring in spring.

DeLong's paper, published in advance online April 21 in PLoS Genetics, reveals fertile new insights into the intricate network of proteins that controls plant growth and development, particularly at the seedling stage. But the research also runs deeper than the roots of any of the Arabidopsis thaliana specimens in her lab. The central enzyme in DeLong's investigation, protein phosphatase 2A (PP2A), operates in a wide variety of organisms, including in people, where it is associated with tumor growth. PP2A's universal role in life is to cleave a phosphoryl group off a protein to affect how it will function.

"Everybody has reversible protein phosphorylation," said DeLong, associate professor of biology in the Department of Molecular Biology, Cell Biology and Biochemistry. "It's a question of how an organism regulates the dephosphorylation reaction. You need to do that correctly in order to regulate growth correctly."

Striving for the light

In A. thaliana, what DeLong wanted to discover about PP2A was how it regulates the production of ethylene, a gaseous hormone that inhibits the elongation of plant cells. As a plant embryo germinates, cells in the emerging shoot elongate to reach above the soil. Its goal is to reach daylight so that photosynthesis can begin before the reserve of food in the seed runs out. PP2A's job is to keep a lid on ethylene production during germination.

"Keeping these ethylene levels low is actually quite critical during this phase of growth," DeLong said.

In a series of experiments comparing normal A. thaliana plants to those with mutations that disabled PP2A and other proteins, DeLong and and graduate student Kyle Skottke, the lead author, found the mechanism by which PP2A works. In seedlings, its phosphoryl-pruning effect suppresses the activity of a protein called ACS6 that is necessary to produce ethylene. In Petri dishes kept in the dark analogous to growing underground plants lacking a PP2A gene grew much shorter shoots than normal plants.

Unexpectedly, the team, including researchers from the University of North CarolinaChapel Hill, also found that PP2A boosts the activity of a second class of ACS proteins. Those proteins are responsible for maintaining the normal baseline production of ethylene, which is important to have around at other developmental stages.

"For us the fun part of the story is that we went looking for the answer to a single question and then, in walking through the analysis to lead us to that single answer, we actually found a second phenomenon that we hadn't known to look for," she said.

A next step in DeLong's lab will be to look at how the protein network operates during later developmental stages. With spring settled, so to speak, the growing season is the next focus of her inquiry into the nature of growth.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Related medicine news :

1. In Vitro Fertilization Success Rate Higher in Spring, Study Suggests
2. Tufts biologists find another clue to the origins of degenerative diseases
3. MIT biologists pinpoint a genetic change that helps tumors move to other parts of the body
4. Biologists discover control center for sperm production
5. National Academy of Sciences honors microbiologists for major scientific contributions
6. Biologists, educators recognize excellence in evolution education
7. Caltech biologists discover microRNAs that control function of blood stem cells
8. U. Iowa biologists publish findings on cell interactions
9. Physicists help biologists to understand protein folding
10. Discovery of Stem Cell Illuminates Human Brain Evolution, Points To Therapies
11. New tool illuminates connections between stem cells and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... , ... Technique, technique, technique – with a dash of common sense. Those ... and exercise or simply lifting heavy objects, advises Dr. Kaliq Chang, interventional pain management ... says. “Improper technique in lifting anything heavy or an attempt to lift too much ...
(Date:5/23/2017)... City (PRWEB) , ... May 23, 2017 , ... ... Population Health and Clinical Integration company, announced today that its iClinic V12.2 ... Home (PCMH) 2017 Prevalidation. NCQA recently introduced PCMH 2017 standards which emphasize ...
(Date:5/23/2017)... ... 2017 , ... Allegheny Health Network and the Alexis Joy ... Women’s Behavioral Health at West Penn Hospital , a unique facility that will ... pregnancy-related depression. Construction of the Center is underway with a scheduled opening in ...
(Date:5/23/2017)... ... May 23, 2017 , ... Cambridge, MA, ... steady since 2009, according to a Workers Compensation Research Institute (WCRI) study, a ... the North Carolina System: CompScope™ Benchmarks, 17th Edition looks at indemnity and ...
(Date:5/23/2017)... ... May 23, 2017 , ... i2i Population Health, a ... KLAS category winner, has named Daniel P. Bullington as chief technology officer. , ... platform and product offerings,” says Justin Neece, president. “Daniel is an excellent fit ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017  Semler Scientific, Inc. (OTCQB: SMLR), an ... improve the clinical effectiveness and efficiency of healthcare ... quarter ended March 31, 2017. ... to identify when preventive care options are appropriate, ... heart attacks or strokes occur," said Doug ...
(Date:5/6/2017)... SKANEATELES FALLS, N.Y. , May 5, 2017 /PRNewswire/ ... expansion that will add approximately 100,000 square feet to ... announced in September 2016 its commitment to bring more ... York , where Welch Allyn has maintained a ... facility will help accommodate these new positions, a large ...
(Date:5/4/2017)... Israel , May 4, 2017  DarioHealth Corp. ... mobile health and big data solutions, today announced that ... A&D Company, and STI Technologies Limited to lower diabetes ... immediately. Through STI,s innoviCares card, which is available throughout ... , DarioHealth customers will be eligible for additional savings ...
Breaking Medicine Technology: