Navigation Links
Impotence Drugs May Aid Brain Tumor Treatment
Date:5/12/2010

Levitra, Viagra allowed anti-cancer medication to more easily penetrate brain barrier, study found

WEDNESDAY, May 12 (HealthDay News) -- A drug already approved for the treatment of erectile dysfunction may actually help boost the effectiveness of treatments for brain tumors tied to both lung and breast cancer, research shows.

The finding stems from an animal study that indicated that leading erectile dysfunction medications sildenafil (Viagra) and vardenafil (Levitra) can enable the chemotherapy drug Herceptin to more easily penetrate the so-called blood-brain barrier that must be breached in order to successfully target cancer that has spread to the brain.

Although the blood-brain barrier is a naturally occurring mechanism designed to protect the brain from exposure to dangerous substances, in the case of cancer treatment it can significantly impede drug delivery, particularly of large-molecule drugs, such as Herceptin. However, erectile dysfunction drugs appear to increase the barrier's permeability.

"No matter how effective against cancer a chemotherapeutic agent may be, it can have little impact on brain tumors if it cannot cross the blood-brain tumor barrier," Dr. Keith Black, chairman of Cedars-Sinai's department of neurosurgery and director of the Maxine Dunitz Neurosurgical Institute in Los Angeles, said in a news release. "As we find new drugs that are able to target these tumor cells, it is imperative that we develop better ways to enable the medications to reach their targets."

The study team notes that about 220,000 Americans develop brain tumors each year as a result of cancers that begin elsewhere in the body. Lung cancer, they note, is the leading cause of cancer mortality in the United States, and about one-fifth of lung cancer cases end up spreading to the brain.

Work with mice demonstrated that initial Levitra exposure effectively doubled the amount of Herceptin that was able to reach brain tumors linked to lung and breast cancer.

What's more, when administering Herceptin and Levitra together, survival among the mice increased by 20 percent compared to treatment with just Herceptin alone.

The findings were published online recently in the journal PLoS One.

More Information

For more on brain tumors, visit the U.S. National Cancer Institute.



-- Alan Mozes



SOURCE: Cedars-Sinai Medical Center, news release, May 7, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Monitoring and control can limit side effects of promising cancer drugs
2. Parkinsons Drugs Tied to Compulsive Behaviors
3. Stomach Acid Drugs Come with Dangers, Studies Show
4. Anemia Drugs Hold Dangers for Kidney Patients
5. As FDA Eyes Prostate Cancer Drugs, Experts Urge Caution
6. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
7. OTC Drugs May Work Differently in Obese Kids
8. Study finds that drugs used for treatment of influenza in pregnancy appear to be safe
9. BATTLE links potential biomarkers to drugs for lung cancer
10. Matching Tumor Types to Drugs Boosts Lung Cancer Outcomes
11. Cholesterol Drugs May Slow MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
Breaking Medicine Technology: