Navigation Links
Implantable device designed to detect, stop seizures under study at MCG
Date:9/10/2007

A small device implanted in the skull that detects oncoming seizures, then delivers a brief electrical stimulus to the brain to stop them is under study at the Medical College of Georgia.

MCG is among 28 U.S. centers participating in a study to determine if the neurostimulator device can help patients whose seizures are not well controlled by drugs.

The device constantly monitors electrical activity of the brain, gets accustomed to what is normal for that patient and, when it detects activity that is abnormal, within a few milliseconds, sends out a small electrical stimulus to stop it, says Dr. Yong Park, MCG pediatric epileptologist and a principal investigator.

At MCG Medical Center, the RNS System, developed by California-based medical device manufacturer NeuroPace, will be used in about 10 patients age 18-70 who have failed to get their seizures controlled with at least two medications. About 240 patients are expected to enroll nationwide.

Eligible participants must have at least three seizures per month and no more than two seizure foci in the brain. Seizure activity is closely monitored through a diary and monthly doctor visits for three months before patients become eligible.

Participants have a device implanted in the skull, with up to two wires containing electrodes placed near the seizure focus. A modified laptop computer looks at electrical activity picked up by the neurostimulator, then is used to program the device to recognize a patients seizure activity. Physicians can continue to fine-tune the detection and stimulation patterns.

During the first month after implant, the RNS is set for detection only while doctors design a set of parameters that allow it to reliably detect the onset of seizure activity, says Dr. Patty Ray, study coordinator. After one month, half of the patients are set for detection and responsive stimulation, the other half continue with detection only. After four months, all devices are set for detection and responsive stimulation throughout the remainder of the two-year study. After the study, patients will be eligible for a study to continue to use the device until it receives FDA approval, Dr. Ray says.

Participants remain on anti-seizure medication throughout the study, although Dr. Park suspects some patients may eventually be weaned off drugs. During this study, researchers also are collecting data on which drugs work best with the neurostimulator.

MCG participated in a smaller feasibility study of the neurostimulator in 2004 and prior to that was among the first centers in the country to use it as an external, temporary measure to try to stop seizures in hospitalized patients whose seizure activity was being monitored, Dr. Park says.

About 1 in 200 people have seizures and about 1 out of 3 cannot get seizures under control with one or more medications. Some people are not candidates for traditional epilepsy surgery to remove the seizure focus because the location increases the risk of problems or deficits, because there are too many foci or because they simply do not want the surgery, Dr. Park says. Early evidence indicates the RNS device might be most effective for foci in the medial temporal lobe, an area deep inside the brain involved in memory, where surgery is not an option, he says.

A handful of new drugs, with generally fewer side effects, also have become available in the last few years, giving patients and their doctors more options, he says. MCG has begun studies of three additional anti-seizure medications.

Also on the horizon is a mechanism that delivers a bolus of drug directly to the seizure focus in the brain, which may enhance efficacy and decrease side effects, as well as gene therapy to modify abnormal brain tissue, says Dr. Park, who wants MCG to participate when those studies move to clinical trials.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

Related medicine news :

1. Implantable Contact Lens Found Safe and Effective
2. New Implantable Device That Can Keep The Heart Ticking
3. Making MRIs Safe for Patients With Implantable Heart Devices
4. Implantable devices to be powered by organosilicon compounds in the future
5. New Implantable Cardioverter Defibrillators to avoid unnecessary shocks
6. Combination therapy for patients treated with Implantable Cardioverter Defibrillator
7. First Implantable artificial heart gets FDA’s approva
8. Use of Implantable Cardioverter Defibrillators Canada Lags Behind U.S
9. Alerts for safety of heart device
10. FDA approves new device to treat womens bleeding disorder
11. A new hearing device improves hearing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... for Global Policy Solutions is vehemently opposed to Donald Trump’s budget, “A New ... for despair that inspires fear, demonizes the poor, marginalizes underserved populations, undermines productivity, ...
(Date:5/24/2017)... ... ... Medic CE , a Career Step company, is sponsoring a live, 1-hour ... Journal of Emergency Medical Services (JEMS). The free webinar, to be held on Wednesday, ... Duckworth, LP, a career fire captain as well as founder and director of the ...
(Date:5/24/2017)... , ... May 24, 2017 , ... Rob Lowe is ... “Informed,” developed for Public Television. “Informed” brings the public important topics from all aspects ... treatment of the feet and issues surrounding feet and ankles. , Podiatry is essential ...
(Date:5/24/2017)... ... 24, 2017 , ... Dymedix® Diagnostics, Inc., the ... it had completed the first phase of building a global distribution network. To ... world (ROW) authorized dealers specializing in polysomnography accessories. The company plans to ...
(Date:5/23/2017)... ... May 23, 2017 , ... PM360, the premier information resource ... the winners of its 3rd Annual ELITE Awards. The ELITE (Exceptional • Leaders ... healthcare industry today. , Out of more than 500 submissions, 100 winners were ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... May 9, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, today announced it has earned a spot on ... list. The Company was ranked among 500 U.S. employers ... and Healthcare Equipment and Services. The annual ... an anonymous, independent survey of over 30,000 employees across ...
(Date:5/8/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO)., has completed its ... health care service center company based in ... relationship management programs for leading pharmaceutical manufacturers and health ... WRB will join Envoy Health Management, LLC , ... biotech firms, and other service companies. Together, WRB and ...
(Date:5/4/2017)...  A recent study published in the American ... as a means of disinfection anesthesia workstations ... on anesthesia workstations. In the study, UVC disinfection ... equipment surfaces contaminated with three (3) organisms commonly ... further validates the body of literature supporting Tru-D," ...
Breaking Medicine Technology: