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Improved lesion detection with time-of-flight PET scans affirmed
Date:3/2/2011

For the first time, quantitativenot qualitativedata analysis has demonstrated that time-of-flight (TOF) positron emission tomography (PET) scans can improve cancer detection. Research published in the March issue of the Journal of Nuclear Medicine shows that oncologic TOF fluorodeoxyglucose (FDG) PET scans yielded significant improvements in lesion detection of lung and liver cancers over all contrasts and body mass indexes.

Conventional PET scans create images by detecting gamma rays produced by radioisotopes that are injected into the body. Although these conventional scans track where the gamma rays go, they don't consider the time it takes for each gamma ray to reach the detector. TOF PET scans do take into account the travel time, which results in improved image signal-to-noise.

"What's aimed to objectively quantify the improvement in lesion detection that can be achieved with whole-body TOF FDG PET," said Joel S. Karp, one of the authors of the study "Improvement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET." "In contrast with previously published studies that reported comparison of TOF and non-TOF PET using simulated data or measured data with physical phantoms, this study used whole-body patient data in order to encompass unique about this study is that we a large range of realistic activity distributions and patient body types."

To create a lesion-present clinical study while ensuring perfect knowledge of the presence and location of each lesion, 10-mm spheric lesions were added to disease-free bed positions, yielding fused lesion-present studies. These studies appropriately corrected for the body's attenuation so that the presence or absence of the lesions was similar to that of actual patient studies.

TOF PET scans were done, and researchers used a numeric observeras opposed to a human observerto rapidly detect a large number of conditions. The TOF PET images were compared to conventiona
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Contact: Susan Martonik
smartonik@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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