Navigation Links
Immunotherapy: enlisting the immune system to fight cancer
Date:4/15/2008

er at University of California, San Francisco.

In a phase 1 trial in 24 patients with metastatic prostate cancer that was unresponsive to hormone therapy, Fong and colleagues treated groups of three to six patients with increasing intravenous doses of ipilimumab (0.5, 1.5 or 3 mg/kg), a fully human anti-CTLA-4 antibody, on the first day of each 28-day treatment cycle. There were four cycles in the trial. The researchers also gave the patients 250 mg/m2/d of granulocyte-macrophage colony-stimulating factor every day for the first two weeks of each cycle.

Researchers monitored T cell activation and toxicity. They performed prostate-specific antigen (PSA) and radiographic tests at enrollment and throughout treatment to assess clinical response.

Three of the six patients treated with the highest ipilimumab dose (3.0 mg/kg x 4) had confirmed declines in PSA levels of more than 50 percent. One of these patients had a partial response in cancer that had spread to the liver.

The researchers found that activation of lymphocytes occurred primarily in the higher doses. They also could detect lymphocytes targeting proteins expressed by prostate cancer cells in some patients following treatment.

Immune-related side effects -- including skin rash, diarrhea and a deficiency in pituitary hormone production -- were most common in the group receiving the higher ipilimumab doses.

Fong and colleagues will continue to study CTLA-4 blockade. We are studying higher doses of anti-CTLA-4 antibody and look forward to beginning a larger phase 2 trial in the next three to six months, Fong said.


Dendritic and T cell functions in patients with metastatic hormone-refractory prostate cancer treated with GVAX immunotherapy for prostate cancer and ipilumumab: Abstract 2538

Researchers have found a promising synergy of two therapies to treat metastatic prostate cancer that is resistant to hormone the
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Manipulating the immune system like a parasite
3. Eating Less May Hinder Immune System
4. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
5. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
6. New protein discovery helps researchers understand autoimmune diseases
7. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
8. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
9. Prime Your Immune System During the Peak of Cold Season and Beyond
10. Gene therapy trains immune system to destroy brain cancer cells and reverses behavioral deficits
11. Single microRNA fine-tunes innate immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... , ... Banc Intranets recently entered into a strategic partnership with ... City, Tenn.-based firms to work synergistically to promote similar products to the same market. ... organizations in the financial, commercial and services sectors. The software, which is sold by ...
(Date:8/27/2015)... ... 2015 , ... For the first time, Ninja® introduces Nutrient ... Ninja® Auto-iQ Pro Complete and Nutri Ninja Auto-iQ Compact System. These two exciting ... to a whole new level. This line of Nutri Ninja products is designed ...
(Date:8/27/2015)... Springs, FL (PRWEB) , ... August 27, 2015 , ... Florida Hospital North Pinellas, located ... Palm Harbor in the Fall of 2016. The new facility will be located at US ... , The property closed on August 18, and work on the project is slated ...
(Date:8/27/2015)... NY (PRWEB) , ... August 27, 2015 , ... King ... this August. Founded by Michael J. Cullen in 1930 and recognized by the ... forever. , Still family owned and operated, the Cullen & Kennedy families have ...
(Date:8/27/2015)... ... August 27, 2015 , ... Since its launch ... to having twelve offices in three counties, LA, Orange and San Bernardino. ... region. Founded by Dr. Richy Agajanian, the Oncology Institute of Hope and ...
Breaking Medicine News(10 mins):Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 2Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 3Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 4Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 2Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 3Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 4Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 2Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 3Health News:King Kullen Honors Their 85 Years of Success this August 2Health News:California’s Largest Private Oncology Practice Serves 50,000 Patients in 8 years 2
...
... today announced that the U.S. Court of Appeals for ... reversal of the district court judgment in its ... ,On February 22, 2007, the district court for ... of Pfizer and Mylan immediately appealed and has continued ...
... WASHINGTON, "Prospective parents can take positive lifestyle steps to ... with a healthy heart," says the American Heart ... Council on Cardiovascular Disease in the Young and endorsed ... knowledge reflected in medical and scientific literature and identified ...
... of California scientists have found that cancer drug enhances ... ,A protein complex called chromatin causes ... shortens as it coils. When chromatin loosens, genes associated ... shown that the protein CBP causes chromatin to relax, ...
... in the June issue of the journal Cell Metabolism, published ... result in increased levels of a newly identified 'starvation ... show that the hormone plays a critical role in the ... and in those fed an Atkins-like diet. ,That ...
... studies on the cardiovascular effects of HRT, the level ... heart disease (CHD) remains controversial, according to BMJ ... an editorial published today, BMJ Clinical Evidence reports that ... reduces the risks of CHD, the Womens Health Initiative ...
Cached Medicine News:Health News:Women of Child-Bearing Age Urged to Take a Multivitamin With Folic Acid 2Health News:Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory 2Health News:Effects of 'starvation Hormone'-Newly Identified in Low-carb Diets 2
(Date:8/27/2015)... Aug. 27, 2015   Proxsys Rx, ... (IOPP™) is expanding its population health management ... transition of care program for hospitals and ... provides hospitals with technology systems and pharmacy ... that have been mandated by Center for ...
(Date:8/27/2015)... Aug. 27, 2015   NineSigma the leading innovation ... $450M in estimated overall revenue growth and anticipates the creation ... Frontier Open Innovation Incentive (OII). In 2013, ... a grant of over $2 million to accelerate adoption of ... $10 Million and $1 Billion in revenues. To date over ...
(Date:8/27/2015)... August 27, 2015 According to ... by Type (Integrated, Standalone), by Deployment Mode (Web based, ... Emergency Healthcare Service Providers), by Component - Global Trends ... Market is estimated at $501.1 Million 2014, and is ... CAGR of 7.6% from 2014 to 2019. ...
Breaking Medicine Technology:Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2State of Ohio and NineSigma Collaborate to Drive Regional Economic Growth and Job Creation 2State of Ohio and NineSigma Collaborate to Drive Regional Economic Growth and Job Creation 3Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 4
... , SANTA MONICA, Calif. and ... QUOSA, Inc., today announced that Cubist Pharmaceuticals ... between Reprints Desk,s STM Document Delivery service with QUOSA,s ... literature re-use. The integrated solution features integration with ...
... , SOUTH SAN FRANCISCO, Calif., Dec. 9 Anesiva, ... 3, 2009, Anesiva entered into an Asset Purchase Agreement which ... Technologies, Ltd., dated November 30, 2009, and sold certain assets ... British Virgin Island LLC, and Lee,s Pharmaceuticals (HK) Limited (Lee,s ...
Cached Medicine Technology:Cubist Pharmaceuticals Becomes First Company to Implement Integrated Reprints Desk Document Delivery and QUOSA Scientific Literature Workflow Solution 2Cubist Pharmaceuticals Becomes First Company to Implement Integrated Reprints Desk Document Delivery and QUOSA Scientific Literature Workflow Solution 3Anesiva Completes Sale of its Zingo(TM) Assets to Powder Pharmaceuticals and Lee's Pharmaceuticals 2
... provides optimized balance of pulse strength, pulse ... cleaning in the O.R. Unlike disposable plastic ... forged in die-cast metal and powered by ... The result is unparalleled performance in cleaning, ...
Used for arthroscopic or open shoulder surgery. Powered positioning of back section inclines from 0 degrees to 90 degrees. Removable shoulder panels provide an eight-inch (203-mm) access area behind ...
... 1st MPJ IMPLANT SYSTEM is a unique ... of the 1st metatarsal phalangeal joint resulting ... revision of a previous arthroplasty. The ... pain relief, superior function and longevity. ...
... play an important part in our daily ... rheumatic changes can cause severe handicaps. A ... finger-joint prostheses was to produce a reconstructed ... function as nearly possible.,The cementless RM Finger ...
Medicine Products: