Navigation Links
In blood vessel stents, innovative materials allow better control, delivery of gene therapy
Date:4/15/2008

Before gene therapy becomes practical for treating human diseases, researchers must master the details of safe and effective delivery. Cardiology researchers at The Childrens Hospital of Philadelphia have advanced delivery techniques by creating a versatile synthetic material that can bind to a variety of gene therapy vectors and can be custom-designed for controlled local release of therapeutic genes at a disease site.

In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an enzyme that significantly reduced restenosis, the hazardous narrowing of a blood vessel that often occurs despite the presence of a stent designed to hold it open.

Although the materials are in an early stage, the hope is that this method may help to treat artery disease in people. We developed a synthetic gene delivery system that can be used for any gene therapy vector, not just adenoviruses, said study leader Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Childrens Hospital of Philadelphia. Furthermore, this new formulation allows us to increase the dosage of gene therapy vectors delivered, and we can tune the materials for sustained release over a longer time period.

Levys group reported its study this week in the online version of the journal Circulation, published by the American Heart Association.

Over the past decade, stents have become increasingly useful in treating constricted blood vessels in heart disease and in peripheral artery disease. Stents, which expand partially blocked blood vessels to improve circulation, may be made of bare metal or may have a coating of polymers that release drugs.

Neither type is ideal. Polymer coatings cause inflammation in vessels, which may lead to new bottlenecks at the same time th
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Mediware Introduces Comprehensive Vision for Blood Center Technology
2. High Blood Pressure May Be Buffer Against Headaches
3. Potential blood test for chronic sinusitis identified
4. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
5. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
6. PATHFAST(R): Rapid Whole Blood Immunoassay Analyzer from Polymedco
7. Blood vessels: The pied piper for growing nerve cells
8. Cholesterol, blood pressure control may reverse atherosclerosis in adults with diabetes
9. Aggressive Cholesterol, Blood Pressure Treatment Shows Some Benefit
10. Microwave treatments for enlarged prostate cause blood pressure surges
11. Blood pressure enzyme can have tumor-sensing role
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2009)...iminate triggers, experts advise , , SAT...oges, but people with allergies and asthma can hav...need to take special steps to prevent sneezing and...lergy, Asthma and Immunology (ACAAI). , Those w...ecorate with artificial plants, but both live and ...
(Date:12/5/2009)... Wind Turbines are popping up in the most... mushrooms, making wine to keeping prisoners in ja... 2009 -- Who would have thought that your wine, wa...nes? Wind Inc. of Fort Worth, Texas has announced ...t wind farms. "Using a technology developed to pr...
(Date:12/4/2009)... PEMBROKE, Bermuda, Dec. 4 /PRNewswire-FirstCall/...NYSE: AWH ) today announced that Scott Carmilani...Sennott, Executive Vice,President and Chief Corpor...09,Goldman Sachs U.S. Financial Services Conferenc...r in New York City on Tuesday, December 8, 2009. ,...
(Date:12/4/2009)...AHEIM, Calif., Dec. 4 Pamela Bowen..., was selected as a finalist for the "Chief Innova...,s business with the power of cloud computing. App...novative usage of Salesforce CRM or the Force.com ...s to their sales, marketing, partner, service, sup...
(Date:12/4/2009)... mice, scientists at Johns Hopkins publishing in t... protein made by a gene called "Twist" may be the ...h stem cells that drive aggressive, metastatic bre...lding on recent work suggesting that it is a relat... that drives breast cancer, scientists have surmis...
Breaking Medicine News(10 mins):Health News:Keep Asthma, Allergies at Bay for the Holidays 2Health News:Distributor Announces New Applications for Wind Turbines 2Health News:Distributor Announces New Applications for Wind Turbines 3Health News:Allied World to Present at the 2009 Goldman Sachs U.S. Financial Services Conference 2Health News:Crescent CIO '09 Dreamforce Conference Speaker and Award Finalist 2Health News:Potential new 'twist' in breast cancer detection 2Health News:Potential new 'twist' in breast cancer detection 3
... to a new study, at the University of Texas, menta...for suicide in young people. This despite earlier ...a major role. Researchers in Denmark set out ...icide that took place from 1980 to 1995 in people ...
... to researchers, doctors should begin evaluating p...blood pressure and cholesterol levels, beginning a...ed Monday in new guidelines for the prevention of ... an opportunity to make large changes in behavior ...
... to researchers, women who have had a complicated ...diabetes and heart disease later on. Researchers i...justifies monitoring women who have had difficult ...sk of mid-life diabetes. Similarly, those who have...
...th heart valve problems are generally advised to t...he risk of serious infection. But many who need th...doctors never offer advice about them and may not ...crease compliance with the antibiotic recommendati...
...hotographs could help detect people who are at hig...They say their technique is cheap enough to be use...okes are caused by brain cell death due to bleedin...e with changes to their network of blood vessels -...
... to researchers, American women who are health hav...erol. Much of the research on risk factors for hea... doctors at Columbia University report on how chol... aged from 30 to 95 years. The women were followed...
Other Medicine News:Health News:Heart attack risk starts at 20 2
(Date:12/4/2009)..., , TARRYTOWN, N.Y., Dec. 4 /PRNewswir...e grand prize winners of Bayer,s "Express Your Sim...nas Brothers, selected the winning video entries s... country. The grand prize is an in-person meeting ...e 1 diabetes like Nick, are: Caleb, age 6, from Da...
(Date:12/4/2009)..., , WILMINGTON, Del., Dec. 4 /PRNewswire-...ounced that the US Food and Drug Administration (F...tiapine fumarate) Extended Release Tablets as adju...ults with Major Depressive Disorder (MDD). SEROQUE...by the FDA to treat both major depressive disorder...
(Date:12/3/2009)..., , ACTON, Mass., Dec. 3 /PRNewswire-Fir...Hill-Rom Holdings, Inc. (NYSE: HRC ), today anno...(Original Equipment Manufacturer) business website...forces the Allen Amatech(TM) brand identity and in...g, with detailed descriptions and design specifica...
Breaking Medicine Technology:Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 2Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 3US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 2US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 3US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 4US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 5US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 6US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 7US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 8US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 9Allen Medical Systems Announces the Launch of New Allen Amatech(TM) OEM Website 2New study ushers in spring time for slow inactivation 10771 1A second skin 10768 1Driven by Customer Feedback BodyMedia Inc Announces Major Enhancements and Brand Change for GoWear Fit 61535 1Driven by Customer Feedback BodyMedia Inc Announces Major Enhancements and Brand Change for GoWear Fit 61535 2Driven by Customer Feedback BodyMedia Inc Announces Major Enhancements and Brand Change for GoWear Fit 61535 3Driven by Customer Feedback BodyMedia Inc Announces Major Enhancements and Brand Change for GoWear Fit 61535 4
...FROM PHASE 3 CLINICAL TRIAL FOR NATURLOSE(R) ANTIC...ix Incorporated (Nasdaq: SPEX ), an innovator in...ulatory consulting services to food, supplement, b...nnounced the postponement of its 2009 Annual Share...e meeting will instead be held during the Fall of ...
...ipants Sought For Landmark Study To Measure Effect...Ohio, March 11 Lake Hospital System today announc...ulas Foundation to support a groundbreaking study ...health-related outcomes for patients with diabetes...ticipants for the three-year music therapy study, ...
Other Medicine Technology:Spherix Postpones 2009 Annual Shareholders Meeting to Share Interim Diabetes Clinical Trial Data 2Spherix Postpones 2009 Annual Shareholders Meeting to Share Interim Diabetes Clinical Trial Data 3Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study 2Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study 3Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study 4
MRI Compatible Syringe Pump
Victory® DR Model 5810
Infinix CF-i/BP
...fying patients and visitors is crucial for creatin...ieve this and more with the Dynamic Hospital Ident...ification system, fit for hospitals of any size. I...s a fully-integrated component of existing enterpr...
Medicine Products: