Navigation Links
Improvement in prediction of blood clots in cancer patients

(WASHINGTON, September 9, 2010) For cancer patients, who have an increased risk of developing venous thromboembolism (VTE) due to a hyperactive blood coagulation system, there is now an enhanced risk model to predict their chance of developing blood clots, according to a recent study published today in Blood, the journal of the American Society of Hematology. VTE, the formation of blood clots in the veins, develops in up to 20 percent of cancer patients and is one of the leading causes of death among this patient population. Patients with hematologic malignancies (blood cancers), particularly those with lymphoma and multiple myeloma, have relatively high rates of VTEresults from this study found that 7.2 percent of lymphoma patients and 7.4 percent of the total study population developed VTE, compared to an estimated general population incidence rate of .001 percent.1

"Because the risk of VTE is not equal in all cancer patients and anticoagulation in cancer patients results in a higher risk of bleeding complications, categorizing cancer patients according to their VTE risk is important," said Ingrid Pabinger, MD, professor at the Medical University of Vienna and lead author of the study. Patients with high risk of VTE may benefit from routine thrombophrophylaxis, preventive treatment for blood clotting, while low-risk patients tend to have a higher bleeding risk and may not be the best candidates for routine anticoagulation treatments.

Although there is a current risk prediction model for VTE in cancer patients, which includes factors such as site of cancer, body mass index, platelet and leukocyte counts, and hemoglobin levelall known to increase the risk of cancer-associated VTEthe new model also incorporates two new biomarkers, soluble P-selectin (sP-selectin) and D-dimer, to further stratify patients into high- and low-risk groups. sP-selectin is a cell adhesion molecule that promotes blood clot formation and D-dimer is a protein found in the blood that is used to detect abnormal blood clot formation and breakdown. Both have been previously identified as predictive biomarkers for cancer-associated VTE and their addition into the risk prediction model improves the accuracy of the classification of the patients into different risk categories. According to this new risk scoring model, about one-third (35 percent) of cancer patients in the highest risk category developed VTE during the study, as opposed to only one percent of patients in the lowest risk category.

In this study, researchers examined 819 cancer patients enrolled in the Vienna Cancer and Thrombosis Study (CATS), an ongoing prospective observational study performed at the Medical University of Vienna, between October 2003 and December 2008. Cancer types included: brain, breast, lung, stomach, colorectal, pancreatic, kidney, prostate, and hematologic malignancies such as myeloma and lymphoma.

"Our expanded model demonstrates that cancer patients at a very high risk of VTE can be defined more precisely," said Cihan Ay, MD, hematology fellow at the Clinical Division of Hematology and Hemostaseology at the Medical University of Vienna and co-author of the study. "This new model can help clinicians tailor their anticoagulant therapy and improve blood clotting prevention, which will maximize the clinical benefit and cost-effectiveness of disease prevention and minimize the risk of bleeding complications."


Contact: Lindsey Love
American Society of Hematology

Related medicine news :

1. New antiviral drug shows promise for dramatic improvement in hepatitis C treatment
2. New anti-viral drug shows promise for dramatic improvement in hepatitis C treatment
3. Drug study shows improvement in major orthopedic surgery care
4. Green And Greener Survey Shows Hospitals Embrace Environmentally Sustainable Practices, Though Room for Improvement Remains
5. Network Latency Improvement Creates One of the Fastest Routes between Chicago and Newark/New York City
6. Comparison of available breast cancer risk assessment tools shows room for improvement
7. Global Summit on International Breast Health Targets Breast Health Improvements in Developing Countries, June 9-11, 2010, in Chicago
8. Patient-reported outcomes study shows improvements in quality of life among patients after 1 year of treatment with TYSABRI
9. Cosmetic and Plastic Surgery Web Site Announces Improvements to the Patient Process of Finding Cosmetic Doctors in Their Area
10. Long Island Children's Orthodontist Announces Office Improvements And New Staff Member
11. Lifesaving Bills Filed in Florida Legislature to Guarantee Patient Safety Improvements
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices in ... that delves into an array of issues that are presently affecting Americans. Dedicated to ... dialogue, this show is changing the subjects consumers focus on, one episode at a ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men ... prominent nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown ... helped advance the healthcare industry as a whole through their advocacy and professional ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... workshops to discuss bioavailability and the need to integrate dose form selection in ... collaboration with OBN, the membership organization supporting and bringing together the UK’s emerging ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes ... titles work with any font, giving users limitless opportunities to stylize and create ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... -- --> --> ... potential to save costs, improve treatment quality and accelerate ... exploited as yet. Here, particular emphasis is placed on ... tablet or directly at the patients, bedside. ... -->      (Photo: ) ...
(Date:11/27/2015)... -- Research and Markets ( ) has announced ... 2015-2019" report to their offering. ... the author the present scenario and growth prospects of ... the market size, the report considers revenue generated from ... and copper IUDs. The report forecasts the global intrauterine ...
(Date:11/26/2015)... 26, 2015 Un nuevo enfoque ... para el cáncer avanzado.   --> ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... inmunoterapia con la terapia fotodinámica de Bremachlorin para el ... . --> Clinical Cancer Research . ...
Breaking Medicine Technology: