Navigation Links
Implanted Microchip Might Be Future of Drug Delivery

By Maureen Salamon
HealthDay Reporter

THURSDAY, Feb. 16 (HealthDay News) -- Remote controls may not be for just appliances anymore. In a new small study, women with severe osteoporosis were implanted with a microchip that releases bone-building drugs at the push of a button, a delivery method that could someday become common for various health conditions.

Roughly 1.5-by-2.5 inches in size, the microchip significantly improved patient compliance with a drug regimen that normally requires painful daily self-injections, study authors said. The clinical trial, conducted on seven osteoporosis patients in Denmark, was the first to test a wirelessly controlled microchip in this capacity.

"It frees patients from the burden of managing their disease on a daily basis," said Robert Farra, co-author of the study and president and chief operating officer of MicroCHIPS Inc., the Waltham, Mass., company that funded and supervised the trial. "I think there will be a class of drugs [for other conditions] that will be very suitable to use the chip for . . . we were very pleased with the results."

The study is published Feb. 16 in the journal Science Translational Medicine, coinciding with its presentation at the American Association for the Advancement of Science annual meeting in Vancouver, Canada.

Along with researchers from MIT, Harvard Medical School and other companies and institutions, Farra implanted the microchip just under the skin near the waistline of the seven women, who ranged from ages 65 to 70 and had been using pre-filled injection pens containing teriparatide (brand name Forteo) for their severe osteoporosis, a bone-thinning disease.

Although a fibrous membrane grew around the device, which was expected, the microchip delivered the drug as effectively as daily injections, the study said. Blood tests done after the 12-month study period indicated rates of bone formation similar to when the women self-injected the drug.

Because daily injections can be psychologically and physically challenging, Farra said, only 25 percent of patients on teriparatide actually finish a typical 24-month regimen. But with the implant -- which delivered 20 timed doses controlled by doctors -- the compliance rate rose to 100 percent.

About 50,000 Americans take the drug each year at a cost of $10,000 to $12,000, which would be comparable to the cost of the microchip and the minor surgery to embed it, he said. The microchip can be implanted under local anesthesia in a doctor's office.

"It not only should offer a better quality of life, we should see improved outcomes because of the compliance boost," Farra said, adding that his company is developing a model that will deliver a year's worth of doses. He said he hopes it is approved by the U.S. Food and Drug Administration and on the market within four years.

Dr. Robert Recker, director of the Osteoporosis Research Center at Creighton University in Omaha, Neb., said he was skeptical that the microchip could keep the Forteo stable at body temperature since the drug is normally refrigerated when contained in injection pens.

However, Farra said that researchers had modified the drug to make this possible, an effort made easier because each dose was also sealed in tiny air- and moisture-proof compartments in the microchip.

The reservoirs pop open on a pre-programmed schedule or via a wireless signal, which can be sent from a doctor's computer or smartphone, Farra said.

"I do not see how this can be done with [a] reservoir, either above or below the skin surface," Recker said. "I think the claim must be corroborated with more studies. They must explain how they preserve the drug at body temperature."

More information

The University of New Hampshire has more about human microchip implantation.

SOURCES: Robert Farra, president and chief operating officer, MicroCHIPS Inc., Waltham, Mass.; Robert R. Recker, M.D., professor of medicine, and director, Osteoporosis Research Center, Creighton University, Omaha, Neb; Feb. 16, 2012, Science Translational Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cell Transplantation study shows bone growth from implanted tooth and dental pulp stem cells
2. Combination therapy rids common infection from implanted medical devices
3. Wireless power could cut cord for patients with implanted heart pumps
4. Penn study sheds light on end of life management of implanted defibrillators
5. Implanted Heart Devices Have Real-World Benefits: Study
6. As End of Life Nears, What to Do With Implanted Defibrillators?
7. New Implanted Defibrillator May Be Simpler, Safer
8. In Tests, Implanted Monitor Detects Atrial Fibrillation
9. Magnetic attraction: NIST/CU microchip demonstrates concept of MRAM for biomolecules
10. Microchip Spots Cancerous Tumors Within an Hour, Study Shows
11. Arsenic Might Be Found in Some Organic Foods: Study
Post Your Comments:
Related Image:
Implanted Microchip Might Be Future of Drug Delivery
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin ... companies that call for a minimum wage raise to $12 an hour by 2020 and ... This will restore the lost value of the minimum wage, assure the wage floor does ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
(Date:6/24/2016)... ... 24, 2016 , ... National recruitment firm Slone Partners is pleased ... and genomics experience, as Vice President of North American Capital Sales at HTG ... leading the sales team in the commercialization of the HTG EdgeSeq system and associated ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: