Navigation Links
Improper protein digestion in neurons identified as a cause of familial Parkinson's
Date:3/5/2013

NEW YORK, NY (March 5, 2013) Researchers at Columbia University Medical Center (CUMC), with collaborators at the Albert Einstein College of Medicine of Yeshiva University, have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells. The mutations block an intracellular system that normally prevents a protein called alpha-synuclein from reaching toxic levels in dopamine-producing neurons. The findings suggest that interventions aimed at enhancing this digestive system, or preventing its disruption, may prove valuable in the prevention or treatment of Parkinson's. The study was published March 3 in the online edition of the journal Nature Neuroscience.

Parkinson's disease is characterized by the formation of Lewy bodies (which are largely composed of alpha-synuclein) in dopamine neurons. In 1997, scientists discovered that a mutation in alpha-synuclein can lead to Lewy body formation. "But alpha-synuclein mutations occur in only a tiny percentage of Parkinson's patients," said co-lead author David L. Sulzer, PhD, professor of neurology, pharmacology, and psychiatry at CUMC. "This meant that there must be something else that interfered with alpha-synuclein in people with Parkinson's."

Dr. Sulzer and his colleagues suspected that a gene called leucine-rich repeat kinase-2 (LRRK2) might be involved. LRRK2 mutations are the most common mutations to have been linked to Parkinson's. The current study aimed to determine how these mutations might lead to the accumulation of alpha-synuclein.

"We found that abnormal forms of LRRK2 protein disrupt a critical protein-degradation process in cells called chaperone-mediated autophagy," said Dr. Sulzer. "One of the proteins affected by this disruption is alpha-synuclein. As this protein starts to accumulate, it becomes toxic to neurons." Delving deeper, the researchers found that LRRK2 mutations interfere with LAMP-2A, a lysosome membrane receptor
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Hope in stopping melanoma from spreading: Inhibiting protein prevents metastasis to lungs in mice
2. Selexis SA Announces Publication in Metabolic Engineering of Data Demonstrating Improvement of Therapeutic Protein Secretion with Engineered CHO Cells
3. Protein synthesis blocker may hold key to reducing effects of traumatic events
4. Discovery of executioner protein opens door to new options for stroke ALS, spinal cord injury
5. Researchers discover how to shutdown cancers powerful master protein
6. Protein balance key in preventing cancer
7. Resurrection of 3-billion-year-old antibiotic-resistance proteins
8. Researchers at the UH Cancer Center discover protein that may control the spread of cancer
9. Cell scaffolding protein fascin-1 is hijacked by cancer
10. BioTrust Low Carb Protein Review Revealed By BioTrust Nutrition Reviews
11. Data on novel IL-1 inhibitor protein for topical treatment of dry eye disease published
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Padre Murphy's and Owner Tom ... Pro Player Health Alliance (PPHA). The PPHA's passion ... getting everyone, including NFL greats, treated for obstructive sleep apnea ... groups supporting the cause in the valley. The most recent ...
(Date:1/22/2015)... 23, 2015 AngelWeddingDress, the premier women’s ... maternity wedding dresses. View website of AngelWeddingDress.com ... for maternity wedding dresses online for a bridal party. ... high quality for them. Its maternity wedding dresses are ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining ... policy . , Auto insurance quotes help many drivers ... longer necessary to call an agent or visit an agency ... a single website: http://autocarinsurancebest.com/ . , Every business who ...
(Date:1/22/2015)... Calif. (PRWEB) January 22, 2015 ... Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were ... their leadership in advancing biotechnology, biomedical science, medical ... and Olsen each received the “2014 Life Sciences ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the American ... effort to further promote visibility and adoption of the top ... AMA journals available via its subscription services, EBSCO will now ... , Long known as both a subscription agency and ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... Corporation,(Nasdaq: AIRM ) will report financial results for ... of the market on Wednesday, March 12,2008. The Company ... at 4:15 p.m. Eastern to discuss these results., ... 396-5640,(domestic) or (706) 643-0580 (international) or by accessing the ...
... March 5 Natalie Waples,an Ottawa based and ... Board: NTNI) http://www.naturalnutritioninc.com ,subsidiary InterACTIVE Nutrition International ... Championships (height class "E") held at,the Arnolds Sports ... ), The event was held from ...
... an Antarctic fish species that adopts a winter survival ... the journal PLoS ONE, the online journal from the ... (BAS) and the University of Birmingham reveal, for the ... puts itself on ice to survive the long Antarctic ...
... Dental Network of,America Inc. (DNoA) announced today the ... The new program is now being,utilized by Health Care ... Blue Cross and Blue Shield Plans in Illinois, New ... Blue Cross and Blue Shield,Association., Research continues to ...
... March 4 Secretary of Health,Dr. Calvin B. ... workers at,Edinboro University to discuss Governor Edward G. ... hundreds of thousands of uninsured adults,through his "Cover ... is critical to help prevent disease,successfully manage chronic ...
... N.J., March 4 ,Cathedral Healthcare System Inc. has ... interest, to settle allegations that it defrauded the ... The settlement resolves allegations that the Newark, N.J.-based,hospital ... order,to obtain enhanced reimbursement from the federal health ...
Cached Medicine News:Health News:Natural Nutrition's Spokesperson and Athlete Natalie Waples Wins 2008 Arnold Amateur Figure Championship 2Health News:Hibernation-like behavior in Antarctic fish -- on ice for winter 2Health News:Dental Network of America Inc. Launches Integrated Medical-Dental Health Program 2Health News:Dental Network of America Inc. Launches Integrated Medical-Dental Health Program 3Health News:Health Secretary Stops in Erie County to Call for Health Insurance for all Pennsylvanians 2Health News:Cathedral Healthcare System to Pay U.S. $5.3 Million to Resolve Allegations Involving Inflated Charges to Obtain Higher Medicare Reimbursement 2
(Date:1/23/2015)... CHAPEL HILL, N.C. , Jan. 23, 2015 For ... organizations are in dealing with payers. Likewise, the importance of ... payers - will only continue to grow as payer formularies ... patients access therapies. At the same time, managed ...
(Date:1/23/2015)... Partnership to Fight Chronic Disease (PFCD) released a public opinion poll ... new study analyzing the impact of increased cost sharing on patient ... to educate policy makers and the public on the costs of ... how the Iowa healthcare exchange could be ...
(Date:1/23/2015)... , Jan. 23, 2015  Immune Therapeutics, Inc. today announced the ... the compounding, packaging and distributing of its naltrexone tablets.  The ... United States . KRS Global is ... tablets in various strengths for individual patients in response to ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4
... With the support of Key Opinion Leaders clearly ... time and attention of KOLs is intensifying. But the ... for creating and maintaining KOL and physician relationships. ... landscape, Best Practices, LLC has published an updated MSL-focused ...
... 2011 CVS Caremark (NYSE: CVS ) ... President of CVS/pharmacy effective October 1, 2011.  With more ... Columbia, and Puerto Rico, CVS/pharmacy is one of the ... (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO) Cosby, 52, most recently served ...
Cached Medicine Technology:Pharma Medical Science Liaison Outreach Shifting Away from Traditional Company Sales Regions 2CVS Caremark Appoints Mark S. Cosby as President of CVS/pharmacy 2CVS Caremark Appoints Mark S. Cosby as President of CVS/pharmacy 3
... The GlucoWatch G2 Biographer is intended ... glucose levels in adults (aged 18 and ... with diabetes. Parents should supervise the use ... The G2 Biographer is intended to supplement, ...
... Worlds First Solid-State Three-Color Photocoagulator.,Retinal physicians ... purchase over 3,000 Lumenis multi-color photocoagulators.,For ... practice, the Novus Varia integrates green, ... a single, compact system that supports ...
... For complete capsular protection over 360°. ... secures the eyelet positioning under the ... contact with capsule and easier implantation. ... high myopia, uveitis, diabetic, sonulo-capsular laxity, ...
... is a device designed for permanent implantation ... removal surgery. It provides secondary capsular bag ... The CTR is a uniplanar, 270-degree, semi-circle ... absorbing polymethylmethacrylate (PMMA) with one manipulation eyelet ...
Medicine Products: