Navigation Links
In the lab, scientists coax E. coli to resist radiation damage
Date:3/14/2014

MADISON, Wis. Capitalizing on the ability of an organism to evolve in response to punishment from a hostile environment, scientists have coaxed the model bacterium Escherichia coli to dramatically resist ionizing radiation and, in the process, reveal the genetic mechanisms that make the feat possible.

The study, published in the online journal eLife, provides evidence that just a handful of genetic mutations give E. coli the capacity to withstand doses of radiation that would otherwise doom the microbe. The findings are important because they have implications for better understanding how organisms can resist radiation damage to cells and repair damaged DNA.

"What our work shows is that the repair systems can adapt and those adaptations contribute a lot to radiation resistance," says University of Wisconsin-Madison biochemistry Professor Michael Cox, the senior author of the eLife report.

In previous work, Cox and his group, working with John R. Battista, a professor of biological sciences at Louisiana State University, showed that E. coli could evolve to resist ionizing radiation by exposing cultures of the bacterium to the highly radioactive isotope cobalt-60. "We blasted the cultures until 99 percent of the bacteria were dead. Then we'd grow up the survivors and blast them again. We did that twenty times," explains Cox.

The result were E. coli capable of enduring as much as four orders of magnitude more ionizing radiation, making them similar to Deinococcus radiodurans, a desert-dwelling bacterium found in the 1950s to be remarkably resistant to radiation. That bacterium is capable of surviving more than one thousand times the radiation dose that would kill a human. "Deinococcus evolved mainly to survive desiccation, not radiation," Cox says, "so when conditions are right, it can repair damage v
'/>"/>

Contact: Michael Cox
mcox@wisc.edu
608-262-1181
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
2. Scientists discover new protein involved in lung cancer
3. Scientists explore promising new option for first line of attack in lymphoma
4. Tel Aviv University scientists honored for proposals in melanoma research
5. Scientists call for screening mammography every 2 years for most women
6. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
7. Scientists develop powerful new animal model for metastatic prostate cancer
8. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
9. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
10. NCCS scientists discover gene regulation is dependent on protein ANP32E
11. Scientists make your stomach turn bright green if you have an ulcer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Coco Libre announced today that ... and VIPs at the 2015 Vans US Open of Surfing, July 25 through August ... claim “no added sugar” on the market, is a natural choice given the Open’s ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source ... to catch a new and refreshing show on Broadway, look no further than Hamilton. ... an Obie Award, Outer Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to an article published ... if they could reach a consensus on the steps that need to be taken ... group reached 90 percent consensus on a series of steps that each surgeon must ...
(Date:7/31/2015)... (PRWEB) , ... July 31, ... ... Jason T. Brown’s live lecture on pharmaceutical negligence is now available online ... was well received with a 94% approval rating from the nationwide audience. ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... As part ... believes community involvement and support of animal welfare organizations is essential to the longevity ... third consecutive year in the National Association of Professional Pet Sitters (NAPPS) annual Presents ...
Breaking Medicine News(10 mins):Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4
... TUESDAY, Jan. 31 (HealthDay News) -- Many employers in the ... disabilities due to preconceived ideas that they can,t do the ... non-disabled workers, a new study contends. University of New ... United States and found similar concerns related to the hiring ...
... ANN ARBOR, Mich. A mutant protein found in nearly ... cancer,s development but in its continued growth, according to a ... The finding suggests a possible target for developing new ways ... mutations in the Kras gene are what cause pancreatic cancer ...
... researchers at the University of Exeter Peninsula College of Medicine ... pressure between arms could be a useful indicator of the ... add support to the calls for both-arm blood pressure checks ... in The Lancet online today (30th January) and ...
... Randy Dotinga HealthDay Reporter , THURSDAY, Jan. 26 ... molecular test can provide insight into whether patients are at ... form of lung cancer. The test, which is ... undergo chemotherapy to prevent the cancer from returning. There ...
... An itch is just an itch. Or is it? ... at Wake Forest Baptist Medical Center and a world-renowned itch ... related to the itch,s location. While previous studies by ... relief at different body sites and related pleasurability had not ...
... (HealthDay News) -- Positive reinforcement, such as receiving small, ... seems to help patients with high blood pressure take ... of black Americans. The findings are significant because ... and death, the researchers from the Center for Healthful ...
Cached Medicine News:Health News:Hospitality Not a Friendly Industry for Disabled Workers: Study 2Health News:Gene linked to pancreatic cancer growth, U-M study finds 2Health News:2-arm blood pressure check indicator for risk from heart disease or death 2Health News:Test Might Predict Risk of Lung Cancer's Return 2Health News:Body location plays part in scratching pleasure 2Health News:Positive Reinforcement May Help Patients Take Their Meds 2
(Date:7/31/2015)... 31, 2015 Egalet Corporation (Nasdaq: ... company focused on developing, manufacturing and marketing innovative ... previously announced underwritten public offering of 7,666,667 shares ... price of $11.25 per share. The shares of ... issued upon the exercise in full by the ...
(Date:7/31/2015)... Magnaquest, a leading Subscription ... cloud computing operators has signed a Proof of ... Internet of Things (IoT) related initiative. The PoC ... model.      (Logo: http://photos.prnewswire.com/prnh/20140807/700645 ) ... business innovations to make healthcare services more accessible ...
(Date:7/30/2015)... 2015  ResMed Inc. (NYSE: RMD ) today ...  Revenue for the quarter was $453.1 million, a 9 ... 2014 (a 17 percent increase on a constant currency ... quarter ended June 30, 2014.  Diluted earnings per share ... ended June 30, 2014.  The results ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16
... Maine, Jan. 13, 2011 Puritan Medical Products ... swabs and applicators in North America, has announced ... performance flocked products. The new HydraFlock ™ and ... with extremely rapid release performance. Both ...
... U.S. Marshals, acting under a court order sought ... 5 and 6, seized all dental devices from Rite-Dent ... (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) The seizure ... inspection that found significant deficiencies in the company,s manufacturing ...
Cached Medicine Technology:Puritan Medical Products Introduces New Patent Pending Flocked Swab Technology 2U.S. Marshals Seize Dental Devices From Florida Manufacturer 2
Bone cement with Gentamicin 2.5%....
... Techno-Aide provides the highest level of ... quality lead protective eyewear. Consistent ... tolerance allowed. Mfg supervised by Licensed ... lens meet or exceed standards for ...
... fit large designer goggle includes ... bridge providing a more comfortable, ... nose. The head strap design ... fit. The acrylic side shields ...
... steel base metal with gold electro-plate, the ... Includes adjustable non-slip silicon nose pads for ... custom fitted lead sheet side shields that ... for increased scatter radiation protection. (Temples on ...
Medicine Products: