Navigation Links
Imprint of chemotherapy linked to inflammation in breast cancer survivors
Date:3/4/2014

Miller, chemotherapy was associated with increased markers of inflammation in the blood which correlated with fatigue.

"We had found that increased fatigue was similar no matter whether patients received chemotherapy before or after surgery," Torres says, "indicating that the timing of chemotherapy was less important than whether you got it in the first place."

In the current study, all the women went through partial mastectomy surgery. Some received varying forms of chemotherapy, and all received radiation at the end. They found that women who had been treated with chemotherapy exhibited changes in the methylation of the DNA in their white blood cells. Some of these changes were still present six months after radiation.

Methylation is an epigenetic alteration in DNA, which does not change the A/C/G/T "letter" information in the DNA but does change how that information is read by the cell, influencing whether a gene is turned on or off.

The researchers scanned hundreds of thousands of potential sites of methylation; only eight sites were reliably altered in women who received chemotherapy, and changes at half of those sites were visible six months later.

The biology connecting this handful of sites to inflammation remains unclear; the eight sites were not in genes that encode inflammatory signaling proteins secreted into the blood, for example. However, the methylation changes did correlate with increased levels of two inflammatory signaling proteins, IL-6 and sTNFR2, that have been associated with fatigue in breast cancer survivors.

Many chemotherapeutic agents are effective precisely because they damage DNA in cancer cells. While it was well known that chemotherapy induces epigenetic changes in cancer cells, this is the first study to identify epigenetic changes induced by chemotherapy in non-cancerous cells of the blood.

The authors hypothesize that chemotherapy may directly alter methylation stat
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study identifies protein that helps developing germ cells wipe genes clean of past imprints
2. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
3. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
4. Genetic predictor of breast cancer response to chemotherapy
5. Chemotherapys effect on overall survival seems to increase based on tumor size
6. Accelerated chemotherapy given before surgery benefits patients with muscle-invasive bladder cancer
7. Breast MRI helps predict chemotherapys effectiveness
8. Why chemotherapy fails
9. Overexpression of proteins 14-3-3 related to chemotherapy resistance
10. Chemotherapy effective for patients with resected SCLC or large-cell neuroendocrine carcinoma
11. Pediatric regime of chemotherapy proves more effective for young adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... Spring House, PA (PRWEB) May 28, 2015 ... Bruce Dalglish, today announced a just launched blog series ... corporate cultures. Hosted on the “R. Bruce Dalglish” ... by decades of R. Bruce Dalglish’s corporate experience. ... impact that positive workplace cultures have upon the overall ...
(Date:5/28/2015)... TX (PRWEB) May 28, 2015 Ticket Down ... friendly soccer match between Mexico and Argentina in ... in the world will compete on the pitch at AT&T ... one another in an international friendly on Tuesday, September 8th ... most talented nations in the world including some of the ...
(Date:5/28/2015)... Edmond, OK (PRWEB) May 28, 2015 ... pain relief lotion and products, today announced their best-selling lotion ... bottle. Real Time Pain Relief is an FDA registered OTC ... natural and herbal ingredients, such as Aloe Vera, Arnica, Capsicum, ... a low level of Menthol – only 1.25% – to ...
(Date:5/28/2015)... Hexagon Geospatial is pleased to announce ... of engineering, spatial data and mapping services, is using ... point clouds for urban change assessments in Bernalillo County, ... BHI Spatial Data Division implemented a countywide approach to ... Collected by a variety of different digital aerial camera ...
(Date:5/28/2015)... Cancer survivors who participated in the LIVESTRONG ... fitness and quality of life, according to research conducted ... Jennifer Ligibel, MD, senior physician in the Susan F. ... The findings will be presented at this year’s ... in Chicago. , The study, designed to ...
Breaking Medicine News(10 mins):Health News:R. Bruce Dalglish, CEO of Alliance Hospice, Introduces New Blog Series On Positive Corporate Culture 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 3Health News:Real Time Pain Relief Introduces New Four Ounce Pump Bottle for their Popular Pain Relief Lotion 2Health News:Hexagon Geospatial Supports Urban Change Detection Programs in New Mexico 2Health News:Hexagon Geospatial Supports Urban Change Detection Programs in New Mexico 3Health News:LIVESTRONG at the YMCA Program Shows Significant Gains for Cancer Survivor Participants 2Health News:LIVESTRONG at the YMCA Program Shows Significant Gains for Cancer Survivor Participants 3Health News:LIVESTRONG at the YMCA Program Shows Significant Gains for Cancer Survivor Participants 4
... DALLAS, April 6 As consumers continue to adopt ... their guests by adding new menu items to their ... of the first casual dining restaurant concepts to create ... to healthier items in 1993. Along with the addition ...
... Against a background of economic uncertainty, people across the ... terms of their wealth but also their health, according ... practice of DDB Worldwide Communications Group Inc.The study, recently ... Omnicom Group Inc., compares perceptions about health among more ...
... the First of Five New Markets Slated to Feature ... April 6 MoleSafe ( www.molesafe.com ), a company that ... has opened its second U.S. location in Albuquerque, New Mexico. ... Jersey, in 2008. MoleSafe originated in New Zealand, which is ...
... Information Workflow Drives Carefx,s Agenda at HIMSS Conference, ... 6 Carefx Corporation , ... existing systems and offers clinicians single, clinically relevant ... at this year,s Healthcare Information and Management Systems ...
... fund multiple sclerosis researchCHICAGO, April 6 The Illinois ... for MS education and awareness by purchasing the newest ... 4, 2009, the Lottery released "Dash! For Cash" to ... Cash" is the second instant game created to support ...
... Phase Focuses On Integration Of Health Information Exchange ComponentsCHICAGO, ... Harris Corporation (NYSE: HRS ) has been ... Network (NHIN) CONNECT contract by the Federal Health Architect ... Office of the National Coordinator. CONNECT is an ...
Cached Medicine News:Health News:Chili's Celebrates Women with Curves 2Health News:DDB Worldwide and M/A/R/C Research Find in Time of Economic Crisis: Health Is the New Wealth, Survey Shows Empowering Patients Is Key to Influence 2Health News:MoleSafe USA Opens Second Location in Albuquerque, New Mexico 2Health News:MoleSafe USA Opens Second Location in Albuquerque, New Mexico 3Health News:Carefx Showcases Expanded Fusionfx Solution Suite and Profiles Changing Roles of CIOs at Executive Roundtable 2Health News:Carefx Showcases Expanded Fusionfx Solution Suite and Profiles Changing Roles of CIOs at Executive Roundtable 3Health News:Carefx Showcases Expanded Fusionfx Solution Suite and Profiles Changing Roles of CIOs at Executive Roundtable 4Health News:Illinois Lottery Releases New MS Ticket, Dash! For Cash 2Health News:Illinois Lottery Releases New MS Ticket, Dash! For Cash 3Health News:Harris Corporation Awarded Follow-on Contract Option to Expand CONNECT Solution for Nationwide Health Information Network 2Health News:Harris Corporation Awarded Follow-on Contract Option to Expand CONNECT Solution for Nationwide Health Information Network 3
(Date:5/28/2015)... -- Unilife Corporation ("Unilife" or "Company") (NASDAQ: UNIS, ASX: UNS), today ... will present at the Jefferies 2015 Global Healthcare Conference in ... on Monday, June 1, 2015. The conference ... listen only Webcast. To listen, please go to: http://ir.unilife.com/events.cfm ... for those unable to listen live. ...
(Date:5/28/2015)... MOUNTAIN VIEW, Calif. , May 28, 2015 ... healthcare informatics market, Frost & Sullivan recognizes ... Frost & Sullivan Award for Company of the ... effort to take HCM to the next level ... highly strategic acquisitions and followed them up with ...
(Date:5/28/2015)... 28, 2015  Freedom Meditech, Inc., a medical device ... from current blood-based standards to early and non-invasive detection, ... in a Series C financing. The company seeks to ... since founded. The company has also appointed Mr. ... member of the company,s board of directors. Mr. Gerace ...
Breaking Medicine Technology:Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 2Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 3Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 4Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 5Freedom Meditech Raises $4.8 Million and Appoints John Gerace as Chief Executive Officer 2Freedom Meditech Raises $4.8 Million and Appoints John Gerace as Chief Executive Officer 3Freedom Meditech Raises $4.8 Million and Appoints John Gerace as Chief Executive Officer 4
... LONDON and CRANBURY, N.J., Oct. 29 GlaxoSmithKline PLC ... today announced a definitive agreement to develop and commercialize ... for the treatment of Fabry disease, a rare inherited ... receive an exclusive worldwide license to develop, manufacture and ...
... Pharmaceuticals, Inc. (Nasdaq: AUXL) today announced that executive management will ... be held November 10-12, 2010 at the Arizona Biltmore Hotel ... scheduled to present an overview of the Company and its ... 2010. To listen to the audio web cast ...
Cached Medicine Technology:GSK and Amicus Therapeutics Enter Exclusive Worldwide Agreement to Develop and Commercialize Amigal™ for Fabry Disease 2GSK and Amicus Therapeutics Enter Exclusive Worldwide Agreement to Develop and Commercialize Amigal™ for Fabry Disease 3GSK and Amicus Therapeutics Enter Exclusive Worldwide Agreement to Develop and Commercialize Amigal™ for Fabry Disease 4GSK and Amicus Therapeutics Enter Exclusive Worldwide Agreement to Develop and Commercialize Amigal™ for Fabry Disease 5GSK and Amicus Therapeutics Enter Exclusive Worldwide Agreement to Develop and Commercialize Amigal™ for Fabry Disease 6Auxilium Pharmaceuticals to Present at the 2010 Annual Credit Suisse Healthcare Conference 2Auxilium Pharmaceuticals to Present at the 2010 Annual Credit Suisse Healthcare Conference 3
Cross action, round handle, maximum opening 2.8 mm....
Cross action, round handle, maximum opening 2.8 mm....
Small pupil irrigating nucleus chopper, wedge-shaped inferior edge with, blunt tip and front notch, for engaging the iris, 0.6 mm dual sideports, 20 gauge....
Nucleus chopper. For bimanual nucleus division....
Medicine Products: