Navigation Links
In the Forefront of Research into Protein Folding and Macromolecular Complex Assembly
Date:12/4/2007

accumulate in the joints of dialysis patients and which are associated with dialysis-related amyloidosis. A detailed understanding of these processes at the molecular level will aid in the design of therapeutics.

New Form of Mass Spectrometry Giving New Dimensions to Biological Research

As a tool, conventional mass spectrometry is an excellent method for differentiating between proteins having different masses. However, as different conformers, or folded forms, of a particular protein have identical masses, it is virtually impossible to differentiate them by conventional means. That's where the Waters SYNAPT HDMS System, and its embedded ion mobility technology, has helped the University of Leeds.

"A protein can fold into a very compact 3-D structure or under certain conditions it can unfold into a more expanded structure. Even though these different 3-D structures have the same mass and mass-to-charge (m/z) ratio, the ion mobility capability of the SYNAPT HDMS System can separate them and tell you how much of the protein is in its folded form vs. the unfolded form. And as the cross-sectional areas of the two protein conformers are different, by being able to separate them by shape, the SYNAPT HDMS System allows us to distinguish between the various protein forms. The results are really amazing," says Dr. Alison Ashcroft, Reader in Biomolecular Mass Spectrometry and Mass Spectrometry Facility Manager.

The SYNAPT System from Waters has provided the lab with new insights into the assembly process. "It's adding a new dimension to our research. We can now quantify the amount of protein that is in its native state and the amount that is unfolded and partially folded. We can also monitor which particular conformers are consumed during the assembly process. This is providing important new insights and detail into how biomolecules work at the molecular level," adds Dr. Ashcroft.

Waters introduced the SYNAPT HDMS System at the American Soci
'/>"/>

SOURCE Waters Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Responsible Family Company Aims to Bring Responsibility to the Forefront of Every Caregivers Mind
2. Stanford researchers find culprit in aging muscles that heal poorly
3. Children of depressed moms do better when dad is involved, SLU researcher finds
4. UCLA researchers identify markers that may predict diabetes in still-healthy people
5. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
6. New research shows how chronic stress worsens neurodegenerative disease course
7. New research explores newborn in-hospital weight loss
8. Research may unlock mystery of autisms origin in the brain
9. Bipolar disorder relapses halved by Melbourne researchers
10. HIVs impact in Zimbabwe explored in new research
11. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... growth factor receptor (EGFR) mutations found in the circulating ... non-small cell lung cancer (NSCLC) patients correlates well with ... EGFR tyrosine kinase inhibitor (TKI) therapy is approved for ... the standard for determining mutation status is with DNA ... or not available. A more abundant and less invasive ...
(Date:8/22/2014)... NV (PRWEB) August 22, 2014 ... Dr. Sen and Dr. Samantha Pearson to help people ... and avoid corrective vision surgery by instead improving their ... prompting an investigative review. , “There’s a reason ... dollars in revenue each year—it’s because people just assume ...
(Date:8/22/2014)... Chicago, IL (PRWEB) August 22, 2014 ... become a thriving fertility destination, and now offers the ... interdisciplinary team of infertility specialists. The fertility network of ... an overall commitment to world-class reproductive care, female and ... program lives up to the standards so eminently set ...
(Date:8/22/2014)... August 22, 2014 The improved access ... specifically in the developing world, has led to the ... number of deaths due to AIDS globally. However, despite ... number of new patients becoming affected by the virus ... being undertaken by all related organisations and stakeholders, by ...
(Date:8/22/2014)... August 22, 2014. A new study of ... with multiple sclerosis (MS) may be able to ... study was epublished ahead of print on July ... Genova, Hali Griswold, Nancy D. Chiaravalloti & John ... with multiple sclerosis doi: 10.3233/NRE-141113). Self-awareness is one,s ...
Breaking Medicine News(10 mins):Health News:High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2
... Reinberg HealthDay Reporter , TUESDAY, Feb. 7 (HealthDay News) ... a new "universal" influenza vaccine: one that might be effective against ... year, as now happens. "Our hope is to develop a ... subtypes so we won,t need to keep making new flu vaccines ...
... Repeat cases of shingles may be more common than suspected, ... people only get shingles once in a lifetime. People ... severe pain. The condition is caused by the herpes zoster ... Minn., analyzed the medical records of nearly 1,700 patients, aged ...
... Wiley-Blackwell, the Scientific, Technical, Medical, and Scholarly (STMS) publishing ... 42 new titles to its journals program in 2011, ... collaboration with societies or other organizations. Beginning ... Wiley Online Library, offering the latest, peer-reviewed research in ...
... a new and unusual "app" for the smart phone: tracking air ... and preventive medicine, has received a grant to assess a person,s ... this case, the City of Buffalo. The study is ... Health (NIH). A city,s air pollution varies from downtown ...
... associated with higher risks of obesity, heart disease, diabetes, and ... In a ground-breaking new study published in the Feb. ... from University Hospitals (UH) Case Medical Center and Case Western ... less than six hours of sleep at night had an ...
... Mich. Without fanfare, hundreds of thousands of children ... usually to alleviate recurring infections and obstructive sleep problems. ... to a pathologist, who looks for evidence of more ... common practice may not be cost-effective because those additional ...
Cached Medicine News:Health News:'Universal' Flu Vaccine Shows Promise in Early Trial 2Health News:'Universal' Flu Vaccine Shows Promise in Early Trial 3Health News:Shingles Returns More Often Than Thought 2Health News:Over 40 new titles added to Wiley-Blackwell's journals program in 2011 2Health News:New study to use smart phones to track air pollution exposure 2Health News:Lack of sleep found to be a new risk factor for colon cancer 2Health News:The great tonsil dilemma 2Health News:The great tonsil dilemma 3
(Date:8/21/2014)... 21, 2014  eRelevance Corporation ( www.erelevancecorp.com ), ... that it has completed integration with Nextech, a ... Surgery and Dermatology practices. "Integration allows ... healthcare practices using Nextech," stated Bob Fabbio ... information from the EMR we are able to ...
(Date:8/21/2014)... , Aug. 21, 2014 /CNW/ - Eisai Limited is ... introduction of the first-of-its-kind comic book available in ... has been designed specifically to educate children and their parents ... Canada affecting more than 300,000 Canadians. Eisai is ... care (hhc) , in which the patient is central – ...
(Date:8/21/2014)... CHARLOTTE, N.C. , Aug. 21, 2014 /PRNewswire-iReach/ ... Home Medical Equipment, Inc. for the third straight ... annual Inc. 500|5000, an exclusive ranking of the ... most comprehensive look at the most important segment ... Yelp, Pandora, Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, ...
Breaking Medicine Technology:eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3
... important treatment option for more vulnerable populations , ... showed that pitavastatin is an effective treatment for the ... safety and tolerability profile to low-dose pravastatin. The ... the XV International Symposium on Atherosclerosis in Boston. , ...
... was found to be prevalent in cancer patients regardless of ... conducted at Cancer Treatment Centers of America ... screening for vitamin D deficiency and aggressive vitamin D repletion ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20090612/CTCALOGO ) , ...
Cached Medicine Technology:Study Demonstrates Efficacy of Pitavastatin in Elderly Patients 2Study Demonstrates Efficacy of Pitavastatin in Elderly Patients 3Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients 2
Solid 4 mm blades. Locking thumb. Dull finish. Holes in bar decrease weight of speculum....
Open 14 mm blades with 6 mm lifting wings. Dull finish....
Open 10 mm blades. Dull finish....
Open wire style 16 mm blade with a wing tip twist giving the surgeon better on-axis accessibility....
Medicine Products: