Navigation Links
Impaired fat-burning gene worsens diabetes
Date:2/7/2008

Researchers at the Swedish medical university Karolinska Institutet have in collaboration with researchers from Finland, China, Japan and the US discovered new cellular mechanisms that lead to in insulin resistance in people with diabetes. The results are published in the scientific journal Cell.

Type 2-diabetes is a chronic disease resulting from a reduction in insulin-production from the pancreas or an inability of other tissues in the body to respond adequately to the produced insulin, so called insulin resistance. This leads to increased blood sugar, which in turn leads to a worsening of the insulin resistance, increasing the risk of developing many serious diabetes-associated complications.

An international research team, led by Professor Juleen R. Zierath at Karolinska Institutet in Stockholm have identified previously unknown molecular mechanisms by which elevated blood sugar leads to impaired insulin sensitivity in people with diabetes. The research team identified a fat-burning gene, the products of which are required to maintain the cells insulin sensitivity. They also discovered that this gene is reduced in muscle tissue from people with high blood sugar and type 2-diabetes. In the absence of the enzyme that is made by this gene, muscles have reduced insulin sensitivity, impaired fat burning ability, which leads to an increased risk of developing obesity.

The expression of this gene is reduced when blood sugar rises, but activity can be restored if blood sugar is controlled by pharmacological treatment or exercise, says Professor Juleen Zierath. Our results underscore the importance of tight regulation of blood sugar for people with diabetes.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-482-893
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Technique enhances digital television viewing for visually-impaired
2. NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired
3. Rhode Island Hospital to study driving ability of cognitively impaired elders
4. The Eyes of Christmas: Top Stars Telecast 12 Hours of Holiday Music and Memories for the Visually Impaired to Over 80 Million Homes on Multiple Cable Networks
5. Computer simulator allows visually-impaired to drive
6. Secondhand Smoke Worsens Lung Function in Cystic Fibrosis Patients
7. Smoking Worsens Prognosis for IPF Patients
8. Kaiser Permanente -- Group Health study shows depression worsens HIV treatment
9. New research shows how chronic stress worsens neurodegenerative disease course
10. Low-Carb Diets Better Than Low-Fat Diets at Preventing Diabetes
11. Team-based approach improves diabetes care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... Serenity Recovery, ... another video highlighting one of the many supplemental program options offered at their ... a 5 th Degree Black Belt in the Shorin-ryu style of Karate that ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Horizon Foundation for ... pilot initiative to improve oral health-related awareness, education, prevention and treatment for young ... providers and promote best practices in 10 New Jersey counties where dental health ...
(Date:5/25/2016)... ... 2016 , ... New studies published today by the ... states. The outcomes examined in these studies include recovery of physical health and ... medical care. , “The goal of the studies is to provide information about ...
(Date:5/25/2016)... ... May 25, 2016 , ... Cheryl Bowker of Bowker ... bestow: the Dick McKenna Good Hands Legacy Award. McKenna ran one of Allstate’s most ... continues to inspire all those who knew him. The award named for him is ...
(Date:5/25/2016)... ... ... Casa Velas, an adults-only boutique hotel in Puerto Vallarta, Mexico, introduces a ... wellness suites . The two 1,350 sq. ft. suites which debuted in late 2015 ... amenities, from a custom soap selection and in-suite exercise kit to a personal wellness ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... May 23, 2016 According ... Share, Development, Growth and Demand Forecast to 2022 ... Other), by Application (Drug Discovery and Development, Proteomics, ... (Pharmaceuticals, Life Science and Biotechnology, Academic and Research ... Research, the global mass spectrometry market ...
(Date:5/23/2016)... -- The World Health Organization (WHO) expanded the Intended Use ... aged 13 years, and above. Effective immediately, the PrePex device, ... adolescent males in the 14 priority countries in Southern and ... male circumcision device to receive WHO Prequalification on 31 May ... said: " The expanded use of PrePex for ...
(Date:5/23/2016)... UAE, May 23, 2016 Experts ... of Precision Medicine and the role of technology ...   The First International Conference of VPS-Penn Medicine ... distinguished patronage and presence of Sheikh Nahyan bin Mubarak Al ... in Precision Medicine, which helps provide personalized medicine and tailor-made ...
Breaking Medicine Technology: