Navigation Links
Impaired fat-burning gene worsens diabetes
Date:2/7/2008

Researchers at the Swedish medical university Karolinska Institutet have in collaboration with researchers from Finland, China, Japan and the US discovered new cellular mechanisms that lead to in insulin resistance in people with diabetes. The results are published in the scientific journal Cell.

Type 2-diabetes is a chronic disease resulting from a reduction in insulin-production from the pancreas or an inability of other tissues in the body to respond adequately to the produced insulin, so called insulin resistance. This leads to increased blood sugar, which in turn leads to a worsening of the insulin resistance, increasing the risk of developing many serious diabetes-associated complications.

An international research team, led by Professor Juleen R. Zierath at Karolinska Institutet in Stockholm have identified previously unknown molecular mechanisms by which elevated blood sugar leads to impaired insulin sensitivity in people with diabetes. The research team identified a fat-burning gene, the products of which are required to maintain the cells insulin sensitivity. They also discovered that this gene is reduced in muscle tissue from people with high blood sugar and type 2-diabetes. In the absence of the enzyme that is made by this gene, muscles have reduced insulin sensitivity, impaired fat burning ability, which leads to an increased risk of developing obesity.

The expression of this gene is reduced when blood sugar rises, but activity can be restored if blood sugar is controlled by pharmacological treatment or exercise, says Professor Juleen Zierath. Our results underscore the importance of tight regulation of blood sugar for people with diabetes.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-482-893
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Technique enhances digital television viewing for visually-impaired
2. NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired
3. Rhode Island Hospital to study driving ability of cognitively impaired elders
4. The Eyes of Christmas: Top Stars Telecast 12 Hours of Holiday Music and Memories for the Visually Impaired to Over 80 Million Homes on Multiple Cable Networks
5. Computer simulator allows visually-impaired to drive
6. Secondhand Smoke Worsens Lung Function in Cystic Fibrosis Patients
7. Smoking Worsens Prognosis for IPF Patients
8. Kaiser Permanente -- Group Health study shows depression worsens HIV treatment
9. New research shows how chronic stress worsens neurodegenerative disease course
10. Low-Carb Diets Better Than Low-Fat Diets at Preventing Diabetes
11. Team-based approach improves diabetes care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... ... From a health perspective, 2017 will clearly be the Year of the Gut. ... health and general physical well-being. The New York Times suggested a “ Gut Makeover ... Charlottesville restaurant, good gut health is clearly on the menu. Threepenny Cafe ...
(Date:1/18/2017)... ... January 18, 2017 , ... The ... Bioengineering are collaborating on a research project focused on multiple sclerosis (MS). Led ... to use nanotechnology to control the disease without compromising normal immune function that ...
(Date:1/18/2017)... NJ (PRWEB) , ... January ... ... the specialty pharmacy industry’s leading journal and most-read publication among specialty pharmacists ... University Medical Center through its Strategic Alliance Partnership (SAP) program, announced Brian ...
(Date:1/18/2017)... Beach, FL (PRWEB) , ... January 18, 2017 , ... ... a fund raiser for Smile Train, an international charity that provides free surgery to ... hobby of mine and in the past I have run to support the efforts ...
(Date:1/18/2017)... ... January 18, 2017 , ... The Portee Insurance Agency, a family managed firm ... central Maryland and the DC region, is inaugurating a charity event aimed at fighting ... year, making it the #1 killer in America. However, heart disease is largely preventable, ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... RATON, Fla. , Jan. 19, 2017 /PRNewswire/ ... a medical device company specializing in the treatment ... such as keloids, with superficial radiation therapy, today ... and full year 2016 financial results on Thursday, February ... The Company will hold a conference call with ...
(Date:1/19/2017)... CAMBRIDGE, England , January 19, 2017 ... MedImmune and Otsuka in the Milner Therapeutics Consortium   ... academic scientists in Cambridge   ... Inc. (NYSE: PFE ) as a partner ... join the Consortium, which enables the efficient transfer of ...
(Date:1/19/2017)... , January 18, 2017 , , Marks E-QURE ... distribution agreement, following similar agreements in ... Wound care is $2 5 ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment ... - Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia for ...
Breaking Medicine Technology: