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Improving understanding of cell behavior in breast cancer
Date:6/18/2008

ngham team has shown using tumour sections from 177 patients that 96 per cent of vascular invasion in primary invasive breast cancer is predominantly of the lymph vessels. This is significant.

It is important that this finding is verified in a larger cohort of patients. The researchers are now working to accomplish this, through funding recently obtained from Cancer Research UK, using specimens from more than a thousand women with early stage breast cancer. Results from this study will also allow them to determine whether Lymphatic Vascular Invasion can be incorporated into an improved prognostic index for early stage breast cancer.

This work is being combined with gene expression studies, with bioinformatic approaches and using in vitro (cells in culture) models to identify novel therapeutic targets. It is being conducted in collaboration with a number of groups, industrial and academic, from both the UK and overseas.


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Contact: Ian Ellis
ian.ellis@nottingham.ac.uk
44-011-596-91169
University of Nottingham
Source:Eurekalert

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