Navigation Links
Immunotherapy for elderly cancer patients finds new promise in drug combination
Date:4/15/2012

SAN ANTONIO (April 16, 2012) Cancer is much more likely in the elderly than the young, and their bodies often are less prepared to fight the disease and the often-toxic side effects of treatment.

But a new study from the Cancer Therapy & Research Center at The University of Texas Health Science Center at San Antonio shows that some types of immunotherapy previously thought to work only in younger patients can be used to help the elderly, with less toxic effects than many common therapies, if combined in ways that account for age-related changes in the immune system.

"We've shown that immunotherapy for cancer not only works in aged mice, but actually can work better in aged hosts than in young counterparts by capitalizing on the immune changes that happen with age," said Tyler Curiel, M.D., MPH, a professor in the School of Medicine at the Health Science Center and principal investigator of the study, published April 15 in Cancer Research.

As you age, most parts of your body begin to wear out. They keep doing what they're made to do, Dr. Curiel said, but over time, they don't do it as well. The general perception is that the immune system also simply declines with age. "That's really too simplistic," he said. "That's really not the full picture of what's happening."

The body's immune system does weaken with age, but it also changes, and that changes the rules for fighting disease within the body. Dr. Curiel's group started by examining an immune therapy that they previously had shown to work in younger hosts, including cancer patients. It's designed to eliminate regulatory T cells (called Tregs), which are cells that turn off immune responses, allowing cancer to progress. Tregs increase in cancer. In young hosts, the drug turns off Treg activity, allowing the immune system to function better. In older hosts, even though the drug turns off the Tregs, it has no clinical benefit.

Dr. Curiel asked the question
'/>"/>

Contact: Elizabeth Allen
allenea@uthscsa.edu
210-450-2020
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New universal platform for cancer immunotherapy developed by Penn-led team
2. Fred Hutchinson Cancer Research Center to lead Immunotherapy Clinical Trials Network
3. FDA approves ipilimumab, an immunotherapy, to treat metastatic melanoma
4. Novel immunotherapy drug receives FDA approval for the treatment of metastatic melanoma
5. Addition of immunotherapy boosts pediatric cancer survival in children with neuroblastoma
6. Combined BRAF-targeted and immunotherapy shows promise for melanoma treatment
7. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
8. Dana-Farber/Provenge: Approval of prostate cancer immunotherapy-new era of cancer treatments
9. FDA Approval of new Prostate Treatment Shows Promise of Cancer Immunotherapy
10. Why is traumatic brain injury increasing among the elderly?
11. High blood glucose levels may increase kidney disease in elderly populations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... chronic illnesses can receive effective, less expensive care from a ... to a team of dedicated health care professionals, a new ... ill and need either hospitalization or a trip to the ... home clinic at the University of Texas in Houston versus ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... closing in on a "fountain of youth" drug that can ... older adults, a new study suggests. Seniors received a ... that targets a genetic signaling pathway linked to aging and ... The experimental medication, a version of the drug ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Plugin creators ... ProFire 5k. A fully customizable business presentation tool made ... “Adding the ProFire 5k business tool, users can now ... Austin, CEO of Pixel Film Studios. “ProFire 5k gives ... style to add professionalism to a presentation” , Pixel ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in the ... holiday season, AlignLife looks forward to their annual toy drive. ... Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as well ... able to give kids toys for Christmas who would be ... of our patients." , The 70 toys were donated to ...
(Date:12/24/2014)... Recently, iFitDress.com, a famous dress manufacturer and retailer, ... $150 . All these items are brand new; they are ... been updated with the new range of high quality prom ... All iFitDress.com’s designs are made according to the latest trends. ... Every outfit from the company is handpicked by skilled tailors. ...
Breaking Medicine News(10 mins):Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2
... the artery-opening devices , , FRIDAY, May 9 (HealthDay News) ... tiny tools that have extended the lives of millions ... their arteries. , The wire metal mesh tubes, when ... artery and ensure a constant supply of blood to ...
... Week with Signing Bonuses, Raises, SAGINAW, Mich., May ... Saginaw voted overwhelmingly last,night to accept their first labor ... year wage increases of 4 percent., (Logo: ... Week I have had in years. The money is,important, ...
... May 9 Brookdale Senior,Living Inc. (NYSE: BKD ... the Company at the Bank of America 2008 Health ... Mandalay Bay in Las Vegas,Nevada at 4:40 p.m. PDT ... being webcast live and can be accessed through the,Bank ...
... May 9 Tim Booth, a 20-year health,care ... CEO of PrePak Systems,Inc., a turnkey pharmaceutical packaging ... last week by the company,s parent, PrePak,Holdings, which ... and,expansion with financial support from its largest shareholders, ...
... May 9 Almost Family, Inc.,(Nasdaq: AFAM ... nursing,services, today announced that the underwriter of the ... and purchased 262,500,additional shares of common stock at ... the over-allotment, the Company sold 2,512,500 shares,in the ...
... painful periods, glaucoma, depression and many other diseases, ... -- A new class of drugs called vaptans ... of conditions including painful periods, brain hemorrhage, psychotic ... short for vasopressin-receptor antagonists, work by targeting the ...
Cached Medicine News:Health News:Drug-Coated Stents Still Spark Debate 2Health News:Drug-Coated Stents Still Spark Debate 3Health News:Saginaw Nurses Approve First Contract 2Health News:Booth Joins PrePak Systems for Growth, Expansion 2Health News:Almost Family, Inc. Announces Exercise of Over-Allotment Option 2Health News:New Class of Drugs Might Treat Many Conditions 2
(Date:12/24/2014)... -- In response to urgent requests from the Deputy Minister of ... , Direct Relief delivered two 10-bed medical tents to ... local health workers who contract Ebola while fighting the outbreak. ... was constructed for foreign health care workers who may contract ... Sierra Leonean health workers. With Sierra ...
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), ... CytoSorb® blood purification technology to help fight deadly ... 28 countries worldwide, today announced the appointment of ... FACS, as its Senior Vice President of Clinical ... Dr. Di Russo is an accomplished ...
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has announced ... Market" report to their offering. ... focuses on the developments in the self-monitoring blood glucose ... Reimbursement analysis and the effects of competitive bidding have ... SMBG meters have been performed, based on the various ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2
... WASHINGTON , July 28 Today FRC Action joined 19 pro-life groups ... requesting that Ella, a drug under consideration for FDA approval that can cause abortions but ... , , ... Vice President , made the following comments: , ...
... July 28 Delcath Systems, Inc. (Nasdaq: DCTH ) announced today ... Management Access Conference in New York, NY on Tuesday, August ... Chief Financial Officer, will review the company,s business strategy and recent corporate developments. ... Attendance at this conference is ...
Cached Medicine Technology:FRC Action and Pro-Life Coalition Urge the FDA to Reject New Abortion-Causing Drug 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: