Navigation Links
Impaired fat-burning gene worsens diabetes
Date:2/7/2008

Researchers at the Swedish medical university Karolinska Institutet have in collaboration with researchers from Finland, China, Japan and the US discovered new cellular mechanisms that lead to in insulin resistance in people with diabetes. The results are published in the scientific journal Cell.

Type 2-diabetes is a chronic disease resulting from a reduction in insulin-production from the pancreas or an inability of other tissues in the body to respond adequately to the produced insulin, so called insulin resistance. This leads to increased blood sugar, which in turn leads to a worsening of the insulin resistance, increasing the risk of developing many serious diabetes-associated complications.

An international research team, led by Professor Juleen R. Zierath at Karolinska Institutet in Stockholm have identified previously unknown molecular mechanisms by which elevated blood sugar leads to impaired insulin sensitivity in people with diabetes. The research team identified a fat-burning gene, the products of which are required to maintain the cells insulin sensitivity. They also discovered that this gene is reduced in muscle tissue from people with high blood sugar and type 2-diabetes. In the absence of the enzyme that is made by this gene, muscles have reduced insulin sensitivity, impaired fat burning ability, which leads to an increased risk of developing obesity.

The expression of this gene is reduced when blood sugar rises, but activity can be restored if blood sugar is controlled by pharmacological treatment or exercise, says Professor Juleen Zierath. Our results underscore the importance of tight regulation of blood sugar for people with diabetes.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-482-893
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Technique enhances digital television viewing for visually-impaired
2. NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired
3. Rhode Island Hospital to study driving ability of cognitively impaired elders
4. The Eyes of Christmas: Top Stars Telecast 12 Hours of Holiday Music and Memories for the Visually Impaired to Over 80 Million Homes on Multiple Cable Networks
5. Computer simulator allows visually-impaired to drive
6. Secondhand Smoke Worsens Lung Function in Cystic Fibrosis Patients
7. Smoking Worsens Prognosis for IPF Patients
8. Kaiser Permanente -- Group Health study shows depression worsens HIV treatment
9. New research shows how chronic stress worsens neurodegenerative disease course
10. Low-Carb Diets Better Than Low-Fat Diets at Preventing Diabetes
11. Team-based approach improves diabetes care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... 2017 , ... Orbita, Inc., a leading provider ... Healthwise ® at HIMSS 2017 to showcase a breakthrough in remote ... technology and services, will demonstrate a voice-powered knowedge assistant based on Orbita ...
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter ... Show on the Pet Life Radio network. The episode, which was posted this ... topics including: what factors led to Park Cities Pet Sitter’s being awarded the 2017 ...
(Date:2/17/2017)... ... February 17, 2017 , ... The ... systems change designed to further positively impact the health and wellness of our ... long considered it our duty to seriously consider releasing our assets beyond our ...
(Date:2/17/2017)... VA (PRWEB) , ... February 17, 2017 , ... ... the Steps to Prevent a Warning Letter, **An FDAnews Webinar**, Feb. 23, 2017 ... , Do manufacturers distinguish between corrective action (CA) and preventive action (PA)? , ...
(Date:2/17/2017)... ... February 17, 2017 , ... Pharmica Consulting attended ... all facets of clinical trial planning and management. Pharmica discussed the importance of ... In addition, attendees stopping by Pharmica’s booth were able to demo its cloud-based ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... and Markets has announced the addition of the "Drug-Eluting Stents - ... ... US, Canada , Japan , ... America , and Rest of World. Annual estimates and forecasts are ... is provided for these markets. Market data and analytics are derived from ...
(Date:2/17/2017)... -- In partnership with CitiHope , Panexus Haiti ... The Jack Brewer Foundation (JBF Worldwide) has sent ... of medicine to Innovating Health International (IHI) ... dedicated to treating chronic diseases and addressing women,s health issues in ... Haiti and providing these medicines to the ...
(Date:2/17/2017)... 17, 2017  Featuring new and ... the  2017 HIMSS Conference & Exhibition (HIMSS17 ),  Royal ... global leader in health technology,  will ... population health management, acute healthcare informatics ... a highly secure, cloud-based ecosystem. Visitors ...
Breaking Medicine Technology: