Navigation Links
Improved identification of war wound infections promises more successful treatment
Date:5/29/2014

War wounds that heal successfully frequently contain different microbial species from those that heal poorly, according to a paper published ahead of print in the Journal of Clinical Microbiology. These and other findings have important implications for improving wound healing, says first author Nicholas Be of Lawrence Livermore National Laboratory, Livermore, California.

The problem the researchers were addressing is that culture-based identification, which has been used to assay war wound infections, misses the many species that are difficult or impossible to culture. But Be and his collaborators posited that using microarrays and whole genome sequencing to detect microbial species in wound samples would reveal infections caused by microbes that cannot be cultured, as these molecular methods can detect all species for which reference DNA is available.

"We also hypothesized that different microorganisms could be associated with successful or unsuccessful healing, and we felt that this information could be used for guiding medical treatment," says Be.

In the study, the investigators found that genetic sequences from certain bacteria, including Pseudomonas species and Acinetobacter baumannii, were frequently observed in wounds that failed to heal, while bacteria typically associated with the gastrointestinal system, such as E. coli and Bacteroides species, were found in wounds that did heal successfully.

"This surprising finding further emphasizes the need for specific molecular detection," says Be. "We also observed via whole genome sequencing that the complex microbial populations present in wounds vary between patients and change over time in a single patient, further emphasizing the need for personalized treatment of individual wounds."

The investigators examined 124 wound samples from 61 wounds in 44 patients injured in combat in Iraq and Afghanistan. They used a microbial detection microarray developed at Lawrence Livermore National Laboratory, which contains DNA probes capable of detecting any microorganisms that have previously been sequenced.

"This represents a cost-effective, high-throughput platform for analysis of wound infections," says Be. A subset of samples was also subjected to whole genome sequencing.

"Information on the presence of specific bacteria that more significantly affect the success of the healing response could guide therapy and allow for more accurate prediction of outcome," says Be. "More effective, specific, and timely diagnosis of infection would improve treatment, accelerate rehabilitation, and decrease the length of hospital stays."

The manuscript can be found online at http://bit.ly/asmtip0514i. The final version of the article is scheduled for the July 2014 issue of the Journal of Clinical Microbiology.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Despite economic blows, infant health has improved among US poor
2. E-cigarette use for quitting smoking is associated with improved success rates
3. Donor livers preserved and improved with room-temperature perfusion system
4. Aspirin use appears linked with improved survival after colon cancer diagnosis
5. MATH, HPV status in HNSCC patients effective markers of improved patient outcome
6. Researchers identify possible explanation for link between exercise & improved prostate cancer outcomes
7. Latest Research Shows Improved Long-Term Memory with Same Caffeine Level as 5-hour ENERGY® Shots
8. Personal health record associated with improved medication adherence
9. CEO of Simply G Media GJ Reynolds Discussed His Launch Of The New and Improved SimplyG.com Website on The BeachLifestyle Radio Show.
10. Improved Method of Securing IV Lines Invented by InventHelp Client (BIR-2159)
11. InventHelp Inventor Designs an Improved Sanitary Pad (PND-4272)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... PurhealthRX , a leading Health and Nutrition Company, is announcing the ... spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the amount ... into liquid products, while reducing costs to end users. , The team of researchers ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)...   West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today shared the results of a study highlighting ... intradermal administration of polio vaccines. The study results were ... 2017 by Dr. Ondrej Mach , Clinical Trials ... (WHO), and recently published in the journal Vaccine. ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology: