Navigation Links
Impact of AF on stroke risk eliminated with multiple risk factors
Date:8/31/2013

Dr Benn Christiansen said: "We know that atrial fibrillation increases the risk of ischemic stroke. And in patients with atrial fibrillation or previous ischemic stroke, the risk of stroke increases with the number of risk factors. But until now, little attention has been paid to the association between stroke risk and risk factors in patients without prior stroke or atrial fibrillation. We wanted to explore that association and to quantify if stroke risk was of comparable size in patients with numerous risk factors."

The study included 4,198,119 people aged 18 to 90 years with no history of stroke from nationwide Danish registries during 2000 to 2010. Of these, 161,651 (3.85%) had atrial fibrillation. The investigators compared the risk of stroke in patients with and without atrial fibrillation according to the number of risk factors.

The risk factors included in the study were myocardial infarction, peripheral artery disease, arterial embolism, excessive alcohol consumption, heart failure, carotid stenosis, retinal occlusion, chronic systemic inflammation, chronic kidney disease, venous thromboembolism, epilepsy, migraine, diabetes mellitus, hypertension and age >75 years.

The rate of stroke was calculated per 100 person-years (see figure). Patients with 0 risk factors and no atrial fibrillation had a stroke rate of 0.32 (95% confidence interval [CI] 0.31-0.32) per 100 person-years vs. 2.55 (CI=2.47-2.64) in patients with atrial fibrillation. With 1-2 risk factors present the stroke rate was 1.77 (CI=1.76-1.78) (no atrial fibrillation) and 5.69 (CI=5.61-5.78) (with atrial fibrillation).

For patients with 3-4 risk factors the stroke rates were 4.88 (CI=4.80-4.96) without atrial fibrillation vs. 6.96 (CI=6.79-7.14) with atrial fibrillation. In the presence of 5 or more risk factors stroke rates were 7.27 (CI=6.82-7.74) without atrial fibrillation vs. 8.00 (CI=7.34-8.71) with atrial fibrillation.

Dr Benn Christiansen said: "These results indicate that in patients with three or more risk factors, the risk of stroke is high regardless of the presence of atrial fibrillation. In fact, with five or more risk factors such as diabetes, hypertension, myocardial infarction, heart failure and age above 75 years, the risk associated with atrial fibrillation is eliminated."

She continued: "Our findings suggest that patients without atrial fibrillation or prior stroke may have a stroke risk that is comparable to patients with atrial fibrillation if they have three or more risk factors."

Dr Benn Christiansen concluded: "More research is needed on the effect of multiple risk factors on the risk of stroke in patients without atrial fibrillation. Stroke prevention measures may need to be tailored according to the number of risk factors."


'/>"/>

Contact: Celine Colas
press@escardio.org
44-773-005-7146
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
2. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
3. Pediatric epilepsy impacts sleep for the child and parents
4. Dartmouth researchers investigate the cognitive effects of athlete head impacts
5. Comprehensive report documents impact of urologic diseases on American public
6. New federal disclosure law may have little impact on drugs prescribed
7. After 25 years, World No Tobacco Day is making an impact
8. Sleep apnea persisting into teens can impact life skills, study finds
9. Racial make-up of community impacts obesity risk
10. LWW announces 57% growth in 2011 impact factor rankings
11. Gastroenterology, CGH maintain strong 2011 impact factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... , ... February 26, 2017 , ... NuevaCare, a leading ... diverse as Millbrae, Belmont, and Palo Alto, is proud to announce an important upgrade ... Area consumers look for home care close to home, and by having city-specific pages, ...
(Date:2/26/2017)... ... February 26, 2017 , ... ODH, Inc.™ announced today it ... at the Sheraton Pentagon City Hotel in Arlington, VA. ODH’s director of medical strategy, ... health analytics to improve Medicaid population health management. , ODH will also have an ...
(Date:2/24/2017)... Prior Lake MN (PRWEB) , ... February 24, ... ... the launch of its newly designed TaskMate Go. Core benefits and advantages built ... grain finish and a stylish, functional look and feel. Ability to gain the ...
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis of genetic ... Pittsburgh points to eight genes that may explain why susceptibility to one of the ... of a study published today in the journal npj Schizophrenia. , “There is ...
(Date:2/24/2017)... ... , ... With millions of Americans and people worldwide struggling ... are aware of our options and are empowered with strength and information throughout ... its newest edition of "Vision and Hearing" in USA Today, that will educate ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017  Today, exocad America and the Biodenta ... new path to produce 510(K) cleared, in-house milled, ... integrated into exocad DentalCAD software. In order to ... Manufacturing Processes (GMP,s) into their organization, sign up ... an audit process. Then, dental labs can use Biodenta,s ...
(Date:2/24/2017)... , Feb. 24, 2017 Zimmer Biomet Holdings, ... musculoskeletal healthcare, will present at the Cowen and Company ... Boston Marriott Copley Place on Tuesday, March 7, 2017 ... live webcast of the presentation can be accessed at ... replay following the conference via Zimmer Biomet,s Investor Relations ...
(Date:2/24/2017)... Research and Markets has announced the addition of the "Dry ... offering. ... Dry eye Drugs Price Analysis and Strategies - 2016, provides drug pricing ... answers the following questions: What are the ... they positioned in the Global Dry eye market? What ...
Breaking Medicine Technology: