Navigation Links
Immunotherapy: enlisting the immune system to fight cancer
Date:4/15/2008

l in Patients with Advanced Carcinoma: Abstract LB-200

A two-step drug therapy that selectively targets tumors may hold promise for some patients with advanced cancers, according to results of a clinical trial directed by researchers in London.

Scientists at the University College Londons Cancer Institute and the Royal Free Hospital used a technique called antibody-directed enzyme prodrug therapy (ADEPT) in 43 patients with previously treated, advanced colorectal, gastro-esophageal, breast, gallbladder, peritoneal, appendix, or pancreatic cancers, or cancers of unknown primary site. The patients received one, two or three ADEPT treatments over a period of two to 10 days, at dosages ranging from 37 mg/m2 to 3,226 mg/m2.

We found clinically significant responses in 44 percent of patients, said senior author Richard H. Begent, M.D., professor of oncology at the University College Londons Cancer Institute. These results support the case for conducting a randomized phase II clinical trial.

ADEPT is a two-step treatment for cancer that uses an antibody to carry an enzyme directly to the cancer cells. First, an antibody is given with an enzyme attached. Next, a prodrug (inactive anti-cancer drug) is administered. When the prodrug comes in contact with the enzyme, the resulting chemical reaction activates the anti-cancer drug, which is then able to destroy cancer cells while sparing nearby healthy tissue.

In this trial, the researchers gave patients an intravenous dose of MFECP1, a recombinant fusion protein consisting of a fragment of an antibody raised against the substance carcinoembryonic antigen (CEA), which is produced by the cancer, and carboxypeptidase

G2 (CPG2), an enzyme that activates a prodrug. Then, researchers gave patients an intravenous bis-iodo phenol mustard prodrug which is activated by the enzyme within the cancer.

Anti-enzyme antibody developed in 40 percent of patients having a singl
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Manipulating the immune system like a parasite
3. Eating Less May Hinder Immune System
4. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
5. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
6. New protein discovery helps researchers understand autoimmune diseases
7. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
8. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
9. Prime Your Immune System During the Peak of Cold Season and Beyond
10. Gene therapy trains immune system to destroy brain cancer cells and reverses behavioral deficits
11. Single microRNA fine-tunes innate immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... Barbara Bronson Gray ... (HealthDay News) -- New research suggests that a faltering ... Alzheimer,s disease, and that an inexpensive, low-tech smell test ... In two different studies, the decreased ability to ... cell function and progression to Alzheimer,s disease. "We,re ...
(Date:7/14/2014)... Kathleen Doheny HealthDay Reporter ... may be linked to multiple health issues, but dementia isn,t ... certain seniors, widowhood may even delay dementia, the researchers found. ... the spouse was associated with a later age of developing ... researcher Dr. Bryan Woodruff. Woodruff, an assistant professor ...
(Date:7/14/2014)... July 14, 2014 Skin ... its Grand Opening on Monday, July 14th, located ... The celebration will last all week through Saturday, ... patients. Everyone is welcomed to attend. The business ... provides physician-administered skincare, anti-aging, weight loss services, and ...
(Date:7/14/2014)... CA (PRWEB) July 14, 2014 Many ... of people undergo plastic surgery to reduce a “double ... market, however, eliminates the need to go under the ... that works the jaw muscles, therefore tightening the skin ... two chins. , Jawflex is used for facial exercise, ...
(Date:7/14/2014)... 2014 Since 1986, the Sheraton Premiere ... the Tysons Corner skyline and a staple within the ... known simply as “Tysons”, the iconic hotel will now ... addition to Tysons becoming its own municipality, the opening ... of Tysons brings an evolution of great magnitude and ...
Breaking Medicine News(10 mins):Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 2Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 3Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 3Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3Health News:Jawflex | Double Chin Exercise for Double Chin Reduction 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 3Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 4
... day to day life. Keeping fit costs hardly anything if ... a gym or health club,// you'll be familiar with high ... These items typically cost thousands of dollars and might be ... But you can get the same results practically for free, ...
... lasers help remove lines and wrinkled from age and ... can take its toll in later years in terms ... But, says Dr Arielle Kauvar, a dermatologist at New ... smoother, firmer appearance. ,These lasers score over ...
... of botulinum toxin eases hand spasticity among stroke survivors. Spasticity ... and it causes much disability,// because it interferes with activities ... botulinum toxin - a substance that relieves muscle tightness - ... large trial of botulinum toxin (also known as botox) in ...
... may be combined with tumor growth in mice. At ... or similar pain medications will lead to increased cancer ... further studies for managing cancer pain. ,Researchers ... of morphine, similar to doses given to cancer patients ...
... potency can be influenced by various reasons. Many advertisments ... impotence to the attention of thousands of people.// Impotence ... men are taking help, particularly as large segments of ... range from 12 million to 30 million men in ...
... An acid found naturally in the body can block the ... There is no cure for Huntington's disease (HD), which is ... But researchers at the University of Texas may be one ... with HD. ,The mice were treated with a ...
Cached Medicine News:Health News:Many factors influence sexual potency 2
(Date:7/14/2014)... July 14, 2014  Remedy Informatics, the leading ... delivery and life sciences research, announced that it ... (NPF) to build the first-ever national patient registry ... and pancreatitis. "The National Pancreas Foundation ... that thoughtful and committed organizations can effect upon ...
(Date:7/14/2014)... , July 14, 2014 Valeant ... and TSX: VRX) today announced it has filed ... Act of 1976 (HSR) with the U.S. Federal ... of Allergan, Inc. (NYSE: AGN). ... Valeant Pharmaceuticals International, Inc. (NYSE/TSX: VRX) is a ...
(Date:7/14/2014)... 14, 2014  Diomics, Inc., provider of X-Swab™, ... the United States Patent and Trademark Office has ... novel biologic sample collection materials, devices made from ... and diagnostics. The primary method ... Recovery of DNA from a number of commercially-available ...
Breaking Medicine Technology:Remedy Informatics Partners with National Pancreas Foundation to Build a National Patient Registry 2Remedy Informatics Partners with National Pancreas Foundation to Build a National Patient Registry 3Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 2Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 3Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 4Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 5Diomics Announces Issuance Of U.S. Patents For Novel Biologic Sample DNA Collection Materials For Use In Forensics And Diagnostics 2
... 2011  VIVUS, Inc. (NASDAQ: VVUS ) today ... in The American Journal of Clinical Nutrition, ... study evaluated the long-term efficacy and safety of Qnexa ... In addition to 10% sustained weight loss, the study ...
... Reportlinker.com announces that a new market research ... Global Coronary Stents Industry ... the worldwide markets for Coronary Stents in US$ ... Segments: Bare Metal Stents, and Drug Eluting Stents. ...
Cached Medicine Technology:SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 2SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 3SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 4SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 5SEQUEL Trial Results for Qnexa® Published in AJCN Show 10% Sustained Weight Loss Over 2 Years 6Global Coronary Stents Industry 2Global Coronary Stents Industry 3Global Coronary Stents Industry 4Global Coronary Stents Industry 5Global Coronary Stents Industry 6Global Coronary Stents Industry 7Global Coronary Stents Industry 8Global Coronary Stents Industry 9Global Coronary Stents Industry 10Global Coronary Stents Industry 11Global Coronary Stents Industry 12Global Coronary Stents Industry 13Global Coronary Stents Industry 14Global Coronary Stents Industry 15Global Coronary Stents Industry 16Global Coronary Stents Industry 17Global Coronary Stents Industry 18Global Coronary Stents Industry 19Global Coronary Stents Industry 20Global Coronary Stents Industry 21Global Coronary Stents Industry 22Global Coronary Stents Industry 23Global Coronary Stents Industry 24Global Coronary Stents Industry 25
... and value!, Comfortable feel and ... contoured handle , Finer control while ... action , Completely autoclavable for easy ... for recalibration , Easy-to-read precision micrometer ...
... 3730 DNA Analyzer, upgradeable to 96 capillaries, ... analysis. , Higher optical sensitivity and ... data at a lower cost. , Multiple ... Optimized polymers increase your productivity without compromising ...
... this unique offer, you can ... application. Pipetman P2 and P10 ... reagents, and P100 is perfect ... Filter Tips, which are especially ...
... an immunochromatography based one step in ... determination of Methamphetamine in human urine ... ng/mL. This assay has not been ... and is for use by Healthcare ...
Medicine Products: