Navigation Links
Immunization for MRSA on the horizon
Date:2/14/2012

Methicillin resistant staph aureus (MRSA) infections are resistant to antibiotics and can cause a myriad of problems -- bone erosion, or osteomyelitis, which shorten the effective life of an implant and greatly hinder replacement of that implant. MRSA can result in prolonged disability, amputation and even death.

Although only 2 percent of the American population that undergo total joint replacement surgery will suffer an infection, half of those infections are from MRSA. The results of a MRSA infection after a total joint replacement can be devastating. Currently, there is no effective treatment for MRSA-infected implants. With the increasing incidence of total joint replacement surgeries, the prevalence of MRSA-infected implants is expected to rise.

A team of investigators from the University of Rochester Medical Center has developed a vaccine that can prevent bacterial infection of orthopaedic implants. Their findings were presented at the Orthopaedic Research Society (ORS) 2012 Annual Meeting in San Francisco, California.

The team, led by Edward Schwarz, PhD, Professor of Orthopaedics and Associate Director of the Center for Musculoskeletal Research, has generated an antibody that prevents MRSA bacteria from dividing properly.

"What makes the staph such a challenging pathogen is that is has an ironclad cell wall. But that is also its Achilles' heel," Dr. Schwarz said. He explained that if the cell wants to divide, it has to "unzip the cell wall" to break into two "daughter cells." Their team produced an antibody that targets a component of the zipper, Gmdpreventing normal bacterial cell division by causing them to form clusters of cells.

The researchers tested the antibody prior to implantation of a MRSA-infected pin to simulate an infected joint replacement. They monitored bacterial growth and found that their antibody protected 50 percent of their sample from infection. Further analysis found that the antibody prevented formation of sequestrum, or a piece of dead bone, which is a hallmark of osteomyelitis. Additionally, immunization led to decreased bacterial presence on the pins themselves.

Based on these findings, this immunization appears to be a promising treatment to prevent the MRSA infection/reinfection of orthopaedic implants.

Dr. Schwarz and his team were recently awarded a five-year multimillion dollar grant from AOTrauma, a not for profit Swiss foundation, for the Clinical Priority Program grant on infection. This grant deals with the diagnosis, treatment, prevention, and education about musculoskeletal infection.


'/>"/>

Contact: Annie Hayashi
hayashi@ors.org
847-430-5025
Orthopaedic Research Society (ORS)
Source:Eurekalert

Related medicine news :

1. Families Fighting Flu Commends the CDCs Advisory Committee on Immunization Practices Recommendation for Universal Influenza Vaccination
2. Pharmacists Play a Vital Role in Providing Immunizations in Their Communities
3. STC Releases iPhone Application to Track Your Immunization Records – MyIR™
4. New study finds reminders for immunizations challenging for pediatric practices
5. Salivary glands as organs of immunity: New research makes oral immunization easier to swallow
6. Immunization not linked to increased hospitalization for children with inherited disorder
7. Study finds many gastroenterologists unaware of appropriate immunizations for IBD patients
8. Washington pediatricians receive regular requests for alternative child immunization schedules
9. Adult immunization needs to move up the health check list
10. Best way to boost adult immunizations is through office-based action, study finds
11. Healthcare Reform is on the Horizon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: