Navigation Links
Improved rodent trials can speed cancer drug development
Date:10/28/2008

Better design of rodent trials could reduce the cost and time required for cancer drug development, according to a commentary in the October 28 online issue of the Journal of the National Cancer Institute.

Cancer drug development is a multistep process that involves in vitro tests, animal studiesoften with rodent models of diseaseand human clinical trials. Inadequately designed rodent studies have led to missteps and delays in previous drug development programs.

In a commentary, Melinda Hollingshead, D.V.M., Ph.D., of the developmental therapeutics program at the National Cancer Institute in Frederick, Md., reviews the critical facets of a well-designed rodent trial. The key steps include the identification and use of an appropriate animal model and study endpoints, correct statistical evaluation of the data, proper randomization, and inclusion of a sufficient number of animals for statistically meaningful data. Hollingshead also argues for the inclusion of enough methodological detail in the published article to allow readers to fully interpret and understand the implications of those data.

Using examples from the peer-reviewed literature, she illustrates the consequences of improper experimental design. Although properly designed experiments may cost more money or require the use of more animals initially, they ultimately save resources and are necessary to streamline the whole process, she argues.

"The conclusions drawn from a series of studies are only as good as the data on which they are based. The impact of high-quality experimental design, methodology, and data interpretation cannot be overstated," she writes. "Along with a savings in animals, there will likely be a concomitant savings in costs and time, contributing to an overall reduction in drug development costs."


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Smart for Life(TM) Announces the New and Improved Bagel
2. Coleman Natural(R) Foods Launches New and Improved Website
3. New EPA Lead Standard Significantly Improved to Protect Kids Health
4. Ovarian and Endometrial Cancer Patients Experience Improved Outcomes When Treated First by a Gynecologic Oncologist
5. Improved healthfinder.gov Makes Health Information Quicker and Easier to Use
6. Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation
7. eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes
8. New Research Study Seeks Improved Quality of Life for People in the Future with Schizophrenia
9. Journal of Cardiovascular Electrophysiology Publishes Data Showing Ranolazine Shortened QT Interval and Improved Cardiac Relaxation in Study of Patients With Long QT Syndrome
10. STEN Corporation Reports 2008 Third-Quarter Revenue of $5 Million and Improved Results From Operations
11. Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2017)... ... January 13, 2017 , ... According to a December 9 ... may lower the risk of type 2 diabetes, Alzheimer’s, and cardiovascular disease. Southern ... wellness benefits linked to a Mediterranean diet are only some of the many ...
(Date:1/13/2017)... ... 2017 , ... A January 10 article in the Daily Star ... publication, with an emphasis on some new techniques that the publication says are becoming ... more casually to his patients and colleagues as Dr. J, comments that the best ...
(Date:1/13/2017)... ... January 13, 2017 , ... People who have sensitive teeth are about ... they brush their teeth. Sadly, most dental hygiene products in the market contain chemical ... For these people, continuing their daily oral care routine to keep their teeth white ...
(Date:1/13/2017)... ... 2017 , ... The Joint Corp. was recently ranked in ... by entrepreneurs and franchisors as a top competitive measurement, the Franchise 500® ranked ... strength and stability, growth rate, and brand power. , “It is always an ...
(Date:1/13/2017)... ... January 13, 2017 , ... One way to obtain a green ... if they can show their work is in the national interest. There are two ... having to be sponsored by an employer; and 2) the submission is made directly ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... NEW YORK , Jan. 12, 2017  Rosen ... the filing of a class action lawsuit on behalf ... ALXN ) from February 10, 2014 through November ... to recover damages for Alexion investors under the federal ... action, go to http://rosenlegal.com/cases-991.html or call ...
(Date:1/13/2017)... , Jan. 13, 2017 Over the last 10 years ... rapidly (6% – 10% yoy) and are expected to deliver remarkable future ... region, followed by Thailand , the Philippines ... and Singapore .  A member of the G20 and ... almost 40% of the SEA,s economic output and the largest pharma manufacturing ...
(Date:1/13/2017)... -- ... Research and Markets has announced the addition of the ... offering. The disease is divided into two categories ... melanoma, which can be treated with surgery, and advanced melanoma, which ... therapy aiming to prevent disease re-occurrence, and advanced therapies aiming to ...
Breaking Medicine Technology: