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Implantable monitor may help in managing diastolic heart failure
Date:12/11/2008

Philadelphia, 11 December 2008 An implantable hemodynamic monitor (IHM) may help to guide medical treatment in a large subgroup of patients with heart failurethose with diastolic heart failure (DHF), reports a study in the December Journal of Cardiac Failure (http://www.onlinejcf.com/), published by Elsevier.

Led by Michael R. Zile, M.D., of Medical University of South Carolina, Charleston, the researchers analyzed data on DHF patients enrolled in a larger randomized trial evaluating the IHM for heart failure. The IHM is a surgically implanted device that continuously records data on heart function and other key variables. The data can then be downloaded for analysis by health care professionals, who can use it to make adjustments in medical therapy. The goal is to avoid sudden drops in heart function, called acute decompensation.

The main "COMPASS-HF" study included 274 patients with all types of heart failure. The original results showed that the risk of heart failure events was reduced by about 20 percent in patients treated with the IHM, although the difference was not statistically significant.

The new analysis focused on the subgroup of patients with DHF. In DHF, the heart still has normal pumping function (ejection fraction), but no longer relaxes sufficiently to fill with blood normally. In the COMPASS-HF study, 70 patients with DHF were randomly assigned to receive the IHM, while the rest were managed without the IHM.

As in the main study, DHF patients who received the IHM device had a 20 percent reduction in heart failure events, although the difference was not significant. A 29 percent reduction in the risk of hospitalization for heart failure was also nonsignificant.

The IHM did lead to some significant changes in patient management, including more frequent adjustments in the dose of diureticsa key part of treatment for heart failure. As in the large
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Contact: Maureen Hunter
m.hunter@elsevier.com
215-239-3671
Elsevier
Source:Eurekalert

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