Navigation Links
Impotence Drugs May Aid Brain Tumor Treatment
Date:5/12/2010

Levitra, Viagra allowed anti-cancer medication to more easily penetrate brain barrier, study found

WEDNESDAY, May 12 (HealthDay News) -- A drug already approved for the treatment of erectile dysfunction may actually help boost the effectiveness of treatments for brain tumors tied to both lung and breast cancer, research shows.

The finding stems from an animal study that indicated that leading erectile dysfunction medications sildenafil (Viagra) and vardenafil (Levitra) can enable the chemotherapy drug Herceptin to more easily penetrate the so-called blood-brain barrier that must be breached in order to successfully target cancer that has spread to the brain.

Although the blood-brain barrier is a naturally occurring mechanism designed to protect the brain from exposure to dangerous substances, in the case of cancer treatment it can significantly impede drug delivery, particularly of large-molecule drugs, such as Herceptin. However, erectile dysfunction drugs appear to increase the barrier's permeability.

"No matter how effective against cancer a chemotherapeutic agent may be, it can have little impact on brain tumors if it cannot cross the blood-brain tumor barrier," Dr. Keith Black, chairman of Cedars-Sinai's department of neurosurgery and director of the Maxine Dunitz Neurosurgical Institute in Los Angeles, said in a news release. "As we find new drugs that are able to target these tumor cells, it is imperative that we develop better ways to enable the medications to reach their targets."

The study team notes that about 220,000 Americans develop brain tumors each year as a result of cancers that begin elsewhere in the body. Lung cancer, they note, is the leading cause of cancer mortality in the United States, and about one-fifth of lung cancer cases end up spreading to the brain.

Work with mice demonstrated that initial Levitra exposure effectively doubled the amount of Herceptin that was able
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Monitoring and control can limit side effects of promising cancer drugs
2. Parkinsons Drugs Tied to Compulsive Behaviors
3. Stomach Acid Drugs Come with Dangers, Studies Show
4. Anemia Drugs Hold Dangers for Kidney Patients
5. As FDA Eyes Prostate Cancer Drugs, Experts Urge Caution
6. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
7. OTC Drugs May Work Differently in Obese Kids
8. Study finds that drugs used for treatment of influenza in pregnancy appear to be safe
9. BATTLE links potential biomarkers to drugs for lung cancer
10. Matching Tumor Types to Drugs Boosts Lung Cancer Outcomes
11. Cholesterol Drugs May Slow MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... Liver is the largest organ inside the ... the body in barring itself from poisons, helps in digestion ... also plays many important functions such as protein production, blood ... Many illnesses can affect the liver, an organ the size ... the right side of the abdomen, reducing its capabilities to ...
(Date:9/1/2014)... "Women struggle with weight gain typically associated ... as early as 15, if not earlier. Women ... and downs of hormone related weight gain. The ... seems to rage against the hidden and ever-present hormones ... 40's begin to face menopause and related changes, these ...
(Date:9/1/2014)... Spain Monday 1 September 2014: Permanent atrial fibrillation ... AF, according to research in more than 6 000 ... Vanassche from Belgium. The findings suggest that a simple ... doctors to better estimate stroke risk. , Ischaemic stroke ... accounting for over a million deaths and many more ...
(Date:9/1/2014)... York (PRWEB) September 01, 2014 ... retrieve, organize and analyze biological and genetic data. ... the activity of developing software tools to generate ... to be confused with biological computation. While bioinformatics ... understanding of biology can its related concepts, biological ...
(Date:9/1/2014)... September 01, 2014 Top10BestSEOHosting.com has ... many web host suppliers carefully, Top10BestSEOHosting.com is here ... the best web hosting suppliers in 2014. , ... clients with a top-of-the-line shared hosting plan. The ... easy-to-use platform that is affordable, accessible and powerful ...
Breaking Medicine News(10 mins):Health News:Global Liver Diseases and Therapies Market- The Key Basics by Transparency Market Research 2Health News:Global Liver Diseases and Therapies Market- The Key Basics by Transparency Market Research 3Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 2Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 3Health News:Permanent AF doubles risk of stroke compared to paroxysmal AF 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 3Health News:Bioinformatics Market: A fusion of Computers and Biological Data 4Health News:Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers 2
... , MONDAY, Oct. 3 (HealthDay News) -- Even ... as depression, vision problems and difficulty thinking, according to a ... Canadian Stroke Congress in Ottawa, suggest new guidelines are needed ... said. "There is no such thing as a mild ...
... MDA recent study accepted for publication in Molecular Endocrinology, ... exposure to environmentally relevant doses of bisphenol A (BPA) ... that may increase the propensity to develop cancer. ... specific industrial purposes, is detected in body fluids of ...
... Not only are smokers twice as likely to have strokes, ... have them, according to a study presented today at the ... researchers studied 982 stroke patients (264 smokers and 718 non-smokers) ... of stroke patients who smoked was 58, compared to age ...
... is common among patients with gout. According to the ... peer-reviewed journal of the American College of Rheumatology (ACR), ... foot-related pain, impairment and disability. Gout patients also reported ... important factors for selecting footwear. Gout is a ...
... South Africa and Brazil become happier as they age. New ... developing country can significantly improve the wellbeing of its older ... people in South Africa and Brazil improved between 2002 and ... social policies, according to a study from the New Dynamics ...
... Oct. 2 (HealthDay News) --,Children can enjoy some Halloween candy ... Mitchell, a Chicago dentist. Mitchell said the key to ... of candy children eat, but also how long the sugar ... possible after eating candy may keep harmful bacteria from developing, ...
Cached Medicine News:Health News:Mild Strokes May Have Hidden Effects 2Health News:BPA exposure in utero may increase predisposition to breast cancer 2Health News:Smoking causes stroke to occur 2Health News:Poor footwear linked to foot impairment and disability in gout patients 2Health News:Older people are happier in Brazil and South Africa 2
(Date:8/29/2014)... , Aug. 29, 2014 Thoratec Corporation ... device-based mechanical circulatory support therapies to save, support and ... in the 2014 Morgan Stanley Global Healthcare Conference on ... , President and Chief Executive Officer, will provide an ... Daylight Time (9:55 a.m., Pacific Daylight Time).   ...
(Date:8/29/2014)... 29, 2014 Research and Markets  has announced ... Insight 2014" report to their offering. ... one of the largest segments of pharmaceuticals industry. The numbers ... the available therapies were unable to meet the market requirements. ... for CNS disorder, especially over the past two decades. The ...
(Date:8/29/2014)... SILVER SPRING, Md. , Aug. 29, 2014 /PRNewswire/ ... today that the U.S. District Court for the District ... in its favor in the company,s case against Sandoz, ... opinion, Judge Peter Sheridan ruled that U.S. ... Sandoz, Inc., and enjoined Sandoz from marketing its generic ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2District Court Decision Received In Remodulin Patent Case 2
... Oswego, Oregon based ThermoGear, Inc., partnered with DVM Solutions, ... new high technology veterinary surgical system that took place ... Florida.  The Chillbuster®VET Surgical Blanket and Cage Mat are ... Veterinarians who have been testing the system. ...
... Corporation (NYSE: BSX ) today announced the ... which is designed to assess the safety and performance ... single-blind, non-inferiority trial will compare the SYNERGY Stent to ... a single de novo native coronary artery ...
Cached Medicine Technology:High Tech Vet Medical Warming System Introduced at Orlando 2High Tech Vet Medical Warming System Introduced at Orlando 3Boston Scientific Completes Enrollment in EVOLVE Clinical Trial to Evaluate SYNERGY™ Drug-Eluting Coronary Stent 2Boston Scientific Completes Enrollment in EVOLVE Clinical Trial to Evaluate SYNERGY™ Drug-Eluting Coronary Stent 3Boston Scientific Completes Enrollment in EVOLVE Clinical Trial to Evaluate SYNERGY™ Drug-Eluting Coronary Stent 4
Keeler Professional Combi Retinoscope with new slimline handle and lithium or dry cell option....
System, English (Continental cord), 230 VAC....
300XL System, English (U.K. cord), 100-240 VAC....
Micro-mini fiber optic light....
Medicine Products: