Navigation Links
Improved rodent trials can speed cancer drug development
Date:10/28/2008

Better design of rodent trials could reduce the cost and time required for cancer drug development, according to a commentary in the October 28 online issue of the Journal of the National Cancer Institute.

Cancer drug development is a multistep process that involves in vitro tests, animal studiesoften with rodent models of diseaseand human clinical trials. Inadequately designed rodent studies have led to missteps and delays in previous drug development programs.

In a commentary, Melinda Hollingshead, D.V.M., Ph.D., of the developmental therapeutics program at the National Cancer Institute in Frederick, Md., reviews the critical facets of a well-designed rodent trial. The key steps include the identification and use of an appropriate animal model and study endpoints, correct statistical evaluation of the data, proper randomization, and inclusion of a sufficient number of animals for statistically meaningful data. Hollingshead also argues for the inclusion of enough methodological detail in the published article to allow readers to fully interpret and understand the implications of those data.

Using examples from the peer-reviewed literature, she illustrates the consequences of improper experimental design. Although properly designed experiments may cost more money or require the use of more animals initially, they ultimately save resources and are necessary to streamline the whole process, she argues.

"The conclusions drawn from a series of studies are only as good as the data on which they are based. The impact of high-quality experimental design, methodology, and data interpretation cannot be overstated," she writes. "Along with a savings in animals, there will likely be a concomitant savings in costs and time, contributing to an overall reduction in drug development costs."


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Smart for Life(TM) Announces the New and Improved Bagel
2. Coleman Natural(R) Foods Launches New and Improved Website
3. New EPA Lead Standard Significantly Improved to Protect Kids Health
4. Ovarian and Endometrial Cancer Patients Experience Improved Outcomes When Treated First by a Gynecologic Oncologist
5. Improved healthfinder.gov Makes Health Information Quicker and Easier to Use
6. Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation
7. eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes
8. New Research Study Seeks Improved Quality of Life for People in the Future with Schizophrenia
9. Journal of Cardiovascular Electrophysiology Publishes Data Showing Ranolazine Shortened QT Interval and Improved Cardiac Relaxation in Study of Patients With Long QT Syndrome
10. STEN Corporation Reports 2008 Third-Quarter Revenue of $5 Million and Improved Results From Operations
11. Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Rock, AR (PRWEB) , ... October 13, 2017 ... ... firm with locations throughout Arkansas that offers insurance and financial preparation services, is ... benefit the Rock City Rescue organization. , Rock City Rescue is a locally ...
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new ... at MIBio 2017 in Cambridge, U.K on ... in biopharmaceutical samples with unprecedented speed and sensitivity while using far ... Membrane Imaging. ... particle analysis system ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: