Navigation Links
In the quest for safer treatment for systemic lupus erythematosus
Date:6/17/2014

This news release is available in Spanish.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. It can affect various organs, in particular, the skin, joints and kidneys although it displays great variability in extent and seriousness depending on the patient. Approximately nine out of every ten patients are female and it appears in one woman in every thousand.

As Dr Guillermo Ruiz-Irastorza, head of the Autoimmune Disease Research Unit of the Hospital Universitario Cruces, explained, traditionally lupus has been treated mostly with glucocorticoids (prednisone), despite the fact that its severe side effects have been known for years. "We doctors knew that administering high doses of prednisone in an ongoing way caused irreversible damage like osteoporosis, avascular necrosis of bone, diabetes or cataracts. However, the tendency was to accept these side effects as an inevitable price to pay in exchange for controlling the disease".

Yet recent studies by this same group indicate that lower doses of glucocorticoids could be just as effective. What is more, in more serious forms, pulsed therapy, in other words, the intermittent intravenous administering of high doses is highly effective and probably does not lead to so many adverse effects.

So the researchers at the Hospital Universitario Cruces decided to study the relation between treatment with prednisone administered orally over 4 years from the moment of diagnosis and the damage built up over the first 5 years. To complete the study, they also looked at the effect of another glucocorticoid, methylprednisolone, administered intravenously at high doses and intermittently, at the moments when the disease manifests itself with increased severity.

230 patients, 206 of whom were women, took part in the study. The average age when they were diagnosed with lupus was 35.75 years.

"We saw that by the end of the fourth year most of them, 80%, had been treated with prednisone at some point, and by the fifth year nearly 4 out of every 10, 37.8%, had developed damage," pointed out Dr Ruiz-Iraztorza. Significantly, the patients with damage had received higher doses of prednisone (10.4 mg/day as opposed to 6 mg/day in the patients without damage). In the specific study of the damage that could be directly attributed to the use of glucocorticoids, the results were similar, with average daily doses of 11 vs. 7 mg/day, respectively. And it does not stop there. As previous studies had suggested, they proved that the association with damage began with average doses of 7.5 mg/day. "In other words, above that dose, permanent side effects may appear." By contrast, pulsed methylprednisolone therapy was not associated with any kind of damage.

Anti-malarial drugs for treating lupus

The research carried out by the group at the Hospital Universitario Cruces has been published in the specialised journal Rheumatology. In fact, these results have confirmed that the guidelines used in the Auto-immune Disease unit of the Hospital Universitario Cruces for several years are good. Dr Ruiz-Irastorza stresses that the background treatment in patients with SLE has to be anti-malarial drugs, specifically hydroxychloroquine, since, as he maintains, "it has been proven that they are more effective in the long term than glucocorticoids for controlling lupus and, at the same time, they have far fewer side effects. The role of the latter needs to be restricted to managing periods during which the disease flares up."

"The beneficial effect of anti-malarial drugs on SLE was discovered by accident during the Second World War," explained the doctor. "In any case, as prolonged background treatment they were seen to be ideal for controlling lupus, even as a monotherapy in many patients with proven effects on long-time survival. So we reserve glucocorticoids to be administered when the disease flares up, and we know that in more serious cases we can administer pulsed methylprednisolone safely and effectively. For maintenance treatment, the prednisone dose must not exceed 5 mg/day so on occasions we have to add other immunosuppressive drugs. We believe that these combined guidelines that we use constitute a safer and more effective alternative for patients with SLE."


'/>"/>

Contact: Matxalen Sotillo
komunikazioa@ehu.es
34-688-673-770
University of the Basque Country
Source:Eurekalert  

Related medicine news :

1. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
2. When to have kids: A complex question for hazel dormice
3. Weirdest hCG Questions Revealed
4. New Polar RCX3 Heart Rate Monitor Versus Suunto Quest
5. Progress in quest to reduce use of radiation in treatment of pediatric Hodgkin lymphoma
6. Medtronic Infuse Bone Graft Questioned As Allegations Unfold – Bisnar
7. Chase Attorneys Offer Free Consultations
8. HCOs find risks & opportunities in quest for reduced costs & improved quality
9. Health care organizations quest for reduced costs and improved quality
10. Study questions value of calcium and vitamin D supplements
11. Study Questions Guidelines on Radiation for Older Breast Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
In the quest for safer treatment for systemic lupus erythematosus
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Remember the ... time. , According to Perry A~, author of “Calcium Bentonite Clay” the health ... key role in balancing and detoxifying the body. , A former motivational speaker, Perry ...
(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published data from ... type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels ... in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Guruji Mahendra ... 9th, 10th and 11th, 2016 in honor of his birthday on February 10th. ... happiness. Mahendra Trivedi is known by over 250,000 people from over 40 different ...
(Date:2/7/2016)... , ... February 07, 2016 , ... Women's Excellence staff, ... Wear Red Day. National Wear Red Day is the first Friday each February ... disease and stroke cause 1 in 3 deaths among women each year – more ...
(Date:2/6/2016)... CA (PRWEB) , ... February 06, 2016 , ... US ... Ultimate Coaching Conference (YUCC) . This event brings together top non-profit leaders, ultimate organizations, ... Equity and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 2016 CBG Technologies, a U.S. company, ... Recycling Systems, specifically designed for precision parts cleaning. ... and existing vapor degreasers, parts washers and ultrasonic ... continuous recycling and recovers 100% of the solvent ... --> Precision parts manufacturers benefit from this ...
(Date:2/8/2016)... Feb. 8, 2016  Neurocrine Biosciences, Inc. (Nasdaq: ... its fourth quarter and year-end 2015 results after the ... will then host a live conference call and webcast ... update Thursday afternoon, February 11, 2016 at 4:30 p.m. ... . --> http://www.neurocrine.com . --> ...
(Date:2/8/2016)... ISELIN, N.J. , Feb. 8, 2016 ... ), a medical device company focused on ... technologies, today announced today announced that it ... on Wednesday, February 17, 2015 at 9:00 ... and to discuss its corporate strategy, advancements ...
Breaking Medicine Technology: