Navigation Links
Immunization for MRSA on the horizon
Date:2/14/2012

Methicillin resistant staph aureus (MRSA) infections are resistant to antibiotics and can cause a myriad of problems -- bone erosion, or osteomyelitis, which shorten the effective life of an implant and greatly hinder replacement of that implant. MRSA can result in prolonged disability, amputation and even death.

Although only 2 percent of the American population that undergo total joint replacement surgery will suffer an infection, half of those infections are from MRSA. The results of a MRSA infection after a total joint replacement can be devastating. Currently, there is no effective treatment for MRSA-infected implants. With the increasing incidence of total joint replacement surgeries, the prevalence of MRSA-infected implants is expected to rise.

A team of investigators from the University of Rochester Medical Center has developed a vaccine that can prevent bacterial infection of orthopaedic implants. Their findings were presented at the Orthopaedic Research Society (ORS) 2012 Annual Meeting in San Francisco, California.

The team, led by Edward Schwarz, PhD, Professor of Orthopaedics and Associate Director of the Center for Musculoskeletal Research, has generated an antibody that prevents MRSA bacteria from dividing properly.

"What makes the staph such a challenging pathogen is that is has an ironclad cell wall. But that is also its Achilles' heel," Dr. Schwarz said. He explained that if the cell wants to divide, it has to "unzip the cell wall" to break into two "daughter cells." Their team produced an antibody that targets a component of the zipper, Gmdpreventing normal bacterial cell division by causing them to form clusters of cells.

The researchers tested the antibody prior to implantation of a MRSA-infected pin to simulate an infected joint replacement. They monitored bacterial growth and found that their antibody protected 50 percent of their sample from infection. Further analysis found that the antibody prevented formation of sequestrum, or a piece of dead bone, which is a hallmark of osteomyelitis. Additionally, immunization led to decreased bacterial presence on the pins themselves.

Based on these findings, this immunization appears to be a promising treatment to prevent the MRSA infection/reinfection of orthopaedic implants.

Dr. Schwarz and his team were recently awarded a five-year multimillion dollar grant from AOTrauma, a not for profit Swiss foundation, for the Clinical Priority Program grant on infection. This grant deals with the diagnosis, treatment, prevention, and education about musculoskeletal infection.


'/>"/>

Contact: Annie Hayashi
hayashi@ors.org
847-430-5025
Orthopaedic Research Society (ORS)
Source:Eurekalert

Related medicine news :

1. Families Fighting Flu Commends the CDCs Advisory Committee on Immunization Practices Recommendation for Universal Influenza Vaccination
2. Pharmacists Play a Vital Role in Providing Immunizations in Their Communities
3. STC Releases iPhone Application to Track Your Immunization Records – MyIR™
4. New study finds reminders for immunizations challenging for pediatric practices
5. Salivary glands as organs of immunity: New research makes oral immunization easier to swallow
6. Immunization not linked to increased hospitalization for children with inherited disorder
7. Study finds many gastroenterologists unaware of appropriate immunizations for IBD patients
8. Washington pediatricians receive regular requests for alternative child immunization schedules
9. Adult immunization needs to move up the health check list
10. Best way to boost adult immunizations is through office-based action, study finds
11. Healthcare Reform is on the Horizon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... , ... AlignLife clinics nationwide are giving back to their communities by collecting ... bountiful gifts wrapped tightly under a Christmas Tree. AlignLife hopes to spread the ... , In exchange for generous donations, customers will receive a gift in return. ...
(Date:12/7/2016)... ... 2016 (PRWEB) (PRWEB) December 07, 2016 , ... Man’s best ... Dermatitis Associated with Borrelia Infection” reveals that a condition similar to ... prestigious Journal of Veterinary Science & Medical Diagnosis. , Morgellons disease is an ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu cosmetic ... redesigned website, which launched October 17, 2016, features comprehensive information regarding a wide ... layout. Visitors and patients can discover the latest clinical dermatology treatments for medical ...
(Date:12/7/2016)... ... December 07, 2016 , ... Delete® - Tattoo Removal and Laser ... Holiday Party Season. Save Up To 33% Off Botox® and Juvederm® Products Now Through ... Phoenix Valley with Delightful Deals on Botox® and Juvederm® just in time ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... Campaign Winner in the Folio: Marketing Awards competition. Live From won in the ... in pioneering, inventive, and ultimately successful projects undertaken by the media industry’s most ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... ZIONA SCIENCE PARK , Israel ... company Kadimastem (TASE: KDST) announced today the signing of a memorandum ... between the companies. The synergy between the companies will assist in ... as a worldwide leader in innovative treatment for severe diseases in ... ...
(Date:12/7/2016)... 7, 2016  Organovo Holdings, Inc. (NASDAQ: ... focused on delivering scientific and medical breakthroughs using ... and Chief Executive Officer Keith Murphy ... December 14, 2016 at 1:00 p.m. Eastern Time ... yet familiar with the Company, an informational video ...
(Date:12/7/2016)... The global  blood screening ... USD 3.9 billion by 2024, based on a ... growth of the market is attributed to the ... by the market players. Demand for blood screening ... rising awareness about transfusion-transmitted diseases, and technological developments ...
Breaking Medicine Technology: