Navigation Links
In brief: New prognostic indicator for patients with IPF
Date:2/19/2009

There may be a new way to predict mortality in patients with idiopathic pulmonary fibrosis (IPF), a devastating disease that slowly petrifies the lungs. Most patients live only three years after diagnosis on average; however, some remain stable for many years, while for others, the disease progresses more rapidly.

"There is no effective treatment [for IPF] and many patients, if eligible, are referred for lung transplantation. Identification of surrogate short-term measures of mortality is critical to the management and study of patients with IPF." explained lead author Charlene Fell, M.D., of the Division of Respiratory Medicine at the University of Calgary.

The study found that maximal oxygen uptake during exercise, or VO2max, can predict mortality in IPF patients. VO2max is an integrated measure of cardiovascular, respiratory and neuromuscular function and is a standard measure during cardiopulmonary exercise testing.

The results were published in the first issue for March of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Dr. Fell and colleagues performed a retrospective analysis of 117 patients in the University of Michigan's Specialized Center of the Pathobiology of Fibrotic Lung Disease database and analyzed their oxygen uptake during exercise with their subsequent mortality.

"We found that VO2max examined as a continuous variable does not predict mortality in IPF. However, baseline threshold VO2max of 8.3 ml/kg/min predicts mortality in these patients," wrote Dr. Fell.

Those patients with a VO2max of less than 8.3 ml/kg/min had a risk of death more than three times that of patients whose VO2max was above the threshold. VO2max was compared with two other predictors of survival in IPF, oxygen desaturation during a six-minute walk test (6MWT) and resting arterial oxygen partial pressure (PaO2), and in both cases, VO2max was found to be a more robust predictor.

"Furthermore, VO2max is easier to use in the clinical setting than other predictors which require cumbersome calculations," said Dr. Fell.

"One caveat to the VO2max predictor is that only a small number of patients had a VO2max below the 8.3 ml/kg/min threshold in our study, [so] further prospective studies are needed to validate these findings," said Dr. Fell. "If the value of this predictor is proven in prospective studies, it may help clinicians prioritize patients for lung transplantation or identify patients for clinical trials."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. HPV18 DNA levels are not prognostic for precancerous cervical lesions
2. New prognostic markers for gastric cancer patients
3. Body Mass Index may serve as prognostic tool for advanced, aggressive breast cancers
4. Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
5. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
6. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
7. STERRAD(R) CYCLESURE(R) Biological Indicator is now 24 Hours, Accelerating Instrument Throughput
8. Stakeholders and public should use 20 specific health indicators
9. Stanford blood scanner detects even faint indicators of cancer
10. ED an Indicator of Mens Health
11. A new indicator for esophageal varix in alcoholic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... Amendia, Inc., designer, ... its strategic partnership with and platinum sponsorship of Global Spine Outreach (“GSO”), a ... effective management of complex spine deformity cases, particularly in children. , GSO’s focus ...
(Date:4/24/2017)... Lake City, UT (PRWEB) , ... April 24, 2017 , ... ... their efforts to encourage sustainability, innovate new strategies to reduce waste, and support renewable ... herbal remedy provider. They look to nature to find solutions for health issues, and ...
(Date:4/24/2017)... , ... April 24, 2017 , ... The California Dental ... in charitable dental services to 1,961 people during the April 22-23 event at the ... charge to Californians who experience barriers to care, CDA Cares educates the public and ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... seeking public support to bring their novel lifesaving device for the everyday use ... with medical-grade sensors, specially designed to read a child’s vital signs, and detect ...
(Date:4/24/2017)... CA (PRWEB) , ... April 24, 2017 , ... ... brain tumors are expected to be diagnosed globally; approximately 25,000 of them will ... are anticipating greater use of this type of healthcare model in the diagnosis ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  AbbVie (NYSE: ... 99 percent (n=145/146) of chronic hepatitis C virus ... 5 or 6 and compensated cirrhosis (Child-Pugh A) ... (SVR 12 ) with its investigational, pan-genotypic regimen ... rates were seen following 12 weeks of G/P ...
(Date:4/20/2017)... NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical results demonstrating anti-fibrotic effects with NV556, ... (NASH), in an additional well-validated experimental NASH ... previously shown similar anti-fibrotic effects in the ... present novel data demonstrating anti-fibrotic effects of ...
(Date:4/19/2017)... Cardiology devices segment is anticipated to reach the ... Cardiology Devices segment is likely to create absolute $ opportunity ... over 2017. By the end of 2027, Cardiology Devices segment ... 700 Mn, expanding at a CAGR of 18.4% over the ... Asia Pacific reprocessed medical devices market in terms ...
Breaking Medicine Technology: