Navigation Links
Improved rodent trials can speed cancer drug development

Better design of rodent trials could reduce the cost and time required for cancer drug development, according to a commentary in the October 28 online issue of the Journal of the National Cancer Institute.

Cancer drug development is a multistep process that involves in vitro tests, animal studiesoften with rodent models of diseaseand human clinical trials. Inadequately designed rodent studies have led to missteps and delays in previous drug development programs.

In a commentary, Melinda Hollingshead, D.V.M., Ph.D., of the developmental therapeutics program at the National Cancer Institute in Frederick, Md., reviews the critical facets of a well-designed rodent trial. The key steps include the identification and use of an appropriate animal model and study endpoints, correct statistical evaluation of the data, proper randomization, and inclusion of a sufficient number of animals for statistically meaningful data. Hollingshead also argues for the inclusion of enough methodological detail in the published article to allow readers to fully interpret and understand the implications of those data.

Using examples from the peer-reviewed literature, she illustrates the consequences of improper experimental design. Although properly designed experiments may cost more money or require the use of more animals initially, they ultimately save resources and are necessary to streamline the whole process, she argues.

"The conclusions drawn from a series of studies are only as good as the data on which they are based. The impact of high-quality experimental design, methodology, and data interpretation cannot be overstated," she writes. "Along with a savings in animals, there will likely be a concomitant savings in costs and time, contributing to an overall reduction in drug development costs."


Contact: Liz Savage
Journal of the National Cancer Institute

Page: 1

Related medicine news :

1. Smart for Life(TM) Announces the New and Improved Bagel
2. Coleman Natural(R) Foods Launches New and Improved Website
3. New EPA Lead Standard Significantly Improved to Protect Kids Health
4. Ovarian and Endometrial Cancer Patients Experience Improved Outcomes When Treated First by a Gynecologic Oncologist
5. Improved Makes Health Information Quicker and Easier to Use
6. Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation
7. eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes
8. New Research Study Seeks Improved Quality of Life for People in the Future with Schizophrenia
9. Journal of Cardiovascular Electrophysiology Publishes Data Showing Ranolazine Shortened QT Interval and Improved Cardiac Relaxation in Study of Patients With Long QT Syndrome
10. STEN Corporation Reports 2008 Third-Quarter Revenue of $5 Million and Improved Results From Operations
11. Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... For the millions of ... Hollister Incorporated has launched the VaPro Plus Pocket™ touch free hydrophilic intermittent catheter. ... touch free catheter portfolio,” said Michael Gresavage, Vice President North America. "We designed ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... of Excellence (BHCOE) today announced that the organization has awarded Education and Developmental ... with a Distinguished Award. The award celebrates exceptional special needs providers that excel ...
(Date:12/1/2015)... ... 01, 2015 , ... McLean, VA., December 1, 2015 - ... per sprint agile development contract to support the National Geospatial-Intelligence Agency's (NGA) IT ... software engineering, infrastructure, as well as operations and sustainment support to the NGA’s ...
(Date:12/1/2015)... Auburn, CA (PRWEB) , ... December 01, 2015 ... ... software and clinical solutions for the care management and population health arenas, is ... on providing clinical and cost containment services, has successfully implemented the ACUITY Complete ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... has selected 10 semi-finalists to head to Las Vegas for CES 2016, the world’s ... including CEO of Consumer Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Dec. 1, 2015   Nottingham Spirk , ... announced the publication of a free whitepaper ... Medical Market". The whitepaper gives medical product companies, ... penetrating this lucrative segment. Nottingham Spirk ... to manage their own health, save money (i.e., ...
(Date:12/1/2015)... 2015 Array BioPharma Inc. (Nasdaq: ... Chief Executive Officer, Ron Squarer , ... Conference in New York.  The public is ... a webcast on the Array BioPharma website. ... --> , --> ...
(Date:12/1/2015)... , BANGALORE, India and ... N.V. (NASDAQ, TASE: MYL) today announced that it expects ... and for developing country markets funded by international donors, ... mg + Efavirenz 400 mg) for $99 per patient, ... Initiative (CHAI) to develop TLE400. The significantly reduced price ...
Breaking Medicine Technology: