Navigation Links
In fight against cancer, a closer look at nuclear blebbing
Date:2/19/2013

smooth and maintains an overall spherical shape, but abnormal nuclear shapes characterized by blebs have been observed in the cells of people suffering from some forms of cancer and other diseases.

In mammals, the lamin meshworks that make up the nuclear lamina consist of mainly two types of lamin proteins, known as types A and B, which are wrapped like two nets around the nucleus. Under normal conditions, the A-type and B-type lamins co-exist throughout the sphere, creating a healthy lamina of approximately even thickness throughout.

But when one of the B-type lamins is depleted, researchers found the A-type and B-type lamins begin to segregate from one another, resulting in an uneven mesh layer with altered mechanical properties. In some regions, the lamina's fibers begin to gap and separate, giving rise to nuclear blebs, bulges in the cell's nuclear envelope.

The nuclear lamins, especially the A-type lamins, are now considered to be major building blocks of nuclear architecture and are thus involved in numerous important nuclear functions. Much of the recent information on the functions of the nuclear lamins comes from findings demonstrating that many different human diseases are caused by hundreds of mutations in the nuclear lamin A gene. Many of these diseases are accompanied by changes in nuclear shape and altered lamin organization.

"This study helps us to begin to understand how these abnormal shapes are formed," said Robert D. Goldman, the Stephen Walter Ranson Professor of Cell and Molecular Biology, chair of the department of cell and molecular biology at the Feinberg School, and one of the paper's authors. "Collaborations between physicists and cell biologists are beginning to reveal new insights into these normal and abnormal cells."

