Navigation Links
Improving chemotherapy effectiveness by acting on the immune system
Date:12/4/2012

This press release is available in French.

These results reveal how the immune system can then limit the effectiveness of some cancer chemotherapies. The researchers now intend to block the molecules responsible for negative immune system activation to increase the efficiency of chemotherapy. A clinical trial to test this hypothesis should begin very soon.

Chemotherapy is one of the most frequently used treatments to eliminate cancerous cells. These drugs kill all cells that are multiplying, or block their proliferation (for example, cells responsible for hair growth, explaining the hair loss of treated patients). In addition to their direct toxic effects, the chemotherapeutic agents also seem to act on the immune system and could make it possible for the body to trigger a direct antitumor immune response in a second phase. However, this last point is still the subject of hot debate, since some studies suggest, conversely, that chemotherapy eliminates all immune defences.

What now?

The Inserm team directed by Professor Franois Ghiringhelli (Inserm unit 866 "Lipids, nutrition and cancer") from the Georges Franois Leclerc Cancer Research Centre in Dijon observed that two chemotherapeutic agents, 5-fluorouracile and gemcitabine, used to treat colon, breast and pancreas cancers activate a protein complex "inflammasome NLRP3" within some cells in the immune system.

To be more specific, this activation leads to releasing proinflammatory cytokine (interleukin IL-1beta) through these cells. This cytokine "distorts" the immune response related to lymphocytes T and causes the production of another cytokine (cytokine IL-17), which has protumoral properties by encouraging tumour angiogenesis, i.e. vascular irrigation of tumours.

"Our results have made it possible to ascertain that the activation of inflammasome limits the eff
'/>"/>

Contact: Inserm press office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Callahan honored for improving older adults health in their doctors offices
2. Air Quality Improving in Many U.S. Cities: Report
3. Cedars-Sinai stroke team earns award for improving regions quality of care
4. Physician-Patient Alliance for Health & Safety: The Path to a Safer PCA Pump - Improving Patient Safety with Integrated Capnography
5. Supporting patient autonomy is critical to improving health
6. Improving the oral health of adults with special needs proves challenging
7. Disability caused by traumatic brain injury in children may persist and stop improving after 2 years
8. Improving quality of life for the bedridden
9. Research from ASCOS Quality Care Symposium shows advances and challenges in improving the quality of cancer care
10. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
11. U.S. Quit-Smoking Policies Need Improving, Experts Say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 2014 According to the ... recently updated by Vkool.com, this is a ... range of simple and easy tips for ...     Increasing omega-3 fatty acids ... ,     Increasing fiber ,     Avoid ...
(Date:7/14/2014)... 14, 2014 Vaginal Mesh lawsuit ... seven different pelvic mesh manufacturers in the U.S. District ... Schulte LLC. The federal complaints are pending against pelvic ... American Medical Systems (MDL No. 2325), and C.R. Bard, ... are 58,262 Vaginal Mesh lawsuit claims pending, according to ...
(Date:7/14/2014)... July 14, 2014 Doctor Mike Hamilton ... launch of their new company website. The Inception website ... information on chiropractic marketing. It's also a place for ... has to offer. , When contacted at his office, ... version of our main website. Our site is obviously ...
(Date:7/14/2014)... Texas (PRWEB) July 14, 2014 ... forefront in complete spine care—from diagnosis to treatment and ... locations are either certified in or training for certification ... Theresa Adame, have recently completed the extensive program. , ... utilizing The McKenzie Method results in better outcomes for ...
(Date:7/14/2014)... Sacramento, CA (PRWEB) July 14, 2014 ... a new office in Sacramento. The announcement has been made ... the office. In addition, the announcement has been made in ... their dental services in the Sacramento area. , Crystal Dental ... procedures. Some of the services offered by Crystal Dental include ...
Breaking Medicine News(10 mins):Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 4Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 5Health News:Doctor Mike Hamilton From Inception Chiropractic Websites Announces the Launch of Their New Website 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 3Health News:Crystal Dental Announces the Opening of New Office Location in Sacramento 2
... May 29 The following is a,statement by Matthew ... World Health Organization,s World No Tobacco Day, to be ... toll of the global,tobacco epidemic and the urgent need ... and save lives., This year,s theme -- Tobacco-Free ...
... Area ... hospitals, PLANO, Texas, May ... in Chicago,Illinois, has extended its relationship with the global information,technology provider. Perot ... ago, and in that period of,time its team of revenue cycle professionals ...
... Alseres,Pharmaceuticals, Inc. (Nasdaq: ALSE ) today ... of Stockholders Thursday, June 12, 2008 at 1:00,p.m. ... Hale & Dorr, 60 State,Street, Boston, MA., ... Pharmaceuticals, Inc., Alseres Pharmaceuticals, Inc. (ALSE) is ...
... patients who suffer a heart attack never have any warning ... problem is noncalcified plaque, a buildup of soft deposits embedded ... angiography or cardiac stress tests and prone to rupture ... success in detecting and measuring noncalcified plaque. In a pilot ...
... University Massey Cancer Center researchers have identified that a ... chronic myelogenous leukemia cells previously resistant to conventional forms ... a cancer of the bone marrow caused by a ... common forms of leukemia. Imatinib mesylate, or Gleevec, is ...
... N.J., May 29 The Musculoskeletal Transplant,Foundation (MTF) ... needed for cartilage and joint repair for injured ... be given priority in obtaining,tissue used for cartilage ... in short supply, these types of tissue are ...
Cached Medicine News:Health News:World No Tobacco Day Sounds Urgent Call for Nations to Fight Tobacco Use, Save Lives 2Health News:World No Tobacco Day Sounds Urgent Call for Nations to Fight Tobacco Use, Save Lives 3Health News:Perot Systems and Sinai Health System Extend Revenue Cycle Solutions Contract 2Health News:Alseres Pharmaceuticals, Inc. Announces 2008 Annual Stockholders Meeting 2Health News:New method effective in detecting dangerous coronary plaque 2Health News:New method effective in detecting dangerous coronary plaque 3Health News:Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy 2
(Date:7/11/2014)... July 11, 2014 Neurelis, Inc. ("Neurelis") today ... end the option held by Biotie to purchase Neurelis, ... of NRL-1 (intranasal diazepam) for pediatric and adult epilepsy ... the past year, Biotie has advanced the development program ... the pivotal clinical work required for NDA submission to ...
(Date:7/10/2014)... 10, 2014  Breg, Inc., a premier provider ... the FreeRunner™ knee brace with new innovations to ... mal-tracking return to active lifestyles.  FreeRunner,s patent-pending design ... providing support when patients need it most, and ... Patellofemoral issues are the most common ...
(Date:7/10/2014)... Utah , July 10, 2014  BC Technical, ... and MiE America , Inc., a leading provider ... entered into a long-term agreement naming BC Technical as ... US. MiE and BC Technical announced ... agreement to establish BC Technical as the service and ...
Breaking Medicine Technology:Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... Sept. 12, 2011 International Isotopes Inc (OTC Bulletin Board: ... an update of the Company,s general business status, particularly, the ... well as to discuss progress of its ongoing plans for ... Isotopes Inc General Business Update. When: ...
... Lewis County today launched a new program to help ... Through a partnership with the National Association of Counties (NACo), ... a card that offers an average of 24 percent savings ... The card can be used by those who do not ...
Cached Medicine Technology:International Isotopes Inc Announces Conference Call to Give an Update on the Company's General Business Status 2Lewis County Introduces Prescription Discount Card to Help Alleviate High Costs 2
Full Handle Laseredge Spoon Blade Knife, 3.0 mm angled double bevel. Blade dimension: 11.0 mm (L) x 3.0 mm (W). Cut: 320....
Full Handle Laseredge Slit Blade Knife, 3.2 mm angled bevel up. Blade tip dimension: 14.4 mm x 3.2 mm x 3.7 mm....
Full Handle Laseredge Slit Blade Knife, 3.2 mm straight. Blade tip dimension: 14.4 mm x 3.2 mm x 3.7 mm....
Full Handle Laseredge Slit Blade Knife, 3.0 mm angled bevel up. Blade tip dimension: 14.4 mm x 3.0 mm x 3.7 mm....
Medicine Products: