Navigation Links
In search of cancer's common ground: A next-generation view
Date:3/3/2011

Researchers have synthesized the vast literature on cancer to produce a next-generation view of the features that are shared amongst all cancer cells. These hallmarks of the disease provide a comprehensive and cohesive foundation for the field that will influence biomedical researchers in their quest for new cancer treatments.

The review article by Douglas Hanahan of cole Polytechnique Fdrale in Switzerland and Robert Weinberg of the Whitehead Institute for Biomedical Research appears in the March 4th issue of Cell, a Cell Press publication. The new article updates and expands on the authors' classic review, "Hallmarks of Cancer," the most cited Cell article of all time.

"To our knowledge there has been no such synthesis for another disease," Hanahan said. "What was special for cancer was the explosion of knowledge, daunting in its scope and detail, but sufficient in terms of mechanistic pieces of a puzzle, to allow such a formulation."

"Cancer is special because it is, conservatively, more than 100 distinct diseases," Weinberg added. "The question is whether one can find commonalities shared by this motley crew."

The approach, as Hanahan and Weinberg explain it, was to stand back and attempt to produce some overarching conceptual scaffold, imposing some order on the vast and seeming unmanageable flood of observations and conceptual models that had poured out of the cancer field since the discovery of the first oncogene in the 1970s. The original "hallmarks" or functional abilities that characterize cancer include: 1) self-sufficiency in growth signals, 2) insensitivity to anti-growth signals, 3) tissue invasion and metastasis, 4) limitless replicative potential, 5) sustained blood vessel growth (angiogenesis), and 6) resistance to cell death.

As the new work details, much has been revealed in the last decade about the molecular and genetic underpinnings of these six original hallmarks. The authors also introduce two enabling hallmarks -- genomic instability and inflammation and two emerging hallmarks evasion of the immune system and reprogrammed energy metabolism.

Enabling characteristics set the stage for cancer, Hanahan explained. Genomic instability results in rare mutations that contribute to the regulation or functional mechanics of cancer's acquired capabilities. Inflammation of tumors mistaken for wounds by the immune system brings in wound-healing cells that inadvertently encourage proliferation, angiogenesis, and invasion.

Emerging hallmarks, on the other hand, are features that are beginning to appear as though they may be core features in nearly all cancers based on recent evidence. "While not yet clearly documented to be widespread or ubiquitous in cancers, they may well become so over the coming years," Weinberg said.

Understanding these principles has implications for cancer treatment.

"Drugs targeting each discrete hallmark or enabling characteristic are either clinically approved or are in clinical development, but virtually all show limited benefit due to the development of resistance," Hanahan said. "We pose the reasonable - but far from certain - hypothesis, that by co-targeting multiple hallmarks, drug resistance may be more difficult for a cancer to achieve, thereby producing more enduring clinical benefits for cancer patients."

Ultimately, though, it all comes down to one simple notion: "As before, we believe that there is much to be gained from stepping back and understanding the basic principles of cancer biology rather than burrowing deeply into its myriad details," Weinberg said.


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Nationwide Video Search Kicks off Ban Asbestos Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... , ... Donna Parker, L. Ac. reads all sorts of books on ... be very practical. She wanted to write a guide/workbook that would give readers step-by-step ... prompted her in writing “ A Clear Path to a Vibrant Life : 7 ...
(Date:4/24/2017)... ... April 24, 2017 , ... A new ... the last decade, student well-being has seriously declined. "When disenfranchised youth from the ... join the Islamic State to turn the historic multi-ethnic and multi-religious powerhouses of ...
(Date:4/24/2017)... ... ... “Reflections of God’s Work”: an enlightening collection of life lessons leading each person ... author, Jerri Broglin, a survivor of great loss who gained insight on how to ... those searching for answers, as we are finding the answers that are so deep ...
(Date:4/24/2017)... ... April 24, 2017 , ... “Learning to Use Your SPIRITUAL COMPASS To Navigate ... Use Your SPIRITUAL COMPASS To Navigate Life Issues” is the creation of published author, ... the Board of Directors for CONTACT USA, and former member of the American Association ...
(Date:4/24/2017)... ... ... “The Saint with Trin, and Omega Station”: a triple feature offering nonstop ... published author, Chris Jackson. Chris Jackson grew up in Abilene, Texas. He ... District teaching English. He is heavily involved in the youth group of his local ...
Breaking Medicine News(10 mins):
(Date:4/21/2017)... , April 21, 2017 Halo Labs ... throughput biopharmaceutical particle analysis system called the Horizon at ... May 1st. The new system analyzes sub visible particulate ... time rapid particle screening as early as candidate selection ... with leading biopharma contract research organization Elion Labs ...
(Date:4/20/2017)... -- Cogentix Medical, Inc. (NASDAQ: CGNT), a global medical ... and Gynecology markets with innovative and proprietary products, ... Company as Senior Vice President, Marketing & Business ... will report directly to Darin Hammers , ... delighted that Ash has joined the Cogentix team," ...
(Date:4/20/2017)... April 20, 2017  Vivify Health, the pioneer and ... been awarded a very significant patent for the advancement ... continual care via digital health.  This landmark patent provides ... and further secures Vivify,s position as the leader in ... was the first company to apply consumer mobile devices, ...
Breaking Medicine Technology: