Navigation Links
Immune system's bare essentials used to speedily detect drug targets
Date:10/31/2010

methods, which rely on sequencing, or identifying every single peptide in the antigen's make-up, one after another. Such sequencing can take months, or even years, to identify possible T cell binding sites.

"The added beauty of our system is that the entire process can be done in the lab, so we do not have to perform tests in people," says Sadegh-Nasseri, who has a patent pending for the new test.

The Johns Hopkins team, including co-lead investigators AeRyon Kim, Ph.D., and Isamu Hartman, Ph.D., also immunologists, based their test on nearly 20 years of the team's previous research into how immune system cells selectively process antigens and the maze of possible protein combinations inside. That cumulative research led them to narrow their search to five essential and well-described proteins involved in antigen processing by immune system cells.

In their latest series of experiments, the team tested a mix of the selected immune system proteins to see if it could accurately detect two already known epitopes, those of the Texas strain of the influenza virus and type II collagen, both widely used experimental antigens. Then, they used the mix to find unknown epitopes for portions of the influenza virus that causes avian flu and for the parasite involved in malaria.

Chief among the epitope-mapping test's chemical components was a protein molecule common to all the body's immune system cells, called HLA-DR. This molecule is one of the most common binding molecules used in the natural immune system's peptide selection process. HLA stands for human leukocyte antigen, and HLA-DR is produced in a gene-dense region of the body's immune system, the major histocompatibility complex.

Other key chemicals in the make-up were HLA-DM, another protein compound that disrupts the binding of HLA-DR molecules to an antigen if the fit is not perfect, and three of the most common enzymes, so-called cathepsins, involved in breaking up
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Certain cancer therapies success depends on presence of immune cell, Stanford study shows in mice
2. Mount Sinai researchers discover origin of immune cells in the brain
3. Virginia Bioinformatics Institute to model immune responses to gut pathogens
4. Cell survival protein discovery rewrites immune system story
5. Melanoma uses bodys immune system to spread to lungs
6. Air pollution alters immune function, worsens asthma symptoms
7. OHSU research reveals possible method for boosting the immune system to protect infants against HIV
8. Immune System Genes Show Links to Type 1 Diabetes
9. Adults demonstrate modified immune response after receiving massage, Cedars-Sinai researchers show
10. Scientists discover the mechanisms and function of a type of mysterious immune cell
11. Researchers closer to development of drug to prevent deadly immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Chinese technology company, Elink-IOT, has launched ... raise AUD$150,000 to finalize development of Watcher, the world’s ... watch designed to help the owner keep track of ... the item is out of range. , Using ... wearer and sends alerts on its E-paper display, and ...
(Date:5/6/2015)... The future of nursing is influenced by ... an increase in educational requirements. Leslie Brown, branch manager ... insight on these trends and how a travel nurse ... that exist in the nursing field. , Technology ... has been prevalent across the U.S. ever since the HITECH ...
(Date:5/6/2015)... York, NY (PRWEB) May 06, 2015 ... producer in New York City, announced today that it ... Creative Awards for a presentation video produced on behalf ... award in the category of motion graphics. , The ... Professionals (AMCP), received over 6000 entries from 22 countries. ...
(Date:5/6/2015)... 2015 “ Radiation Island ” was featured ... a look at the latest and coolest applications on the ... of AppWatch and technology expert, conducted the app review and ... graphic games on iOS. , Touted as one of the ... loved by users, which is obvious because of its rating ...
(Date:5/5/2015)... 06, 2015 Social Media Regulatory Affairs ... Media Your Most Powerful Marketing Tool and Get the ... http://www.fdanews.com/SocialMedia , Social media … Is it ... media’s reach. Patients are using it — learning about ... what they’ve discovered. , But, it can become a ...
Breaking Medicine News(10 mins):Health News:Crowdfunding campaign Launched for World’s First Anti-Loss Smart Watch 2Health News:National Nurses Week: Exciting Travel Nursing Trends Discussed with a Healthcare Staffing Expert 2Health News:National Nurses Week: Exciting Travel Nursing Trends Discussed with a Healthcare Staffing Expert 3Health News:National Nurses Week: Exciting Travel Nursing Trends Discussed with a Healthcare Staffing Expert 4Health News:The SGNY Group Wins Platinum Hermes Creative Award 2Health News:Top Grossing iPhone Game, Radiation Island, Was Featured on NewsWatch 2Health News:FDAnews Announces: Social Media Regulatory Affairs Summit, June 24-26, 2015 2Health News:FDAnews Announces: Social Media Regulatory Affairs Summit, June 24-26, 2015 3Health News:FDAnews Announces: Social Media Regulatory Affairs Summit, June 24-26, 2015 4
... , KAYUNGA, Uganda, July 10 Uganda was the first ... national prevalence in HIV. The epidemic, however, remains serious as ... field have begun promoting a low cost and powerful weapon ... , Three trials in Kenya, Uganda and South Africa have ...
... Inc., the parent company of Ruth,s Chris Steak House, announced ... Street Ruth,s Chris Steak House to Tulane University for the ... a neighborhood-based medical home that will provide care to patients ... The building will honor the restaurant company,s founder, Ruth ...
... Newswise -- President Obama today announced that two Fred ... nation,s highest honor for scientists at the beginning of ... Ph.D., and cancer-prevention researcher Ulrike "Riki" Peters, Ph.D., are ... Early Career Award for Scientists and Engineers (PECASE). Each ...
... 10 Looking to reinforce its positioning as the city,s pre-eminent ... advertising campaign that speaks to New Yorkers as only a born ... "Your city. Your drugstore. Duane Reade", the campaign will ... as well as on phone kiosks, billboards and urban panels near ...
... , ... J-1/H-1B foreign physician immigration conference and job fair series announced by Pederson Immigration Law ... ... announced the details today for the 2009 J-1/H-1B Foreign Physician Immigration Conference and Job ...
... Earvin "Magic" Johnson, Chairman and Founder of the Magic ... Michaels Scholarship Program Life Skills Leadership Conference in Los ... scholarship students attending. They come from all around the ... entertain and empower. The Taylor Michaels Scholarship Program (TMSP) ...
Cached Medicine News:Health News:Ugandan Medical Male Circumcision Program Launched to Prevent HIV Transmission 2Health News:Ruth's Hospitality Group Inc. donates Broad Street building to Tulane 2Health News:Ruth's Hospitality Group Inc. donates Broad Street building to Tulane 3Health News:Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award 2Health News:Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award 3Health News:Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award 4Health News:Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award 5Health News:Duane Reade Dispenses a Large Dose of Marketing, as it Strengthens its Hometown Connection 2Health News:Duane Reade Dispenses a Large Dose of Marketing, as it Strengthens its Hometown Connection 3Health News:Pederson Immigration Law Group Announces 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 2Health News:Earvin 'Magic' Johnson and the Magic Johnson Foundation Give Students their 'Blueprint for Success' at Annual Leadership Conference 2
(Date:5/6/2015)...  Galmed Pharmaceuticals Ltd. (Nasdaq: GLMD ) ("Galmed"), ... commercialization of a once-daily, oral therapy for the treatment ... it will host a conference call and webcast on ... period ended March 31, 2015 and to provide an ... program for aramchol. Conference Call & ...
(Date:5/6/2015)... GERMANTOWN, Md. , May 6, 2015 ... neural stem cell technology to develop small molecule and ... the appointment of Jonathan Lloyd Jones to ... th . Mr. Lloyd Jones ... of corporate finance and business development experience.   Most recently, ...
(Date:5/6/2015)... 6, 2015  Juniper Pharmaceuticals, Inc. (Nasdaq: JNP ... for the three-month period ended March 31, 2015. First quarter ... million, an increase of 19% as compared to $7.0 ... Product revenues increased 41% year-over-year, enabled by the return ... Merck Serono in the fourth quarter of 2014; ...
Breaking Medicine Technology:Galmed Pharmaceuticals First Quarter 2015 Conference Call and Webcast Scheduled for Wednesday, May 13, 2015 2Galmed Pharmaceuticals First Quarter 2015 Conference Call and Webcast Scheduled for Wednesday, May 13, 2015 3Neuralstem Appoints Jonathan Lloyd Jones as Chief Financial Officer 2Neuralstem Appoints Jonathan Lloyd Jones as Chief Financial Officer 3Neuralstem Appoints Jonathan Lloyd Jones as Chief Financial Officer 4Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 2Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 3Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 4Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 5Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 6Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 7Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 8Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 9Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 10Juniper Pharmaceuticals Reports First Quarter 2015 Financial Results 11
... 26, 2007,/PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, Inc. , ... announced that,the two-year data from its European ... ("Vascular Wrap(TM)"),will be presented today at a ... the safety and efficacy of the Vascular,Wrap(TM) ...
... cord and other central,nervous system transplants possible, BOSTON, ... Eye Research Institute, an affiliate of Harvard Medical,School, ... into the adult central nervous system. The,study found ... induced by,stem cells) has the ability to break ...
Cached Medicine Technology:Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 2Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 3Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 4Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 5Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 6Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 7Schepens Scientists Identify Key to Integrating Transplanted Nerve,Cells Into Injured Tissue 2Schepens Scientists Identify Key to Integrating Transplanted Nerve,Cells Into Injured Tissue 3
20 foot distance 22-1/2" X 11-1/2". This test for illiterate patients has HOTV letters on one side and Allen figures on the other....
McIntyre-binkhorst irrigating cannula....
Binkhorst, length 35 mm....
Army navy retractor set....
Medicine Products: