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In the real life setting, boosted REYATAZ proves as effective in women living with HIV as men
Date:7/20/2011

(ROME, 20 July 2011) Bristol-Myers Squibb Company announced results from a long-term, retrospective, European cohort study, which included 1,294 antiretroviral (ARV)-experienced patients (336 female and 958 male) from Germany, France and Sweden, that were presented today at the Sixth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011).

In a gender-specific sub-analysis, boosted REYATAZ (atazanavir sulphate) (ATV/ritonavir)-based regimens demonstrated no difference in time to virologic failure in women compared to men over a follow-up period of up to five years.2

Approximately 30 years into the AIDS epidemic, nearly 16 million women are living with HIV, and most of them are of childbearing age.3 HIV has become the leading cause of disease and death among women of reproductive age worldwide.4 In Europe, women account for 35% of new HIV diagnoses.1 However, data on efficacy, safety and tolerability on antiretrovirals (ARVs) in women are limited, as they are under-represented in clinical trials.5

"More clinical data, especially long-term data, evaluating ARV response in women with HIV are needed to improve their management; in this way, the results presented today give us as physicians relevant and valuable information," said Prof. Dr Norbert H. Brockmeyer, Germany.

This retrospective, observational study collected data from three European databases (France DatAids; Germany KompNet; Sweden InfCare). All participants were ARV-treatment experienced patients; 336 female (median age of 40 years) and 958 male (median age of 44 years).2 The present sub-analysis evaluated the effect of gender on long-term outcomes of ATV/r-based regimens.

The results revealed no gender-based differences in time to virological failure, defined as two consecutive HIV RNA ≥ 50 c/mL or one HIV RNA ≥ 50 c/mL followed by discontinuation. After three years of follow-up, the probability of not having virolo
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Contact: Joanna Ritter
33-015-883-6509
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Source:Eurekalert

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