Enabling some of those new insights, the Northwestern researchers designed an energy-minimizing continuum elastic model that enabled them to produce structures with comparable
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Research Foundation for Tick-Borne Infections Fights Lyme Disease, Babesiosis and Encephalitis with Pilot Studies
2. Combo of Avastin, second drug shows promise fighting brain cancer, Mayo Clinic finds
3. Report Calls for Better U.S. Efforts to Fight Counterfeit Drugs
4. New hope in fight against multi-resistant germs
5. WeightLossApp.com: The Skinny: Fighting Obesity in the Workplace Through an Innovative Mobile Application
6. Tiger Schulmann's MMA Student, Uriah Hall, Debuts on The Ultimate Fighter
7. Scientists Explore How Zinc Fights Off Infection
8. Electrical Brain Stimulation Plus Drug Fights Depression: Study
9. Tree-Savers™ Reports Successful Launch of Private St Beetle Lab; 100,000 Predator Beetles Now Available to Fight HWA Infestation
10. Scientists identify new strategy to fight deadly infection in cystic fibrosis
11. Bacterial supplement could help young pigs fight disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... 2015 Indiana Fiber Network, LLC (IFN), ... Computer Services, Inc (BCS) has selected IFN as a ... “The technology, service, and working relationship with IFN has ... local feel you get with IFN. I like ... makes local decisions and operates as a local community ...
(Date:5/3/2015)... (PRWEB) May 03, 2015 SpineFrontier, a ... from the FDA to produce and market their new ... can be used in outpatient settings and is compatible ... alternate posterior approach has been extensively researched and refined ... approval to use this approach in conjunction with a ...
(Date:5/2/2015)... May 02, 2015 Ticket Down has secured ... for the long awaited event today, Saturday, May 2nd at ... boxing fans will be able to secure tickets for both ... fight that boxing fans have wanted for more than five ... Floyd “Money” Mayweather will step inside the ring to fight ...
(Date:5/2/2015)... New York, NY (PRWEB) May 02, 2015 ... – when a deadly natural disaster strikes anywhere on ... ways to leverage human sympathy and compassion for their ... US-CERT (United States Computer Emergency Readiness Team) issued ... warning users “of potential email scams citing the earthquake ...
(Date:5/2/2015)... 02, 2015 Kare Visits LLC. launched in ... busy caregivers. Kare Visits offers relief for caregivers by ... facilities. According to the Caregiver Action Network, eight ... of 20 hours a week caring for an elderly or ... to hire a nurse, a caregiver is now empowered to ...
Breaking Medicine News(10 mins):Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 3Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2
... ... CradlePoint MBR1200 Router makes instant Internet access simple for small or remote offices; CradlePoint ... ... 10, 2010 -- Sprint (NYSE: S) has certified CradlePoint’s MBR1200 Failsafe Gigabit N Router ...
... finds , MONDAY, May 10 (HealthDay News) -- Smoking tobacco ... and those most likely to indulge are privileged young men ... , Young adults in Montreal who use water pipes, or ... away from their parents and have a higher household income ...
... A study by researchers from the Georgetown ... (GUMC) identifies a potential new combination therapy to "rescue" ... cancers. The findings were published on May 15, ... Therapeutics . Fulvestrant is a common second-line therapy ...
... Flavour is literally the spice of life and for ... would be unthinkable. Yet just this aspect of everyday ... developing abnormal eating behaviours including changes in food preferences, ... evidence that these behaviours are linked to a loss ...
... learn, seem to help later on, study suggests, , ... fed directly from the breast in early infancy tend ... counterparts, new research suggests. , This kind of self-regulation ... has found that breast-feeding protects against obesity. , ...
... ... Price and Dr. Donald Hensrud of Mayo Clinic are scheduled as keynote speakers at ... Atlanta, Georgia. , ... Florham Park, NJ (PRWEB) May 10, 2010 -- DTC Perspectives, Inc ., the ...
Cached Medicine News:Health News:CradlePoint Router and Mobile Broadband Adapter Pair With Sprint 4G to Create Instant Offices, Business Continuity Solutions 2Health News:CradlePoint Router and Mobile Broadband Adapter Pair With Sprint 4G to Create Instant Offices, Business Continuity Solutions 3Health News:CradlePoint Router and Mobile Broadband Adapter Pair With Sprint 4G to Create Instant Offices, Business Continuity Solutions 4Health News:CradlePoint Router and Mobile Broadband Adapter Pair With Sprint 4G to Create Instant Offices, Business Continuity Solutions 5Health News:CradlePoint Router and Mobile Broadband Adapter Pair With Sprint 4G to Create Instant Offices, Business Continuity Solutions 6Health News:Hookahs an Unhealthy Hit Among Privileged Young Adults 2Health News:Hookahs an Unhealthy Hit Among Privileged Young Adults 3Health News:Researchers discover new way to 'rescue' treatment sensitivity of breast cancer cells 2Health News:Dementia takes away the meaning of flavors 2Health News:Breast-Fed Babies Know When to Say When 2Health News:Breast-Fed Babies Know When to Say When 3Health News:Dr. Kessler, Congressman Price & Mayo Clinic Headline Inaugural MDPA Conference 2Health News:Dr. Kessler, Congressman Price & Mayo Clinic Headline Inaugural MDPA Conference 3
(Date:5/1/2015)... and Markets ( http://www.researchandmarkets.com/research/pjbxjd/us_aco_it ) has announced ... Outlook 2018" report to their offering. ... ACO would grow at a CAGR of 22% during ... has been studied on three main grounds viz. spending ... Our research provides current market estimation and forecast till ...
(Date:5/1/2015)... , May 1, 2015 At the American ... in Washington D.C. , Elekta will ... that enables clinicians to leverage the enormous amount of ... treatments conducted each year – to advance clinical research ... Registry is a cloud-based solution that allows practitioners to ...
(Date:5/1/2015)... , May 1, 2015 The Institute for ... health literacy award winners. The IHA Health Literacy Awards ... an impact on the practice of educating or empowering ... IHA gives awards in three categories: innovative programs, published ... Health Literacy Hero award. In the area ...
Breaking Medicine Technology:United States ACO IT Spending Outlook 2014-2018 2Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 2Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 3Institute for Healthcare Advancement Announces 2015 Award Winners 2
... Awarepoint Corporation , the leading provider of ... today that it named Ralph Keiser as executive vice ... president of marketing and business development to accommodate explosive ... domestic and international RTLS markets. (Logo: ...
... NEPH) announced today financial results for the three months ended March ... Increased revenues of $164,000 or 32% in the first quarter ... Rights Offering and Private Placement resulting in gross proceeds of approximately ... represented a transition period for Nephros," said Dr. Paul Mieyal, acting ...
Cached Medicine Technology:Awarepoint Expands Senior Management Team 2Awarepoint Expands Senior Management Team 3Nephros Reports First Quarter 2011 Financial Results 2Nephros Reports First Quarter 2011 Financial Results 3Nephros Reports First Quarter 2011 Financial Results 4Nephros Reports First Quarter 2011 Financial Results 5
... instrument engineered to match the speed of ... system is based on heat transfer by ... tubes or thin walled micorcentrifuge tubes. Heating ... high velocity air results in nearly instantaneous ...
Contains: Card, cabling and instructions to remotely access a RoboCycler® instrument from a PC or Macintosh® computer...
... Biosystems has designed its 60-well, 0.5 mL ... PCR applications (both DNA and RNA). The ... Frame ensure oil-free operation in the 0.5 ... the 0.5 mL GeneAmp PCR System 9700 ...
... Mx3005P instrument and custom filter wheels ... filters. The standard filter set includes: ... ROX/Texas Red (585nm-610nm), Cy5 (635nm-665nm) and ... Mx3005P analysis software, Beacon Designer oligo ...
Medicine Products: