Navigation Links
In NIH-funded study, researchers uncover step in brain events leading up to addiction
Date:8/15/2010

A regulatory protein best known for its role in a rare genetic brain disorder also may play a critical role in cocaine addiction, according to a recent study in rats, funded by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health. The study was published today in the journal Nature Neuroscience.

Researchers at the Scripps Research Institute in Jupiter, Fla. found that cocaine consumption increased levels of a regulatory protein called MeCP2 that shuttles back to the nucleus to influence gene expression in the brains of rats. As levels of MeCP2 increased in the brain, so did the animals' motivation to self-administer cocaine. This suggests that MeCP2 plays a crucial role in regulating cocaine intake in rats and perhaps in determining vulnerability to addiction.

"This discovery, using an animal model of addiction, has exposed an important effect of cocaine at the molecular level that could prove key to understanding compulsive drug taking," said Dr. Nora D. Volkow, director of NIDA. "It should open up new avenues of research on the causes and ways to counter the behavioral changes linked to addiction in humans."

This is the second time this year that a critical factor related to cocaine self-administration in rodents has been identified. In a study published in July in the journal Nature, Scripps researchers identified regulatory molecule miRNA-212 as playing a key role in cocaine intake. However, MeCP2 increased motivation for cocaine, whereas miRNA-212 had the opposite effect, suggesting that the latter plays a protective role against drug seeking.

In the current study, researchers discovered that the brain's balance between MeCP2 and miRNA-212 ultimately regulates cocaine intake. When the balance shifts toward MeCP2, cocaine intake increases. When the balance shifts toward miRNA-212, cocaine intake decreases. What determines the balance is not yet understood, however, and will be the focus of future research.

"This study represents another piece in the puzzle of determining vulnerability to cocaine addiction," said Paul J. Kenny, senior author on the study and an associate professor at Scripps. "If we can continue putting the pieces together, we may be able to determine whether there are viable treatments for this condition."


'/>"/>

Contact: NIDA Press Office
media@nida.nih.gov
NIH/National Institute on Drug Abuse
Source:Eurekalert

Related medicine news :

1. NIH-funded study finds early HAART during TB treatment boosts survival rate in co-infected people
2. University of Mississippi Medical Center to lead in nationwide NIH-funded Alzheimers study
3. NIH-funded scientists find 2009 H1N1 pandemic influenza vaccine protects mice from 1918 flu virus
4. Researchers develop magnetic molecular machines to deliver drugs to unhealthy cells
5. UCLA researchers discover protein that shuttles RNA into cell mitochondria
6. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
7. NIST researchers measure high infrared power levels from some green lasers
8. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
9. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
10. Researchers identify key enzyme in DNA repair pathway
11. Researchers study benefits of white button mushrooms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... extensive sequencing and genomics experience, as Vice President of North American Capital Sales at ... responsible for leading the sales team in the commercialization of the HTG EdgeSeq system ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: