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Improved method of electrical stimulation could help treat damaged nerves
Date:11/21/2011

BOSTON Functional electrical stimulation (FES) was developed to help return lost function to patients with upper and lower extremity injuries and spinal cord injuries, among other applications. However, the devices, which work by stimulating neuronal activity in nerve-damaged patients, have a potential shortcoming in that the electrical currents needed for the treatment to work can also send errant signals to surrounding nerves, resulting in painful side effects.

Earlier this fall, a plastic surgery research team at Beth Israel Deaconess Medical Center (BIDMC) and an engineering team from the Massachusetts Institute of Technology (MIT), described a new method of nerve stimulation that reduces the device's electrical threshold by 40 percent, compared with traditional FES therapy. Reported in the October 23 Advance On-line issue of the journal Nature Materials, the findings could help researchers develop a safer, more efficient FES therapy with fewer side effects.

"This new device works by manipulating the concentration of charged ions surrounding the nerve," explains co-senior author Samuel J. Lin, MD, a surgeon in BIDMC's Divisions of Plastic Surgery and Otolaryngology and Assistant Professor of Surgery at Harvard Medical School. "This could potentially mean reduced risk to surrounding nerves because less electrical current is required to stimulate the affected nerve." The researchers additionally discovered that they could use the device to block signals in nearby nerve fibers, which could help prevent unwanted muscle contractions.

The research team, led by Lin and MIT Associate Professor Jongyoon Han, PhD, determined that by altering calcium ion concentrations in the fluid surrounding the nerves they could adjust the electrical impulses.

"Nerve fibers fire their signals based on the message they receive from the interaction of ions, or charged particles," explains coauthor Ahmed M.S. Ibrahim, MD, a Research Fe
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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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