Navigation Links
Improving chemotherapy effectiveness by acting on the immune system
Date:12/4/2012

This press release is available in French.

These results reveal how the immune system can then limit the effectiveness of some cancer chemotherapies. The researchers now intend to block the molecules responsible for negative immune system activation to increase the efficiency of chemotherapy. A clinical trial to test this hypothesis should begin very soon.

Chemotherapy is one of the most frequently used treatments to eliminate cancerous cells. These drugs kill all cells that are multiplying, or block their proliferation (for example, cells responsible for hair growth, explaining the hair loss of treated patients). In addition to their direct toxic effects, the chemotherapeutic agents also seem to act on the immune system and could make it possible for the body to trigger a direct antitumor immune response in a second phase. However, this last point is still the subject of hot debate, since some studies suggest, conversely, that chemotherapy eliminates all immune defences.

What now?

The Inserm team directed by Professor Franois Ghiringhelli (Inserm unit 866 "Lipids, nutrition and cancer") from the Georges Franois Leclerc Cancer Research Centre in Dijon observed that two chemotherapeutic agents, 5-fluorouracile and gemcitabine, used to treat colon, breast and pancreas cancers activate a protein complex "inflammasome NLRP3" within some cells in the immune system.

To be more specific, this activation leads to releasing proinflammatory cytokine (interleukin IL-1beta) through these cells. This cytokine "distorts" the immune response related to lymphocytes T and causes the production of another cytokine (cytokine IL-17), which has protumoral properties by encouraging tumour angiogenesis, i.e. vascular irrigation of tumours.

"Our results have made it possible to ascertain that the activation of inflammasome limits the eff
'/>"/>

Contact: Inserm press office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Callahan honored for improving older adults health in their doctors offices
2. Air Quality Improving in Many U.S. Cities: Report
3. Cedars-Sinai stroke team earns award for improving regions quality of care
4. Physician-Patient Alliance for Health & Safety: The Path to a Safer PCA Pump - Improving Patient Safety with Integrated Capnography
5. Supporting patient autonomy is critical to improving health
6. Improving the oral health of adults with special needs proves challenging
7. Disability caused by traumatic brain injury in children may persist and stop improving after 2 years
8. Improving quality of life for the bedridden
9. Research from ASCOS Quality Care Symposium shows advances and challenges in improving the quality of cancer care
10. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
11. U.S. Quit-Smoking Policies Need Improving, Experts Say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 23, 2014 Marietta, Georgia and surrounding ... homes. In an efforts to lower population of needy ... from the Tigg Neuter Project have joined forces. Local ... All proceeds will be presented to the Tigg Neuter ... animal clinic family are excited to attend and host the ...
(Date:7/22/2014)... DocbookMD , a HIPAA-secure mobile communication company, ... largest physician-centric mobile communication solutions in Texas at Memorial ... Created by Austin-based physicians, Tracey Haas, D.O., MPH, and ... into MHMD’s Accountable Care Network to enhance communication between ... put this capability at the fingertips of our physicians ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Obtaining a ... for military veterans who have hands-on medical experience. The ... at Greensboro today announced the launch of an accelerated ... experience. , The new program, the UNCG Veterans Access ... of approximately 24 veterans. With some prior college credit, ...
(Date:7/22/2014)... Air Conditioning & Heating Inc. is ... Daikin comfort pro dealer. This means that the company ... cooling system equipment. Only a select few businesses have ... being approved. , Daikin co-developed an R-410A refrigerant with ... Air Conditioning Market. They are also the inventor of ...
(Date:7/22/2014)... 2014 Dr. Jeremy K. Ueno, of ... have recently discussed the reasons for an increase in ... periodontics profession are seeing the amount of referrals they ... fact, one surgeon reported that over 50% of his ... implants have a very high success rate of up ...
Breaking Medicine News(10 mins):Health News:Marietta Vet Clinic Hosts 2014 Dog Days of Summer Pet Rescue Event 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 4Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2Health News:Air Conditioning & Heating Inc. Now an Authorized Daikin Comfort Pro Dealer 2Health News:Dr. Jeremy Ueno Can Help Treat Patients That Have Failing Implants 2Health News:Dr. Jeremy Ueno Can Help Treat Patients That Have Failing Implants 3
... 2007 As schools reopen around the country, a new study ... prevention starting as early as fourth grade. ,A review of ... shows that among typical 4th graders, 10% have already had ... a drink in the past year. While the numbers are ...
... is a,memorandum to editorial writers and columnists:, ... SUBJECT: Katrina Storm Warning, On the ... Orleans,and the Gulf Coast are struggling to rebuild ... in U.S. history. Disaster often strikes suddenly,and with ...
... one-sport specialization are likely culprits behind the increase, , , ... start specializing in one sport early -- playing year-round, ... special training programs -- believing they,ll put themselves on ... a pro sports career. , But for too many ...
... The Mutter Museum will be taking its two Presidential ... the Arden Theater,s ASSASSINS on September 19., PHILADELPHIA, ... Arden Theater will display the actual remains of two,of ... opening,night of the Arden,s production of Assassins, Wednesday, September ...
... Barry Karlin,Chairman and CEO of CRC HEALTH GROUP, ... announced the acquisition of Bayside Marin,Recovery Center (684 ... Located in Marin County, California, Bayside Marin ... The facility has an exceptional,reputation and provides a ...
... 15, 2007, RICHMOND, Va., Aug. 30 While ... and tissue donation in,2006, strongly held myths regarding donation ... becoming organ and tissue donors. In,recognition of Hispanic Heritage ... the Hispanic community, long celebrated for its,zest for life, ...
Cached Medicine News:Health News:Underage drinking starts before adolescence 2Health News:Underage drinking starts before adolescence 3Health News:Campaign for America's Future Memorandum: Katrina Storm Warning 2Health News:Campaign for America's Future Memorandum: Katrina Storm Warning 3Health News:Campaign for America's Future Memorandum: Katrina Storm Warning 4Health News:Campaign for America's Future Memorandum: Katrina Storm Warning 5Health News:More Kids Are Suffering Sports Injuries 2Health News:More Kids Are Suffering Sports Injuries 3Health News:The Mutter Assassins Go to the Theater! 2Health News:The Mutter Assassins Go to the Theater! 3Health News:CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael 2Health News:Donate Life America Dispels Myths About Organ & Tissue Donation Among Hispanics During National Hispanic Heritage Month 2
(Date:7/22/2014)... FRANCISCO , July 22, 2014  Nektar Therapeutics (Nasdaq: ... the second quarter ended June 30, 2014 on Thursday, July ... Howard Robin , president and chief executive officer, will host ... p.m. Eastern Time (ET)/2:00 p.m. Pacific Time (PT). ... the conference call can be accessed through a link that ...
(Date:7/22/2014)... , July 22, 2014 The National Space ... the Center for Space Radiation Research (CSRR) under the ... is an Associate Professor of Pharmaceutical Sciences within the ... Pharmacy Division of Radiation Health. She is located in ... direct a team of investigators working across four U.S. ...
(Date:7/22/2014)... York , July 22, 2014 ... Transparency Market Research "Process Spectroscopy Market (Technology Types - Near ... spectroscopy) Market - Global Industry Analysis, Size, Share, Growth, Trends ... USD 714.5 million in 2012 and is expected to grow ... North America was the largest ...
Breaking Medicine Technology:Nektar to Announce Financial Results for the Second Quarter 2014 on Thursday, July 31, 2014, After Close of U.S.-Based Financial Markets 2Nektar to Announce Financial Results for the Second Quarter 2014 on Thursday, July 31, 2014, After Close of U.S.-Based Financial Markets 3Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 2Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 3Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 4
... ProUroCare Medical, Inc. (OTC Bulletin Board: PUMD, PUMDU and ... it will be attending the American Urological Association (AUA) 2010 ... 29 – June 1 . At the conference, ... presented to educate urologists about the concept and potential of ...
... Zargis Medical Corp., a majority-owned subsidiary of ... it launched the live-streaming version of its ZargisTelemed™ platform ... San Antonio, TX. The system allows healthcare ... located anywhere in the world through the Internet or ...
Cached Medicine Technology:ProUroCare to Showcase Investigational Portable Platform for Its Prostate Imaging Device at AUA 2010 2Zargis Launches Telemedicine System with Real-Time Transmission of Stethoscope Sounds 2Zargis Launches Telemedicine System with Real-Time Transmission of Stethoscope Sounds 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: