Navigation Links
Immunotherapy: enlisting the immune system to fight cancer
Date:4/15/2008

redirecting all of these complex immune responses and targeting them against cancer, Rothman said.

The researchers divided the patients into three groups of five; each group received two doses of either 1x109, 3.3x109 or 1x1010 units of Listeria at three-week intervals. They administered ampicillin five days after each dose, first intravenously and then orally for 10 days.

Each patient developed flu-like symptoms, including fever, chills and nausea with or without vomiting. In the lower doses, these symptoms were treated with non-prescription non-steroidal anti-inflammatory drugs (NSAIDs) and anti-emetics. Patients in the highest dose group had the same but more severe symptoms.

Rothman used the RECIST criteria to assess the tumors in 13 patients. At the end of the study, five patients had progression of their cancer, seven were stable, and one patient showed a partial response to the therapy. Three of the seven stable patients had tumor reductions of about 20 percent.

The partial response patient who was stage IVb at trial initiation was given six chemotherapy courses and a radical hysterectomy. Currently, she is tumor- free and her blood tests are normal. Six of the 13 patients are surviving, with a median survival of 424 days. Median survival for all 15 treated patients is 327 days.


CTLA-4 blockade for hormone refractory prostate cancer: dose-dependent induction of CD8+ T cell activation and clinical responses: Abstract 2539

Blocking CTLA-4, a cellular molecule on lymphocytes that inhibits immune response, produced meaningful clinical benefits in patients with prostate cancer that hadnt responded to hormone therapy, according to researchers.

CTLA-4 blockade works by removing the brakes on the immune system. Our results show that enhancing immune responses in prostate cancer patients can lead to clinical responses, said Lawrence Fong, M.D., a hematology/oncology research
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Manipulating the immune system like a parasite
3. Eating Less May Hinder Immune System
4. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
5. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
6. New protein discovery helps researchers understand autoimmune diseases
7. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
8. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
9. Prime Your Immune System During the Peak of Cold Season and Beyond
10. Gene therapy trains immune system to destroy brain cancer cells and reverses behavioral deficits
11. Single microRNA fine-tunes innate immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... 02, 2015 Tronics, a designer and ... growth strategy to benefit from the significant growth expected ... May 2015 Status of the MEMS Industry report, we ... reach $6.6B in 2020,” says Frederic Breussin, Business Unit ... , The analyst adds that “although the BioMEMS market ...
(Date:6/2/2015)... June 02, 2015 Erbelli’s Gourmet Pizzeria, ... to promote its handmade gourmet pizzas and calzones, fresh ... the website is new, the recipes are not—they have ... The main feature of the site is the menu, ... and descriptions of all the items. You can order ...
(Date:6/2/2015)... OR (PRWEB) June 02, 2015 ZOOM+, ... of ZOOM+ Performance Health Insurance, announced today the opening ... Clean White 57 - a three-in-one complete dental exam, ... Clean Jr. for kids. Like all ZOOM+ services, ZOOM+Smile ... , “Why shouldn’t the dentist office be as inviting ...
(Date:6/2/2015)... Vancouver, BC (PRWEB) June 02, 2015 ... to announce the opening of Surrey’s first ... cities and boasts a diverse, young community, ... communities. http://www.theglobeandmail.com/news/british-columbia/four-reasons-bcs-fastest-growing-city-is-a-political-powerhouse/article21408253/ , Until now ... have had to come into Vancouver ...
(Date:6/2/2015)... 02, 2015 TU-Automotive Detroit is the ... The 150+ speakers include senior execs from GM, Chrysler, ... will provide a crucial status update on the automotive ... is just 24 hours to secure one of the ... can’t wait for tomorrow. There are 70 sessions looking ...
Breaking Medicine News(10 mins):Health News:Tronics Aims to Benefit from Major Growth of Sensors and Related Technologies for Healthcare Applications 2Health News:Erbelli’s of Bradenton Launches New Mobile-Friendly Website 2Health News:ZOOM+ Opens Its First On-Demand ZOOM+Smile Studio and Reinvents the Dental Exam 2Health News:Olive Fertility Centre Opens First Fertility Clinic in Surrey BC 2Health News:The Connected Car’s Biggest Event is Here – TU-Automotive Detroit 2015 2
... One-third of immigrant children and more than 70 ... five years or less lack health coverage, a Rutgers ... Access to Care of New Jersey Immigrants," by the ... immigrants face significant access-to-care barriers and their lack of ...
... publication in The Endocrine Society,s Journal of Clinical Endocrinology ... the diabetes drug metformin may prevent or delay the development ... affects 7 to 10 percent of women of childbearing age ... estimated 5 to 6 million women in the United States, ...
... June 28 (HealthDay News) -- Preventing type 2 diabetes not only ... bit of money. By treating people who were at ... by $2,600 for each person enrolled in a lifestyle changes group, ... metformin over the course of 10 years. But when ...
... Reporter , TUESDAY, June 28 (HealthDay News) -- A vaccine ... some promise, while another designed to alter insulin production fails, ... results of both studies were slated to be presented Tuesday ... Type 1 diabetes often appears early in life and ...
... June 28 (HealthDay News) -- Some HIV patients experience ... new research suggests that the reason why is because ... small group of supporting brain cells called astrocytes. ... that protects the brain from harmful chemicals and toxins. ...
... PARK, Md. - Four Mid-Atlantic States are teaming up ... aimed at replacing old, highly polluting trucks. Led ... Air Management Association (MARAMA), the new program will target ... major ports, warehouses and local stores. The ...
Cached Medicine News:Health News:Rutgers study: Third of N.J. immigrant children, many adult newcomers lack health insurance 2Health News:Diabetes drug may prevent or delay development of polycystic ovary syndrome 2Health News:Preventing Type 2 Diabetes Saves Money: Study 2Health News:Preventing Type 2 Diabetes Saves Money: Study 3Health News:Trials of Type 1 Diabetes Vaccines Bring Mixed Results 2Health News:Trials of Type 1 Diabetes Vaccines Bring Mixed Results 3Health News:Research Sheds Light on Cause of Brain Deficits in HIV Patients 2Health News:Mid-Atlantic states' unique plan to replace region's dirtiest trucks 2Health News:Mid-Atlantic states' unique plan to replace region's dirtiest trucks 3
(Date:6/2/2015)... Minn., June 2, 2015  MGC Diagnostics Corporation ... company, today reported financial results for the second ... 2015 second quarter domestic equipment, supplies and accessories ... flat at $4.2 million.  During the quarter, competitive ... revenue, compared to 12 accounts, or $850,000 in ...
(Date:6/2/2015)... , June 2, 2015 REPORT HIGHLIGHTS ... at nearly $3.7 billion in 2013. This market is expected ... nearly $7.8 billion in 2019, with compound annual growth rate ... 2019. This report provides: An in-depth ... of global market trends, with data from 2013, estimates for ...
(Date:6/2/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/d8nj6b/europe ) ... Market - Growth, Trends And Forecasts (2014 - 2019)" ... market for Fluoroscopy is expected to grow at a ... is used to view the gastrointestinal tract, to direct ... ducts or the urinary system, to open narrowed or ...
Breaking Medicine Technology:MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 2MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 3MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 4MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 5MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 6MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 7MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 8MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 9MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 10MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 11MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 12MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 13MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 14Global Markets and Technologies for Medical Lasers 2European Fluoroscopy Market Report 2014-2019 - Growth, Trends And Forecasts 2
... miniature arrayed detector ?uorometer ... for ?uorescence applications from ... light source modules provide ... ?uorescence measurement which are ...
The Fluoroskan Ascent FL is equipped with both fluorometric and luminometric measurement technologies, providing a full coverage for fluorometric, glow and flash luminometric applications even in the...
... Fluorometer utilizes unique microprocessor-controlled filter wheels for ... optics. The filter wheels can be programmed ... of applications. With this fluorometer, you do ... or two wavelengths. The C&L Dye Fluorometer ...
The VICTOR² D fluorometer is suitable for clinical assays based on fluorescence or time-resolved fluorescence from a wide variety of plates....
Medicine Products: