Navigation Links
Immunotherapy: enlisting the immune system to fight cancer
Date:4/15/2008

rapy. In a phase I trial, they observed that a combination of GVAX immunotherapy with ipilimumab lowered prostate-specific antigen (PSA) levels in some patients.

Higher doses of ipilimumab combined with the GVAX vaccine is showing a lot of success in increasing anti-tumor activity in these patients, said Saskia J.A.M. Santegoets, Ph.D., a researcher in the Department of Pathology and Division of Immunotherapy at the Vrije Universiteit Medical Center in the Netherlands. Were encouraged by the results of this phase I trial and expect ongoing analyses to yield more valuable data about the GVAX/ ipilimumab combination.

In this trial, the vaccine was administered with escalating doses of anti-CTLA-4 (cytotoxic T-lymphocyte antigen 4) antibody ipilimumab. Researchers believe that the combination of these two immunotherapies increases ones immunity to prostate cancer.

Twelve patients were enrolled in this study. All were given the same doses of GVAX (a 500 million cell first dose followed by bi-weekly 300 million-cell doses for 24 weeks), and, in groups of three, different quantities of ipilimumab administered every four weeks (.3mg, 1mg, 3mg, or 5 mg).

Anti-tumor activity was seen in five of the six patients who received the two highest doses of ipilimumab, including PSA-level declines of greater than 50 percent; these PSA declines were maintained in four of these patients for at least six months, and up to 16 months. Among the patients with PSA-level declines, researchers noted complete resolution of multiple lesions on bone scans in two patients, resolution of cancer spread to abdominal lymph nodes in one patient, and improvement in bone pain in one patient.

The ongoing phase I trial of this combination has enrolled an additional 16 patients with hormone-resistant prostate cancer into an expansion cohort.


Evidence of Efficacy of Antibody Directed Enzyme Prodrug Therapy (ADEPT) in a Phase I Tria
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Manipulating the immune system like a parasite
3. Eating Less May Hinder Immune System
4. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
5. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
6. New protein discovery helps researchers understand autoimmune diseases
7. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
8. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
9. Prime Your Immune System During the Peak of Cold Season and Beyond
10. Gene therapy trains immune system to destroy brain cancer cells and reverses behavioral deficits
11. Single microRNA fine-tunes innate immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (PRWEB) July 28, 2014 Evolve Medical Clinics ... 2014, offering its members virtual visits and dramatic operational changes ... , Some estimates state that as many as 70% of ... “Imagine not having to leave your office or home for ... blood pressure or cholesterol,” CEO and Founder Michael R. Freedman, ...
(Date:7/28/2014)... 28, 2014 Ticket Down is ... Champions Cup Match between Manchester City and Liverpool FC ... Bronx has hosted countless big events since it opened several ... of the original Yankee Stadium, however, it has been a ... City metro area. , The Yankees Stadium is the ...
(Date:7/28/2014)... Scottsdale, Ariz (PRWEB) July 28, 2014 ... closed on a new camp property in Cornville, ... provides seriously ill children with the opportunity to ... the campers and families. The organization offers a ... ages 6-15 with chronic and life threatening illnesses ...
(Date:7/28/2014)... Quincy Bioscience, makers of the nation’s ... announce the release of the fourth edition of The ... Mark Underwood. , The Brain Health Guide is a ... for readers to improve memory and promote optimal aging. ... Brain Health Guide provides ways to help minimize common ...
(Date:7/28/2014)... Randy Dotinga HealthDay Reporter ... know it takes humans just milliseconds to look at someone,s ... a new study finds that certain facial features seem to ... The shape and size of the mouth, for example, appear ... are keys to attractiveness. The study findings suggest ...
Breaking Medicine News(10 mins):Health News:Evolve Medical Clinics to Open First Next Generation Primary and Urgent Care Facility 2Health News:Evolve Medical Clinics to Open First Next Generation Primary and Urgent Care Facility 3Health News:Evolve Medical Clinics to Open First Next Generation Primary and Urgent Care Facility 4Health News:Liverpool FC vs. Manchester City Tickets at Yankee Stadium: Ticket Down Reports Huge Demand for Guinness International Champions Cup Tickets in NYC 2Health News:Liverpool FC vs. Manchester City Tickets at Yankee Stadium: Ticket Down Reports Huge Demand for Guinness International Champions Cup Tickets in NYC 3Health News:Camp Soaring Eagle Announces New Camp Site 2Health News:Camp Soaring Eagle Announces New Camp Site 3Health News:Quincy Bioscience Launches the Fourth Edition of The Brain Health Guide 2Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3
... The Men,s Health Policy,Center, a new resource center ... that they are hosting an online petition urging,Congress ... Services (CMS) practice,that unfairly restricts prostate cancer patients, ... people who are impacted by prostate cancer to,raise ...
... The Richard B. and,Lynne V. Cheney Cardiovascular ... have joined the Institute,s Board of Directors. As ... Institute., "Mary Matalin,s experience in public affairs ... Institute as we build our organization and educate,communities ...
... Have Choices and Flexibility ... Typically Available on Larger Plans, NEW YORK, March ... employees can now choose from a wider selection of dental ... The Guardian Life Insurance Company of America (Guardian), a ...
... 27, 2008 The Cardiovascular Research Foundation (CRF) will ... mortality rates for drug-eluting stents (DES) versus bare metal ... tomorrow evening in Chicago. , The analysiswhich includes ... team of researchers led by Ajay J. Kirtane, MD, ...
... relaxation response, a stress-management approach, to other lifestyle ... of hypertension most common in the elderly. ... Massachusetts General Hospital (MGH) Hypertension Program and the ... who received relaxation response training in addition to ...
... There is new promise on the horizon for ... according to researchers at the University of Toronto. ... twitches and muscle contractions during rapid eye-movement (REM) sleep, ... at the University of Toronto, discovered that an inhibitory ...
Cached Medicine News:Health News:Men's Health Policy Center Hosts Petition to Protest Government Barrier to Prostate Cancer Medications 2Health News:Mary Matalin and John Ray Join the Cheney Cardiovascular Institute Board of Directors 2Health News:Guardian Expands Dental Benefit Options Helps Small Business Owners Lower Insurance Cost 2Health News:Guardian Expands Dental Benefit Options Helps Small Business Owners Lower Insurance Cost 3Health News:Largest ever analysis of DES data demonstrates safety, efficacy in on-and-off-label use 2Health News:Relaxation training may improve control of hard-to-treat systolic hypertension 2Health News:Relaxation training may improve control of hard-to-treat systolic hypertension 3
(Date:7/28/2014)... 28, 2014  Air Products (NYSE: APD ... oxygen is vital to any healthcare facility. This understanding ... only improve the efficiency of its oxygen supply systems, ... these systems—including systems for emergency oxygen supply ... 4-5 at the 51 st ASHE Annual ...
(Date:7/28/2014)... BIRMINGHAM, Ala. , July 28, 2014 /PRNewswire-USNewswire/ ... Arthur J. Tipton , Ph.D., President and CEO ... of the Controlled Release Society (CRS) for the ... Society,s annual meeting on July 12 in ... than 40 countries.  The Controlled ...
(Date:7/28/2014)... , July 28, 2014  A prospective study ... Sweden has validated the performance of ... and has associated volumetrically assessed breast density measurements ... Epidemiology, Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the ... tool for widespread breast cancer risk assessment," was ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4
... 26, 2012  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today ... year 2011 financial and operating results on Thursday, February 16, ... host a conference call at 8:30 AM EST that day. ... be webcast online simultaneously.  A link to the webcast may ...
... PARK, N.J., Jan. 26, 2012  Armada Health Care, ... a joint development and marketing agreement that will ... specialty pharmacy software. Armada is a leading group ... providing services such as web-based therapy management and ...
Cached Medicine Technology:Regeneron to Report Full Year 2011 Financial and Operating Results and Host Conference Call and Webcast on February 16, 2012 2Armada Health Care and Definitive Homecare Solutions Announce Alliance for Specialty Pharmacy Software and Services 2Armada Health Care and Definitive Homecare Solutions Announce Alliance for Specialty Pharmacy Software and Services 3
... new Finnpipette Focus from Thermo ... combine ergonomics with uncompromising performance. ... plate offers a custom fit ... new shorter tip cones allow ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
Inquire...
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
Medicine Products: