Navigation Links
Improving anxiety treatment through the help of brain imaging: A potential future treatment strategy
Date:5/8/2008

Philadelphia, PA, May 8, 2008 Wouldnt it be nice if our doctors could predict accurately whether we would respond to a particular medication" This question is important because research studies provide information about how groups of patients tend to respond to treatments, but inevitably, differences among groups of patients with the same diagnosis mean that findings about groups of patients may not apply to individuals from those groups. Personalized medicine is the effort to match particular treatments to particular patients on the basis of genetic information or other biological markers. In a new article published in Biological Psychiatry on May 1st, researchers report their findings on the potential use of functional magnetic resonance imaging (fMRI) to match treatments for patients with generalized anxiety disorder (GAD).

Whalen and colleagues recruited subjects diagnosed with GAD who underwent brain scans both before and after treatment with venlafaxine, an antidepressant that has been shown to be effective in treating anxiety. During the fMRI scans, the participants responses to viewing pictures of fearful facial expressions were measured. Dr. Paul Whalen, corresponding author for this article, explains, We focused our study on a regulatory circuit in the brain involving the amygdala, an area that serves to detect the presence of threatening information, and the prefrontal cortex, an area that functions to control these threat responses when they are exaggerated or unnecessary.

The researchers found that approximately two thirds of the patients experienced relief from their anxiety symptoms after treatment, and of those who improved, some responded better than others. As hypothesized, the fMRI data predicted who would do well on the drug and who would not. According to Dr. Whalen, subjects who showed high prefrontal cortex activation together with low amygdala activation in response to the fearful faces reported a significant decrease in their anxiety symptoms, while those showing the reverse brain activation pattern (i.e., high amygdala, low prefrontal) did not.

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments on this study, There is a tremendous need for biomarkers of treatment response. The paper by Whalen et al. joins a small group of preliminary studies suggesting that fMRI research might contribute to the effort to develop treatment biomarkers. He cautions, though, that while these are exciting data, we have yet to see this type of biomarker receive sufficient rigorous validation to be useful for matching patients to existing treatments or to test new potential treatment mechanisms. Dr. Whalen acknowledges the preliminary nature of their findings, noting that future studies will be needed to determine the exact impact that brain imaging might have in helping physicians prescribe anti-anxiety medications, but he concludes that while a brain scan would be a relatively expensive addition to the prescribing procedure, this cost pales in comparison to the amount of time, money and angst invested by patients who go through multiple medications and dosages looking for relief.


'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Medical research is essential to improving the economy and bettering lives
2. Location! Location! Location technologies are improving NHS care
3. Chrysler LLC Chairman and CEO Bob Nardelli and Chrysler Foundation Recognized by Larry King Cardiac Foundation for Dedication to Improving Lives of Others
4. Improving Access to Safe Water, Sanitation, Hygiene Requires Better Decision-Making Tools, Finds Joint Wilson Center-Pacific Institute Report
5. Improving survival rates among users of left ventricular assist devices
6. Improving quality of life for brain tumor patients
7. National Council on Disability Recommends Improving Federal Data Describing the Status of Americans with Disabilities
8. Zsweet(R) Improving Life for Diabetics and the Overweight
9. New Pennsylvania Dental Association President Will Focus on Improving Access to Care
10. ACS Systems Improving Delivery of Healthcare in Malta
11. CDC and Retail Health Clinic Leaders Explore Improving Prevention, Surveillance and Emergency Response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... THR ... “NANOCALM 300” Microemulsified Hemp Extract. This premier nanoemulsified CBD product utilizes Quicksilver ... the bloodstream. Far outpacing the absorption speed of all other products, ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... a contract to Quality Insights to help small practices in Delaware, New Jersey, ... Program, established by the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). ...
(Date:2/22/2017)... Cranbury, NJ (PRWEB) , ... February 22, 2017 ... ... full-service healthcare communications company, launched a new media platform connecting healthcare technology professionals ... which will be followed by a quarterly publication starting on March 1, announced ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pet obesity in the U.S. ... dogs, according to the Association for Pet Obesity Prevention (APOP). During the ninth annual ... issues such as the benefits of corn and grains, value of raw and organic ...
(Date:2/22/2017)... Dallas, TX (PRWEB) , ... February 22, 2017 ... ... of security threats. Yet with so many different solutions on the market, it ... through their choices, Texas Premier Locksmith offers a complimentary security consultation. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 2017 The top three ... Olympus Corporation, Nikon Corporation, and Leica Microsystems. Collectively ... the overall market in 2015. The oligopolistic market ... result-oriented research and development activities and mergers and ... on expanding their business to emerging economies as ...
(Date:2/22/2017)... and PUNE, India , February 22, 2017 ... was valued at $3,453 million in 2015 and is projected to reach $5,334 million ... implants segment held nearly two-fifths of the total market in 2015. ... ... ...
(Date:2/22/2017)... Feb. 22, 2017  Known for selling everyday ... the widow of prominent California ... know something else about the British conglomerate that makes ... by attempting to steal her late husband,s invention, business ... operated by Dr. Gilbert until his violent death in ...
Breaking Medicine Technology: