Navigation Links
Improved rodent trials can speed cancer drug development
Date:10/28/2008

Better design of rodent trials could reduce the cost and time required for cancer drug development, according to a commentary in the October 28 online issue of the Journal of the National Cancer Institute.

Cancer drug development is a multistep process that involves in vitro tests, animal studiesoften with rodent models of diseaseand human clinical trials. Inadequately designed rodent studies have led to missteps and delays in previous drug development programs.

In a commentary, Melinda Hollingshead, D.V.M., Ph.D., of the developmental therapeutics program at the National Cancer Institute in Frederick, Md., reviews the critical facets of a well-designed rodent trial. The key steps include the identification and use of an appropriate animal model and study endpoints, correct statistical evaluation of the data, proper randomization, and inclusion of a sufficient number of animals for statistically meaningful data. Hollingshead also argues for the inclusion of enough methodological detail in the published article to allow readers to fully interpret and understand the implications of those data.

Using examples from the peer-reviewed literature, she illustrates the consequences of improper experimental design. Although properly designed experiments may cost more money or require the use of more animals initially, they ultimately save resources and are necessary to streamline the whole process, she argues.

"The conclusions drawn from a series of studies are only as good as the data on which they are based. The impact of high-quality experimental design, methodology, and data interpretation cannot be overstated," she writes. "Along with a savings in animals, there will likely be a concomitant savings in costs and time, contributing to an overall reduction in drug development costs."


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Smart for Life(TM) Announces the New and Improved Bagel
2. Coleman Natural(R) Foods Launches New and Improved Website
3. New EPA Lead Standard Significantly Improved to Protect Kids Health
4. Ovarian and Endometrial Cancer Patients Experience Improved Outcomes When Treated First by a Gynecologic Oncologist
5. Improved healthfinder.gov Makes Health Information Quicker and Easier to Use
6. Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation
7. eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes
8. New Research Study Seeks Improved Quality of Life for People in the Future with Schizophrenia
9. Journal of Cardiovascular Electrophysiology Publishes Data Showing Ranolazine Shortened QT Interval and Improved Cardiac Relaxation in Study of Patients With Long QT Syndrome
10. STEN Corporation Reports 2008 Third-Quarter Revenue of $5 Million and Improved Results From Operations
11. Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... VEGAS, NEV. (PRWEB) , ... August 22, 2017 ... ... American Academy of Anti-Aging Medicine recently spoke at a popular international aesthetics conference ... therapy has had on restoring his patients’ health and his growing practice. , ...
(Date:8/22/2017)... ... ... past six years, Lightning Labels has sent out a call for users of its custom ... creativity of their designs. Submissions this year were open from May 18 to July 1 ... winners of the sixth annual Photo Contest, along with the prizes they've received:, ...
(Date:8/22/2017)... ... 2017 , ... Nurses at Apple Rehab Watch Hill , a nursing ... and certification in Closed Pulse Irrigation™ (CPI) for wound care. This qualifies ... Centers for Medicare and Medicaid Services, to have a CPI machine that will provide ...
(Date:8/22/2017)... ... August 22, 2017 , ... “To Walk Away”: a captivating and ... named Edward Koontz. “To Walk Away” is the creation of published author, Larry R. ... two hundred manuscripts in chemistry and religion, as well as four novels. , ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... ... heart-wrenching story of child abuse and neglect, and the struggles faced while hoping ... is the creation of published author, Judy Von Bernewitz, who spent 13 years ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... , Aug. 17, 2017 MJAC2017 , the ... Canna Broadcast Media, today reveals its leading lineup. ... Inc., a global cannabis innovator specializing in the development of ... the conference. MassRoots, Rambridge™ and The Green Organic Dutchman are ... and Namaste Vapes™ as silver sponsors. ...
(Date:8/15/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: DPLO), is ... residents. Naloxone is available without ... retail pharmacy, G-3320 Beecher Road. ... Drug Administration, is intended to block or reverse the ... loss of consciousness. The medication is often carried by ...
(Date:8/14/2017)... and PETACH TIKVAH, Israel ... (NASDAQ: BCLI), a leading developer of adult stem cell ... second quarter ending June 30, 2017. ... of preparing for our pivotal Phase 3 trial to ... Lebovits , President and Chief Executive Officer of BrainStorm. ...
Breaking Medicine Technology: