Navigation Links
In Mice, Drug Reverses Symptoms of Condition Linked to Autism
Date:4/11/2012

WEDNESDAY, April 11 (HealthDay News) -- An experimental drug reversed many of the major symptoms of Fragile X syndrome in mice, researchers report.

Fragile X syndrome is a leading cause of autism, and its symptoms include developmental delays, hyperactivity, learning and memory difficulties, low IQ, seizures and social and communication deficits.

Prior research suggested that inhibiting mGlu5, a receptor for a neurotransmitter known as glutamate, might help alleviate some symptoms.

In the new study, researchers in Switzerland and at the Massachusetts Institute of Technology treated adult mice genetically engineered to have Fragile X syndrome with a compound called CTEP, which inhibits mGlu5.

"We found that even when treatment with CTEP was started in adult mice, it reduced a wide range of [Fragile X] symptoms," study author Dr. Lothar Lindemann, of F. Hoffmann-La Roche Ltd. in Basel, said in a journal news release.

Symptoms that showed improvement included learning and memory challenges and hypersensitivity to sounds.

Although studies involving animals can be useful, they frequently fail to produce similar results in humans, experts noted. The study's authors also pointed out that CTEP was not developed for use in people. The findings, however, could help scientists pursue a similar treatment for people with Fragile X.

"The most important implications of our study are that many aspects of [Fragile X] are not caused by an irreversible disruption of brain development, and that correction of the altered glutamate signaling can provide widespread therapeutic benefit," said Mark Bear, of MIT's Picower Institute for Learning and Memory.

The study is published in the April 12 issue of the journal Neuron.

More information

The U.S. National Institutes of Health provides more information on Fragile X syndrome.

-- Mary Elizabeth Dallas

SOURCE: Cell Press, news release, April 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
2. Freezing breast tumors helps stop cancer’s spread in mice, U-M study finds
3. Cleveland Clinic study shows bariatric surgery improves, reverses diabetes
4. Drug reverses aging-associated changes in brain cells
5. Leukemia drug reverses tamoxifen-resistance in breast cancer cells
6. Surgery-related weight loss in men reverses testosterone deficiency
7. Breakthrough medical food reverses risk of heart disease and diabetes
8. Heart damage improves, reverses after stem cell injections in a preliminary human trial
9. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
10. Vaccine Reverses Type 1 Diabetes in Mice
11. Childhood traumatic experiences associated with adult IBS symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
Breaking Medicine Technology: