Navigation Links
In brief: New prognostic indicator for patients with IPF
Date:2/19/2009

There may be a new way to predict mortality in patients with idiopathic pulmonary fibrosis (IPF), a devastating disease that slowly petrifies the lungs. Most patients live only three years after diagnosis on average; however, some remain stable for many years, while for others, the disease progresses more rapidly.

"There is no effective treatment [for IPF] and many patients, if eligible, are referred for lung transplantation. Identification of surrogate short-term measures of mortality is critical to the management and study of patients with IPF." explained lead author Charlene Fell, M.D., of the Division of Respiratory Medicine at the University of Calgary.

The study found that maximal oxygen uptake during exercise, or VO2max, can predict mortality in IPF patients. VO2max is an integrated measure of cardiovascular, respiratory and neuromuscular function and is a standard measure during cardiopulmonary exercise testing.

The results were published in the first issue for March of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Dr. Fell and colleagues performed a retrospective analysis of 117 patients in the University of Michigan's Specialized Center of the Pathobiology of Fibrotic Lung Disease database and analyzed their oxygen uptake during exercise with their subsequent mortality.

"We found that VO2max examined as a continuous variable does not predict mortality in IPF. However, baseline threshold VO2max of 8.3 ml/kg/min predicts mortality in these patients," wrote Dr. Fell.

Those patients with a VO2max of less than 8.3 ml/kg/min had a risk of death more than three times that of patients whose VO2max was above the threshold. VO2max was compared with two other predictors of survival in IPF, oxygen desaturation during a six-minute walk test (6MWT) and resting arterial oxygen partial pressure (PaO2), and in both cases, VO2max was found to be a more robust predictor.

"Furthermore, VO2max is easier to use in the clinical setting than other predictors which require cumbersome calculations," said Dr. Fell.

"One caveat to the VO2max predictor is that only a small number of patients had a VO2max below the 8.3 ml/kg/min threshold in our study, [so] further prospective studies are needed to validate these findings," said Dr. Fell. "If the value of this predictor is proven in prospective studies, it may help clinicians prioritize patients for lung transplantation or identify patients for clinical trials."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. HPV18 DNA levels are not prognostic for precancerous cervical lesions
2. New prognostic markers for gastric cancer patients
3. Body Mass Index may serve as prognostic tool for advanced, aggressive breast cancers
4. Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
5. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
6. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
7. STERRAD(R) CYCLESURE(R) Biological Indicator is now 24 Hours, Accelerating Instrument Throughput
8. Stakeholders and public should use 20 specific health indicators
9. Stanford blood scanner detects even faint indicators of cancer
10. ED an Indicator of Mens Health
11. A new indicator for esophageal varix in alcoholic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... Thomas Jefferson ... Witness , was awarded a $300,000 grant from The Pew Center for Arts ... with ambiguity and the recognition of one’s own limits among health professions students. ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... $5,000 grant from the C. R. Bard Foundation, Inc. to support ... Hills , a service available through the nonprofit home care agency. Using evidence-based ...
(Date:7/21/2017)... ... 21, 2017 , ... In the first prospective ACL reconstruction ... Outcome Network (MOON) demonstrated that patients could perform sports-related functions and maintain a ... over time. The study, presented today at the American Orthopaedic Society for ...
(Date:7/20/2017)... MA (PRWEB) , ... July 20, 2017 , ... ... form of blood and bone marrow cancer that progresses rapidly without treatment. Newly ... recommended to reduce the chance of reoccurrence and relapse. With such a ...
(Date:7/20/2017)... ATLANTA, Ga. (PRWEB) , ... July 20, 2017 , ... ... and equal access to medicine for everyone affected by diabetes, is teaming up with ... the five-day global event kicks off on July 24th. , “Team Type 1’s ...
Breaking Medicine News(10 mins):
(Date:7/19/2017)...  Mako Medical Laboratories partnered with Secretary Strickland, the ... Fund (MFA) to bring 140 soldiers back home to ... families one last time before being deployed. Mako Medical ... logistics needed for these soldiers. "Mako Medical Laboratories is ... We just wish we could bring them all home," ...
(Date:7/13/2017)...  Centurion Medical Products, a leader in medical product innovation and ... removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part of a ... pain while preventing unneeded emergency department admission due to severe fecal ...
(Date:7/11/2017)... , July 11, 2017 Zymo Research Corp., also known ... that can quantify biological aging in a precise manner using the myDNAge ... Steve Horvath , a professor of human genetics and biostatistics at the ... School of Public Health , Zymo Research,s proprietary DNAge ™ technology ... ...
Breaking Medicine Technology: