Navigation Links
Impaired blood vessel function found in cystic fibrosis patients
Date:11/26/2012

AUGUSTA, Ga. The first evidence of blood vessel dysfunction has been found in a small cohort of generally healthy young people with cystic fibrosis, researchers report.

"Even though the lung function in these kids is fine at this point, there is evidence of vascular dysfunction and exercise intolerance," said Dr. Ryan A. Harris, clinical exercise physiologist at the Medical College of Georgia and Institute of Public and Preventive Health at Georgia Health Sciences University. "We think this blood vessel dysfunction could be contributing to their exercise intolerance, which is an independent predictor of mortality in these kids irrespective of their lung function."

The findings raise questions about whether dysfunctional arteries affect patients' ability to exercise, which is already recommended to help combat the disease's hallmark lung complications, and whether exercise can also improve blood vessel function and potentially help forestall cardiovascular disease.

Although their blood pressures tend to be normal and there is no established risk, cystic fibrosis patients have only recently lived long enough to acquire even an accelerated version of cardiovascular disease, said Dr. Katie T. McKie, Director of the Pediatric Cystic Fibrosis Center at the GHS Children's Medical Center. The median predicted age of survival is the mid-30s and nearly half the patients in the United States are over age 18, according to the Cystic Fibrosis Foundation. Fifteen years ago, survival rates for the genetic disease were about half that, McKie said.

The blood vessel or endothelial dysfunction Harris and McKie found in these patients is essentially the reduced ability of blood vessels to respond to important cues, such as dilating when exercise or stress increase the body's demand for blood and oxygen. The dysfunction may be linked to chronic inflammation and oxidative stress which, in turn, impair the body's ability to use nitric oxide, a major blood vessel dilator, said Harris, corresponding author of the study in CHEST Journal.

Despite major advances in treatment and survival, cystic fibrosis patients tend to live with a chronic, low-grade inflammation resulting from a chronic state of infection. The genetic mutation that disrupts the body's balance of salt and fluid thickens lung mucus, which traps inhaled bacteria and viruses that are normally cleared.

"They are in a low-grade stage of inflammation all the time," Harris said. Patient participants in the study, for example, had a higher rate of inflammation than healthy controls and the higher their concentrations of inflammatory drivers such as C-reactive protein, the lower their pulmonary function.

When the 15 patients, age 8-18, peddled a stationary bike as long and hard as they could, it was leg fatigue rather than lung limitations, which stopped them. "It's not their lungs that are limiting their exercise capacity," Harris said. "But what about non-pulmonary factors that we had no idea existed in these kids?"

"At this stage, their lungs are as healthy as those of their healthy counterparts," McKie added.

They found that even though the patients could take in oxygen well they were not as good as their 15 healthy counterparts at using it. At rest, oxygen saturation in the patients' blood was lower. During peak exercise, the amount of oxygen they consumed was 14 percent lower while expelled air had higher oxygen levels, indicating that their muscles were not as efficient at using it.

Another telltale sign was the fact that their blood vessels simply didn't dilate as well. The researchers put a cuff on the lower arm to increase blood flow through the brachial artery, a major vessel in the bicep. How much the artery dilates in response to the increased flow when the cuff is released depends on how much nitric oxide is available and it was significantly less in patients versus controls.

Future studies are needed to determine exactly why cystic fibrosis patients appear to have less nitric oxide available and whether improving lung function and exercise capacity can improve the vascular health of patients of all ages.

MCG researchers already are doing a small pilot study giving over-the-counter antioxidants to combat oxidative stress, enhance nitric oxide availability and improve blood-vessel dilation. "If we can help improve vascular function, we can hopefully improve their ability to deliver oxygen and increase their exercise capacity," Harris said.

Maintaining good lung function typically requires multiple medications and several hours of daily therapy to break up the mucus, said McKie, a study co-author. She also encourages patients to live full, active lives. "We tell them they are going to live a full life, get married, be president, play baseball, whatever they want to do, it just takes a little extra work." Patient study participants included a swimmer, basketball, baseball and softball players. Guidelines for routine exercise testing of cystic fibrosis should be published early next year.

About 30,000 Americans have cystic fibrosis and 10 million more are carriers of the defective gene, according to the Cystic Fibrosis Foundation. Endothelial dysfunction has been found in older individuals with chronic medical problems such as chronic obstructive pulmonary disease, diabetes and obesity.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Migraine-associated brain changes not related to impaired cognition
2. Hearing impaired ears hear differently in noisy environments
3. Obesity and metabolic syndrome associated with impaired brain function in adolescents
4. UC students design a better pill bottle for the blind and visually impaired
5. Pathway identified in human lymphoma points way to new blood cancer treatments
6. Genetic factor holds key to blood vessel health
7. Exercise benefits found for pregnancies with high blood pressure
8. Human umbilical cord blood cell co-culture supports embryonic stem cell expansion
9. G proteins regulate remodelling of blood vessels
10. No Need to Fast Before Cholesterol Blood Test: Study
11. Drinking green tea with starchy food may help lower blood sugar spikes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Impaired blood vessel function found in cystic fibrosis patients
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
Breaking Medicine Technology: