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In Combination With FOLFOX4, the Effect of Erbitux and Avastin On Survival Rates Will Drive Prescription Decisions in the Treatment of Stage III Colon Cancer
Date:2/20/2008

Following its Approval, Erbitux Will Earn Gold-Standard Status in 2011,

According to a New Report from Decision Resources

WALTHAM, Mass., Feb. 20 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that a drug's effect on overall survival is the attribute that most influences oncologists' prescribing decisions in the treatment of stage III colon cancer. Clinical data and expert opinion shows that Bristol-Myers Squibb/ImClone Systems/Merck KGaA's Erbitux and Roche/Genentech/Chugai's Avastin have advantages in this attribute when used in combination with sales-leading FOLFOX4 treatment. FOLFOX4 is comprised of oxaliplatin (Sanofi-Aventis's Eloxatin/Eloxatine, Yakult's Elplat), 5- fluorouracil and leucovorin.

The new report entitled Colon Cancer (Stage III): Therapies Must Increase Survival over FOLFOX to Reach Blockbuster Status finds that surveyed oncologists indicate that a therapy which improves disease-free survival over FOLFOX4 at three years would earn a 60% patient share and achieve blockbuster status. The report forecasts that Avastin, in combination with FOLFOX4, will earn a 22% patient share in the U.S. stage III colon cancer market in 2016. Additionally, owing to its efficacy, safety and tolerability, Erbitux in combination with FOLFOX4 will earn gold-standard status for stage III colon cancer in 2011, following its approval for the indication in 2010 in the U.S. and Europe.

"When using both drugs in combination with FOLFOX4, experts gave Erbitux a slightly higher score over Avastin in safety and tolerability," said Marcus Hoyle, analyst at Decision Resources. "Oncologists indicated that the cardiovascular toxicity associated with VEGF inhibitors, such as Avastin, has a more negative impact on their prescribing decisions than the tissue disorders associated with EGFR inhibitors, such as Erbitux."

About the Report '/>"/>

SOURCE Decision Resources, Inc.
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