Navigation Links
In animal study, 'cold turkey' withdrawal from drugs triggers mental decline
Date:11/8/2013

SAN DIEGO Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Georgetown University Medical Center researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people.

"Over time, drug-abusing individuals often develop mental disorders," says Italo Mocchetti, PhD, a professor of neuroscience. "It's been thought that drug abuse itself contributes to mental decline, but our findings suggest that 'quitting cold turkey' can also lead to damage."

In the study published in the November issue of Brain, Behavior and Immunity and presented at Neuroscience 2013, Mocchetti and his research colleagues treated the animals with morphine, or allowed them to undergo withdrawal by stopping the treatment. Then, they measured pro-inflammatory cytokines, which can promote damage and cell death, and the protein CCL5, which has various protective effects in the brain.

"Interestingly, we found that treating the addicted animals with morphine both increased the protective CCL5 protein while decreasing pro-inflammatory cytokines, suggesting a beneficial effect," Mocchetti explains. The animals that weren't treated during withdrawal had the opposite results decreased CCL5 and increased levels of the damaging cytokines.

"From these findings, it appears that morphine withdrawal may be a causative factor that leads to mental decline, presenting an important avenue for research in how we can better help people who are trying to quit using drugs," concludes Mocchetti.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers develop a new cell and animal model of inflammatory breast cancer
2. FDA Seeks to Limit Antibiotics in Animal Feed
3. Animals More Interesting to Kids Than Toys, Study Shows
4. Raucous Music May Tap Into Your Inner Animal
5. Recruiting for Good Launches Pet Philanthropy Program to Collaboratively Fundraise for Kitt Crusaders an Animal Rescue Organization
6. Woodbridge Animal Hospital Unleashes New Pet Care Website
7. Chicago Dog Bite Injury Lawyers Advise Dog Owners To Get Control of Their Animals, Or Be Prepared To Pay Up
8. New technique could reduce number of animals needed to test chemical safety
9. Potential treatment target identified in an animal model of pancreatic cancer
10. New animal model may lead to treatments for common liver disease
11. Lab-engineered muscle implants restore function in animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... 03, 2015 Indiana Fiber Network, LLC ... Bank Computer Services, Inc (BCS) has selected IFN as ... states, “The technology, service, and working relationship with IFN ... the local feel you get with IFN. I ... IFN makes local decisions and operates as a local ...
(Date:5/3/2015)... May 03, 2015 Looking for ... will directly impact your career? The Master of ... dynamic leaders in multinational companies and for professionals ... a changing global landscape, differences in culture, religion, ... The EMIB program develops the global competence and ...
(Date:5/3/2015)... SpineFrontier, a Less Exposure Surgery (LES) ... produce and market their new sacroiliac joint fusion screw, ... outpatient settings and is compatible with both lateral and ... been extensively researched and refined by SpineFrontier, the first ... approach in conjunction with a sacroiliac joint fusion system ...
(Date:5/3/2015)... Burnsville MN (PRWEB) May 03, 2015 ... in workplace safety solutions, announces its appearance at the ... Health Conference. Products that HealthPostures will exhibit at the ... Largest of the sit stand solutions is the 6100 ... push button height control, an adjustable keyboard tray, extended ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 Ticket Down has ... for the long awaited event today, Saturday, May 2nd ... Diehard boxing fans will be able to secure tickets for ... The fight that boxing fans have wanted for more than ... ago. Floyd “Money” Mayweather will step inside the ring to ...
Breaking Medicine News(10 mins):Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 3Health News:The Saint Louis University's Master of International Business Is Now Enrolling For Fall 2015 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 3Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3
Shiv Sena on Sunday strongly reacted to the recent Union Health Ministry notice to yoga guru Baba Ramdev,// saying the government is compromising national interests in connivance with multinational co...
... Atlas released early December in South Africa confirms that ... India in the pre-diabetic phase (Impaired Glucose Tolerance, IGT). ... that began in 2000, begins with the preamble: "With ... increasing rate, the prevalence of diabetes is predicted to ...
... from the Institute Pasteur has recently shown that the ... host's fat cells. //This formidable pathogen is protected against ... which it may remain dormant for years. ... on possible strategies for fighting tuberculosis. Attempts to eradicate ...
... An enzyme found at elevated levels in several human ... fruit flies//, a discovery that provides a new model ... cancer, according to researchers. ,Using fluorescent staining and ... in a gene called aurora-A to observe how changes ...
... collaborators have found that the genetically engineered bacteria that ... set the stage for a new, biobased method of ... toothpaste, mouthwash and other products. ,Xylitol is ... to some degree by the human body. It is ...
... the Department of Health plans, school girls as young ... disease, which can cause cervical cancer//. Researchers have found ... the key causes of cervical cancer, which kills around ... be immunized against the human papilloma virus (HPV) before ...
Cached Medicine News:Health News:Tuberculosis: The Bacillus Takes Refuge in Adipose Cells 2Health News:Run Amok Enzyme Causes Same Problems in Both Humans and Fruit Flies 2
(Date:5/1/2015)... May 1, 2015  Thoratec Corporation (NASDAQ: THOR ), ... support and restore failing hearts, announced today that Marta ... of President, International. This new Europe ... outside of North America , including ... Latin America , and reports directly to ...
(Date:5/1/2015)... 1, 2015 Braeburn Pharmaceuticals announced ... therapeutic focus beyond addiction and pain to ... Braeburn has acquired an implantable, six-month formulation ... for treatment of schizophrenia from Endo Pharmaceuticals. ... rights to other potential applications of the ...
(Date:5/1/2015)... SUNNYVALE, Calif., May 1, 2015 Pharmacyclics, Inc. ... results for the quarter ended March 31, 2015, as ... merger with AbbVie Inc., no conference call will be held. ... the quarter ended March 31, 2015 increased to $206 ... 31, 2014. , Worldwide IMBRUVICA ® (ibrutinib) ...
Breaking Medicine Technology:Thoratec Announces Addition To Senior Management Team 2Thoratec Announces Addition To Senior Management Team 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 2Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 4Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 2Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 3Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 4Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 5Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 6Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 7Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 8Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 9Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 10Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 11Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 12Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 13Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 14Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 15Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 16Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 17Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 18Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 19Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 20Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 21Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 22Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 23Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 24Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 25Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 26Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 27Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 28Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 29Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 30Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 31
... Following is a statement by Linda A. Suydam, D.P.A., president ... of the National Institute on Drug Abuse,s (NIDA,s) Monitoring the ... the Future survey speak to the need for continued efforts ... to talk to their teens about medicine abuse. The Consumer ...
... , DUBLIN, Ohio, Dec. 14 Cardinal Health ... the following events: , Goldman Sachs CEO Unplugged Conference ... Conference Center in New York. 28th Annual J.P. Morgan ... Westin St. Francis Hotel in San Francisco. , At these ...
Cached Medicine Technology:Statement From the Consumer Healthcare Products Association(CHPA) on Annual Monitoring the Future Survey on Drug Abuse 2Statement From the Consumer Healthcare Products Association(CHPA) on Annual Monitoring the Future Survey on Drug Abuse 3Cardinal Health Executives to Speak at Two Investor Events in January 2
The opaque outer circle will white-out even the darkest iris, making your pupil the only spot of black in a sea of white....
This lens gives the appearance of mystery and mayhem behind the blackest of eyes....
Soft silicone brush tip allows atraumatic brushing and manipulation of retina surface. Silicone brush extends 3mm beyond end of cannula. Luer lock hub for easy, secure connection to a backflush handl...
Healon vitreous aspirating cannula, 21 gauge....
Medicine Products: