Navigation Links
In Mice, Drug Reverses Symptoms of Condition Linked to Autism
Date:4/11/2012

WEDNESDAY, April 11 (HealthDay News) -- An experimental drug reversed many of the major symptoms of Fragile X syndrome in mice, researchers report.

Fragile X syndrome is a leading cause of autism, and its symptoms include developmental delays, hyperactivity, learning and memory difficulties, low IQ, seizures and social and communication deficits.

Prior research suggested that inhibiting mGlu5, a receptor for a neurotransmitter known as glutamate, might help alleviate some symptoms.

In the new study, researchers in Switzerland and at the Massachusetts Institute of Technology treated adult mice genetically engineered to have Fragile X syndrome with a compound called CTEP, which inhibits mGlu5.

"We found that even when treatment with CTEP was started in adult mice, it reduced a wide range of [Fragile X] symptoms," study author Dr. Lothar Lindemann, of F. Hoffmann-La Roche Ltd. in Basel, said in a journal news release.

Symptoms that showed improvement included learning and memory challenges and hypersensitivity to sounds.

Although studies involving animals can be useful, they frequently fail to produce similar results in humans, experts noted. The study's authors also pointed out that CTEP was not developed for use in people. The findings, however, could help scientists pursue a similar treatment for people with Fragile X.

"The most important implications of our study are that many aspects of [Fragile X] are not caused by an irreversible disruption of brain development, and that correction of the altered glutamate signaling can provide widespread therapeutic benefit," said Mark Bear, of MIT's Picower Institute for Learning and Memory.

The study is published in the April 12 issue of the journal Neuron.

More information

The U.S. National Institutes of Health provides more information on Fragile X syndrome.

-- Mary Elizabeth Dallas

SOURCE: Cell Press, news release, April 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
2. Freezing breast tumors helps stop cancer’s spread in mice, U-M study finds
3. Cleveland Clinic study shows bariatric surgery improves, reverses diabetes
4. Drug reverses aging-associated changes in brain cells
5. Leukemia drug reverses tamoxifen-resistance in breast cancer cells
6. Surgery-related weight loss in men reverses testosterone deficiency
7. Breakthrough medical food reverses risk of heart disease and diabetes
8. Heart damage improves, reverses after stem cell injections in a preliminary human trial
9. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
10. Vaccine Reverses Type 1 Diabetes in Mice
11. Childhood traumatic experiences associated with adult IBS symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
(Date:6/24/2016)... ... 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... service members that have been wounded in battle and their families. Venture Construction Group ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: