Navigation Links
In Mice, Drug Reverses Symptoms of Condition Linked to Autism
Date:4/11/2012

WEDNESDAY, April 11 (HealthDay News) -- An experimental drug reversed many of the major symptoms of Fragile X syndrome in mice, researchers report.

Fragile X syndrome is a leading cause of autism, and its symptoms include developmental delays, hyperactivity, learning and memory difficulties, low IQ, seizures and social and communication deficits.

Prior research suggested that inhibiting mGlu5, a receptor for a neurotransmitter known as glutamate, might help alleviate some symptoms.

In the new study, researchers in Switzerland and at the Massachusetts Institute of Technology treated adult mice genetically engineered to have Fragile X syndrome with a compound called CTEP, which inhibits mGlu5.

"We found that even when treatment with CTEP was started in adult mice, it reduced a wide range of [Fragile X] symptoms," study author Dr. Lothar Lindemann, of F. Hoffmann-La Roche Ltd. in Basel, said in a journal news release.

Symptoms that showed improvement included learning and memory challenges and hypersensitivity to sounds.

Although studies involving animals can be useful, they frequently fail to produce similar results in humans, experts noted. The study's authors also pointed out that CTEP was not developed for use in people. The findings, however, could help scientists pursue a similar treatment for people with Fragile X.

"The most important implications of our study are that many aspects of [Fragile X] are not caused by an irreversible disruption of brain development, and that correction of the altered glutamate signaling can provide widespread therapeutic benefit," said Mark Bear, of MIT's Picower Institute for Learning and Memory.

The study is published in the April 12 issue of the journal Neuron.

More information

The U.S. National Institutes of Health provides more information on Fragile X syndrome.

-- Mary Elizabeth Dallas

SOURCE: Cell Press, news release, April 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
2. Freezing breast tumors helps stop cancer’s spread in mice, U-M study finds
3. Cleveland Clinic study shows bariatric surgery improves, reverses diabetes
4. Drug reverses aging-associated changes in brain cells
5. Leukemia drug reverses tamoxifen-resistance in breast cancer cells
6. Surgery-related weight loss in men reverses testosterone deficiency
7. Breakthrough medical food reverses risk of heart disease and diabetes
8. Heart damage improves, reverses after stem cell injections in a preliminary human trial
9. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
10. Vaccine Reverses Type 1 Diabetes in Mice
11. Childhood traumatic experiences associated with adult IBS symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... PrideStaff, a national, franchised staffing organization ... Turner Pizarro, was recently featured on Fox Business Network's Worldwide Business with kathy ... leaders from across the globe, provides viewers an opportunity to find solutions to ...
(Date:1/18/2017)... ... January 18, 2017 , ... Dr. Farhan Qureshi is an esteemed dentist who ... modern dental practice has two convenient office locations in Alexandria and Arlington, Virginia. Recently, ... for the Alexandria area. This award confirms the fact that Dr. Qureshi’s patients ...
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, ... Brake Technology (ABT), an innovative braking system that allows skaters of all levels ... one of the biggest concerns of beginner and intermediate skaters – learning how ...
(Date:1/17/2017)... ... ... Anesthesia Progress – Everyone wants less pain during dental surgery, but it can ... have several general anesthesia alternatives and finding the right option can result in less ... Tokyo, Japan wanted to find out which anesthetic was the better choice in a ...
(Date:1/17/2017)... ... January 17, 2017 , ... Today, to help those who ... powerfully uplifting interview with medical expert and prolific author, Dr. Bernie Siegel. ... tough times, Dr. Bernie Siegel energizes listeners to live life with intrigue, magic ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)...  Robust competition in the private marketplace is resulting in ... to a new study by the Berkeley ... to examine the share of prescription medicine spending retained ... health plans and other stakeholders in the supply chain. ... show what happens when the list price of a ...
(Date:1/17/2017)... North America Insulin Delivery Market Outlook to ... Insulin Delivery Market Outlook to 2022", provides key market ... report provides value, in millions of US dollars, volume ... - Insulin Pens, Insulin Pumps, Insulin Syringes and Traditional ... shares and distribution shares data for each of these ...
(Date:1/17/2017)... , Jan 17, 2017 Research and ... Healing Materials: 2017 - 2024" report to their offering. ... This new report ... market report that was issued in May of 2015. Self-healing is ... In our previous analysis we projected a market potential of $2.7 ...
Breaking Medicine Technology: