Navigation Links
Impact of elevated homocysteine levels on vision under study
Date:10/15/2007

Homocysteine, an amino acid believed to contribute to heart attack, stroke and dementia, likely also is a player in retinal damage and vision loss, researchers say.

Homocysteine levels rise when folic acid levels drop, a common problem for Americans whose diets are often poor in folate-rich fruits, tomatoes, vegetables and grains, according to Dr. Sylvia Smith, cell biologist at the Medical College of Georgia.

Scientists want to know the impact of resulting elevated homocysteine levels on the extensive blood vessel and neuronal network of the retina; their preliminary evidence suggests that it isnt good.

You dont have to be a cell biologist to see that there is a problem in this retina. Its terribly disrupted, Dr. Smith says, looking at images of a fragmented 10-layer retina exposed to high levels of homocysteine. A healthy retina tissue at the back of the eye that receives light and transforms it to a neural impulse that goes to the brain is beautifully organized, horizontally and vertically, she says.

What is the consequence of slightly elevated homocysteine on the retina, on its architecture, its functioning, its ability to withstand stress? Dr. Smith hopes to find the answers with a $1.8 million grant from the National Institutes of Health.

She and Dr. Vadivel Ganapathy, chair of the MCG Department of Biochemistry and Molecular Biology, have been studying how folate gets to the retina and how diseases such as diabetes interfere. They found it hard to ignore homocysteine as they studied folate, a vitamin essential to life.

Folate and vitamin B12 which Americans typically get plenty of convert homocysteine to methionine, an amino acid essential to protein synthesis.

Without the conversion, rising homocysteine levels interfere with the folding and structure of collagen, a component of bone, tissue and the basement membrane of blood vessel walls. When pregnant women dont get enough folate, the result can be devastating neural tube defects, such as spina bifida, in their babies. People with a genetic defect that results in a homocysteine level 40 times the norm are tall, thin, have osteoporosis and a markedly increased risk of clotting, Dr. Ganapathy says. Tiny clots cause small, frequent strokes, cumulative tissue damage and, eventually, mental retardation. If you are having thrombotic attacks in the retina like what happens in the brain, it will affect visual function, too he says. Excess homocysteine is even bad for the folate transporter protein, the researchers have shown.

They are studying a mouse model with a slightly elevated homocysteine level that simulates a low-folate diet in humans; a version of the mouse that also has diabetes, which goes hand-in-hand with cardiovascular disease and retinopathy; and a second model of the rare genetic defect that results in extraordinarily high homocysteine levels.

They will follow the mice over their lifetime, putting them on diets that elevate and lower folate levels, measuring resultant homocysteine levels and the impact on the retina. Next year, they will test the animals vision in conjunction with the Cleveland Clinic.

They hypothesize that sustained elevation will compromise retinal function and degrade the once well-stratified tissue. They have shown in pilot studies that adding diabetes to the mix makes bad matters worse.

At any point in your life, too much homocysteine can be problematic, whether you are talking about pregnant women, cardiovascular disease or dementia, says Dr. Smith. If homocysteine is not converted into methionine or cysteine (by vitamin B6) to aid protein synthesis, it can do something bad.

Dr. Ganapathy notes that people need only about 1 microgram per day of vitamin B12, which comes from microorganisms common in animals gastrointestinal tract. Strict vegetarians are typically the only Americans who have problems with B12 deficiency, he says. People need about 400 micrograms of folate daily. Pregnant women as well as those trying to become pregnant need at least double that.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

Related medicine news :

1. Double impact vaccine
2. Breastfeeding not found to have an impact on weight of the child.
3. Environmental Factors Found To Have An Impact On The Sex of A Child
4. Sex timing has no impact on risk of Birth defects
5. Impact on Lung function based on exposure
6. Personality Impacts Arthritis
7. SARS impact could be devastating
8. Marriage does not have much impact on life satisfaction
9. Support Services found to Dramatically Impact Pediatric Health Care
10. The Impact of Stress Early In Life
11. Environmental Factors Found To Have An Impact On The Sex of A Child
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 2017 , ... Z-Medica, LLC, a leading developer and marketer ... will acquire QuikClot® Bleeding Control Kits® (BCK) to equip up to 1,000 schools ... by the American College of Surgeons, U.S. Department of Defense, Department of Homeland ...
(Date:3/28/2017)... ... ... The Radiology Business Management Association (RBMA) is pleased to announce that ... Mr. Still was selected through a careful months-long search by the RBMA Board of ... our members, has been a part of building the RBMA since 1992,” said RBMA ...
(Date:3/28/2017)... Conn. (PRWEB) , ... March 28, 2017 , ... ... based in Wethersfield, Conn., has relocated its corporate headquarters to a new, more ... clients. , In October 2016, Qualidigm purchased a distressed office building in ...
(Date:3/28/2017)... ... March 28, 2017 , ... METTLER TOLEDO Process ... in power plant water and steam. , Chlorides and sulfates cause pitting and ... to extensive maintenance and unplanned shutdowns. Monitoring these ions at low ppb levels ...
(Date:3/28/2017)... ... March 28, 2017 , ... Columbus OH. Dr. Justin ... one of few medical professionals in the country to sit on the 2017 National ... Aesthetics, in just 2 years Dr. Harper helped propel the clinic from a small ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... DIEGO and VANCOUVER, British Columbia, March 27, 2017 ... ) (the "Company" or "Sophiris"), a clinical late-stage ... of patients with urological diseases, today reported fourth ... key corporate highlights. Key Corporate ... Clinical Development for Localized Prostate Cancer. During 2016, ...
(Date:3/27/2017)... , March 27, 2017 BioLineRx ... and immunology, announced today that AGI-134, an immunotherapy for the ... of Agalimmune Ltd., will be featured at the upcoming ... Washington, DC to be held on ... ...
(Date:3/27/2017)... -- The staggering cost of cancer treatment means only ... the latest treatment options against cancer. Even among the ... inadequate or no health insurance and are oftentimes saddled ... modern cancer treatment is almost non-existent for cancer patients ... mission statements of pharmaceutical and biotech companies often quote ...
Breaking Medicine Technology: