Navigation Links
Improved lesion detection with time-of-flight PET scans affirmed

For the first time, quantitativenot qualitativedata analysis has demonstrated that time-of-flight (TOF) positron emission tomography (PET) scans can improve cancer detection. Research published in the March issue of the Journal of Nuclear Medicine shows that oncologic TOF fluorodeoxyglucose (FDG) PET scans yielded significant improvements in lesion detection of lung and liver cancers over all contrasts and body mass indexes.

Conventional PET scans create images by detecting gamma rays produced by radioisotopes that are injected into the body. Although these conventional scans track where the gamma rays go, they don't consider the time it takes for each gamma ray to reach the detector. TOF PET scans do take into account the travel time, which results in improved image signal-to-noise.

"What's aimed to objectively quantify the improvement in lesion detection that can be achieved with whole-body TOF FDG PET," said Joel S. Karp, one of the authors of the study "Improvement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET." "In contrast with previously published studies that reported comparison of TOF and non-TOF PET using simulated data or measured data with physical phantoms, this study used whole-body patient data in order to encompass unique about this study is that we a large range of realistic activity distributions and patient body types."

To create a lesion-present clinical study while ensuring perfect knowledge of the presence and location of each lesion, 10-mm spheric lesions were added to disease-free bed positions, yielding fused lesion-present studies. These studies appropriately corrected for the body's attenuation so that the presence or absence of the lesions was similar to that of actual patient studies.

TOF PET scans were done, and researchers used a numeric observeras opposed to a human observerto rapidly detect a large number of conditions. The TOF PET images were compared to conventional PET images (the same data reconstructed without TOF information) to determine improvement in lesion detection as a function of lesion location, scan time, contrast and body mass index.

Improved lesion detection was observed in the TOF PET scans, with the greatest gains achieved in the shortest-acquisition studies and in the subjects with a BMI of 30 or more. Also of notethe greatest gain in performance was achieved at the lowest lesion contrast and the smallest gain in performance at the highest lesion contrast.

Nuclear medicine technologists and physicians may be able to take advantage of the gain achieved with TOF PET to reduce scanning time, therefore increasing patient comfort and minimizing patient motion. They may also be able to reduce the injected radiopharmaceutical dose, thereby reducing the exposure of patients and health professionals to radiation.


Contact: Susan Martonik
Society of Nuclear Medicine

Related medicine news :

1. Exercise Success for People Over 50: Reports of Improved Fitness, Circulation and Balance
2. Medical Transcription Services and EHR Provider MxSecure Launches New Enhanced Website with Goal of Improved Physician Productivity
3. Small to Mid-Sized Hospitals Turn to Orion Health to Implement Health IT Solutions for Improved Patient Care and Outcomes
4. Drug Improved Survival in Mice With Cystic Fibrosis
5. The Logo Launches New and Improved Website
6. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
7. TeraMedica Unveils Improved Univision, Now Offering a Multi-Layer Enterprise Viewing Platform
8. An improved method for calculating tumor growth
9. Improved doctor-pharmacist collaboration needed: study
10. Improved patient care with telemonitoring
11. Improved device provides more rapid, comprehensive analysis of circulating tumor cells
Post Your Comments:
(Date:11/24/2015)... UT (PRWEB) , ... November 24, 2015 , ... It ... Magazine. For a business, it is critical that the first impression be positive and ... they are not likely to buy anything or want to return. They will also ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... their knowledge and experiences at a live taping of the next CURE ... the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel & Conference ...
(Date:11/24/2015)... ... ... Aided by seed funding from the Ron Foley Foundation, researchers at Western ... how to detect and treat pancreatic cancer (PC). , WCHN researchers will focus ... (ncRNA), genetic material that is present in the blood of patients with PC. ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... its exceptional customer service: the TrustDale certification. The award recognizes good companies for ... stone honing , tile and grout, and hard surface restoration company earned this ...
(Date:11/24/2015)... ... November 24, 2015 , ... World Patent Marketing ... a household invention that revolutionizes the vending machine industry by providing healthy and ... worth $2 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  Boston Scientific Corporation (NYSE: ... Oppenheimer 26th Annual Healthcare Conference on December 8, in ... Susie Lisa , vice president, Investor Relations, will participate ... beginning at approximately 8:35 a.m. ET. --> ... in a 30-minute question-and-answer session with the host analyst ...
(Date:11/24/2015)...   Renowned UAE ... s advice and insights on supplements and healthy diet ... 50% of Dubai residents are not ...   femMED launches comprehensive solutions for women , ... residents are not consuming enough to keep themselves healthy. A local ...
(Date:11/24/2015)... 2015 Abaxis, Inc. (NasdaqGS: ABAX ), ... for the medical, research, and veterinary markets worldwide, announced ... will present at the 27 th Annual Piper ... 11:30 a.m. ET. The conference will be held at ... York City . Abaxis, Inc. is ...
Breaking Medicine Technology: