Navigation Links
Immunotherapy: enlisting the immune system to fight cancer
Date:4/15/2008

SAN DIEGO Researchers are directing the bodys immune system to shrink tumors and prevent new ones from forming. Data presented at the 2008 Annual Meeting of the American Association for Cancer Research, April 12-16, detail how cellular strategies and new vaccines are changing the cancer treatment landscape.


The first use of a live listeria cancer vaccine in man: Abstract 225

Phase I/II trial results have shown that the live Listeria cancer vaccine, Lovaxin C, is safe for humans. In addition, three women in the cervical cancer trial had approximately 20 percent tumor reductions, researchers report.

We are using Listeria to deliver tumor-specific antigens to the immune system in a manner that results in maximal immune and tumor-clearing response, said John Rothman, Ph.D., vice president of clinical development at Advaxis, which is developing Lovaxin C.

The trial included 15 women with progressive, recurrent or advanced cervical cancer. All patients had failed chemotherapy, radiotherapy or surgery. The women had metastatic disease and most were stage IVb.

Listeria monocytogenes infects antigen presenting cells (APCs) a very special piece of immune real estate, Rothman said. These cells consume foreign invaders and instruct the immune system to attack them. Listeria thrives within APCs and thus directs an immune response.

We bioengineer Listeria both to attenuate it and to cause it to secrete a tumor-specific antigen fused to a listerial protein, which makes it more effective than Listeria that just secretes the tumor antigen, Rothman said. By doing this we focus a very strong immune attack against the antigen in question, which is typically specific to a tumor.

What were doing is taking a lot of evolution that enabled Listeria to infect human immune systems, and an equal amount of evolution that enables humans to get rid of Listeria once this occurs. We are then co-opting and
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Manipulating the immune system like a parasite
3. Eating Less May Hinder Immune System
4. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
5. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
6. New protein discovery helps researchers understand autoimmune diseases
7. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
8. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
9. Prime Your Immune System During the Peak of Cold Season and Beyond
10. Gene therapy trains immune system to destroy brain cancer cells and reverses behavioral deficits
11. Single microRNA fine-tunes innate immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 23, 2015 AngelWeddingDress, the premier ... 2015 maternity wedding dresses. View website of ... looking for maternity wedding dresses online for a bridal ... with high quality for them. Its maternity wedding dresses ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... 2015 Thousand of GranuFlo lawsuits ( ... its GranuFlo and NaturaLyte dialysis concentrates continue to move ... District Court, District of Massachusetts, Bernstein Liebhard LLP reports. ... has remanded a case filed by the state of ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... 22, 2015 Joan Lunden, award-winning American ... at the upcoming 32nd Annual Miami Breast Cancer ... Education Resource®, LLC (PER®) , shares that “a fast-growing, ... undetected if she had not followed up her clean ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... several months,senior leadership at Anthem Blue Cross has been ... of Managed Health Care,to bring closure to all issues ... the DMHC during this period and have,scheduled time with ... proposal., Following are the key elements of our ...
... Guidelines for the treatment of older patients with respiratory ... open access journal BMC Health Services Research ... small minority of eligible patients. , Benjamin Craig from ... who investigated the treatment of nearly 30,000 patients across ...
... New review article in leading hypertension journal suggests that increasing, ... of ... that are good sources of potassium and low in sodium ... of high blood pressure and stroke, ENGLEWOOD CLIFFS, N.J., July ...
... Both the Alliance Defense Fund & Keys,for Networking, ... Court,in support of attorney Jeffery M. Leving,s Petition for ... Certiorari on behalf of Daryl,Hendrix, a Topeka sperm donor, ... Mr. Hendrix donated his genetic material to attorney ...
... previously thought to promote colorectal cancer instead suppresses the ... UT Southwestern Medical Center have found. , "This finding ... said Dr. Lawrence Lum, assistant professor of cell biology ... which appears online today and in a future issue ...
... University HealthSystem,Consortium (UHC), welcomes Susan K. Pingleton, MD, to ... has more than 20 years of,experience in academic internal ... School of Medicine where she served as the Peter ... Dr.,Pingleton was the Petersdorf Scholar in Residence at the ...
Cached Medicine News:Health News:Anthem Blue Cross Statement on Settlement Discussions with the California Department of Managed Health Care 2Health News:Guidelines for care of elderly patients ignored 2Health News:Unilever Unveils Promise(R) SuperShots(R) for Blood Pressure, the First Functional Shot to Increase Daily Potassium Intake to Help Reduce the Risk of High Blood Pressure 2Health News:Unilever Unveils Promise(R) SuperShots(R) for Blood Pressure, the First Functional Shot to Increase Daily Potassium Intake to Help Reduce the Risk of High Blood Pressure 3Health News:Unilever Unveils Promise(R) SuperShots(R) for Blood Pressure, the First Functional Shot to Increase Daily Potassium Intake to Help Reduce the Risk of High Blood Pressure 4Health News:Unilever Unveils Promise(R) SuperShots(R) for Blood Pressure, the First Functional Shot to Increase Daily Potassium Intake to Help Reduce the Risk of High Blood Pressure 5Health News:Sperm Donor Fights for His Rights as a Father in U.S. Supreme Court 2Health News:Sperm Donor Fights for His Rights as a Father in U.S. Supreme Court 3Health News:Protein thought to promote cancer instead functions as a tumor suppressor 2Health News:University HealthSystem Consortium Names Susan K. Pingleton, MD, as Its Chief Learning Officer 2
(Date:1/23/2015)... Africa , Jan. 23, 2015   Leatt Corporation ... personal protective equipment for all forms of sports, including ... Leatt-Brace® neck brace, announced today that the UISP Lega ... now requires all riders to wear a neck brace ...
(Date:1/23/2015)... Jan. 23, 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... in the development and sale of patented biopharmaceutical medicine, ... pharmaceutical ingredients (API) today announced the business and development ... 1. Following the September 2014 JCM application ...
(Date:1/22/2015)... 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the ... therapies for cardiovascular disease and overall health is pleased to ... 2014 and its outlook for 2015 from the CEO, Mr. ... We would like to take this opportunity to share ...
Breaking Medicine Technology:Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... WIRE)--Jun 18, 2007 - Novelos,Therapeutics, Inc. (OTCBB: ... of therapeutics to treat cancer and,hepatitis, today ... Care (DF/PCC) Phase 2 trial of NOV-002,in ... To date, 10 patients were evaluable for ...
... Calif.--(BUSINESS WIRE)--Jun 19, 2007 - Geron,Corporation (Nasdaq: ... production, survival following engraftment and,positive impact on ... for GRNCM1, the company's human embryonic stem ... International,Society for Stem Cell Research (ISSCR) Annual ...
Cached Medicine Technology:Novelos Therapeutics Announces Encouraging Results in Ongoing Phase,2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care 2Novelos Therapeutics Announces Encouraging Results in Ongoing Phase,2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care 3Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure 2Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure 3Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure 4Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure 5Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure 6
... These specialty Eraser instruments have been ... with the right tool for situations ... a series of 25 gauge intraocular, ... discrete treatment of target tissues for ...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 5/box....
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
Titanium. Straight shafts with curved lower tip. Upper tip fits into positioning hole while lower jaw stabilizes the lens. Flat smooth handle with dull finish. Most popular size or model....
Medicine Products: