Navigation Links
Immune system pathway identified to fight allergens, asthma
Date:5/7/2008

PITTSBURGH, May 7 For the first time, researchers from the University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction. Targeting these elements could result in more effective drugs to treat allergic disorders and asthma, according to a study reported in the May edition of the journal Nature Medicine.

Dendritic cells are vital to immune response in that they recognize, capture and introduce threatening organisms to T lymphocytesother immune cells that secrete potent proteins called cytokines that surround and destroy the invaders. However, the Pittsburgh teams study goes further to illuminate a pathway that allergens use to act directly on dendritic cells to propel differentiation into the T lymphocytes that fight back.

We now have identified a molecule, c-Kit, that is central to the process of allergic response, said Anuradha Ray, Ph.D., co-corresponding author and professor of medicine and immunology in the Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine. We show that genes encoding for c-Kit and the cytokine interleukin 6 (IL-6) are significantly activated when allergens are present, but c-Kit is the very first molecule that gets triggered.

Interactions between viruses and bacteria and molecular steps that initiate the immune defense have remained largely unknown. Using cells cultured from c-Kit mutant mice, Dr. Ray, her husband and co-corresponding author Prabir Ray, Ph.D., and their colleagues studied molecular reactions to assaults by cholera toxin and a standard allergen, house dust mites. In addition to c-Kit and IL-6, they found effects on stem cell factor and Jagged-2immune system molecules that are parts of the activation process.

We have known the T-cell side of the story for many years, and we know that dendritic cells are important, but what we did
'/>"/>

Contact: Michele Baum
BaumMD@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... September 17, 2014 Kamut International is ... a key ingredient in Michael Angelo’s new “Made With ... new fully organic lasagna ready made, frozen meal. Michael ... pastas and these new products align well with Kamut ... all KAMUT® Brand wheat must be grown certified organic. ...
(Date:9/17/2014)... Promising new research published in the Journal ... the potential ability of ketones to support brain function ... study shows that brain hypometabolism associated with ... glucose uptake and/or utilization, and results suggest that increasing ... study, by the Research Center on Aging and Department ...
(Date:9/17/2014)... Right now no one can say whether yoga ... in a new article in the Journal of ... from scores of people with the condition who practice ... can be a substantial help, but it sometimes carries ... hatha yoga for bipolar disorder," said lead author Lisa ...
(Date:9/17/2014)... Fresh off their High Times Cannabis ... support of The Silver Tour, an educational non-profit effort ... benefits of medical marijuana. , Florida Buds, a Florida ... marijuana dispensary and treatment center, donated $1,000.00 to ... launch a statewide radio campaign in advance of Election ...
(Date:9/17/2014)... DMG Productions announces the upcoming airing ... broadcast on Wednesday, September 24, 2014 at 7:30 ... episode, Innovations will go behind the scenes to ... each client the opportunity to achieve the highest ... principles of Care, Compassion, and Commitment. , Audiences ...
Breaking Medicine News(10 mins):Health News:KAMUT® Brand Wheat Delivers a High Quality Ingredient and Authentic Italian Taste for Michael Angelo’s New Ready-Made Meals featuring Organic Ingredients 2Health News:Journal of Alzheimer's Disease Publishes New Study Suggesting Ketones have Potential to Compensate for Brain Energy Deficit 2Health News:Journal of Alzheimer's Disease Publishes New Study Suggesting Ketones have Potential to Compensate for Brain Energy Deficit 3Health News:Survey finds benefits, risks of yoga for bipolar disorder 2Health News:Survey finds benefits, risks of yoga for bipolar disorder 3Health News:Florida Buds Supports Silver Tour 2Health News:Innovations to Explore Substance Abuse and Mental Health in Upcoming Episode Airing Wednesday, September 24, 2014 via Discovery Channel. 2
... becomes a job search engine with the functionality of a job board. ... ... the current economic woes, employment sites are experiencing an increase in the ... for new job openings, Fresho has changed its business concept from a ...
... Howard G. Smith,announces that a class action lawsuit has ... District of New Jersey against PharmaNet Development,Group, Inc. ("PharmaNet" ... behalf of all,persons who purchased or otherwise acquired the ... 2008. The complaint alleges that the Company,and certain of ...
... the,health insurance industry now have a dedicated community ... education coursework, and ensure best,practice application of research ... "We were looking for an ... there was no dedicated group for the health ...
... women need more culturally targeted information, study finds , , ... almost six times more likely than white women to ... breast cancer treatment, a new report says. , Researchers ... that despite being just as involved with their doctor ...
... Nov. 21 Album Creative Studios, Inc., a full-service brand ... for small businesses. , , ... services, and tailored them to small businesses with a very ... Creative , founded in 2002, combines experience and proven brand-building ...
... Health Science Center at Houston will launch a new ... geriatrics training for physicians through a prestigious $2 million ... million in matching funds., "This will allow us to ... junior medical student to practicing physicians. With the reach ...
Cached Medicine News:Health News:Fresho.com Adapts As The Online Recruiting Market Heats Up 2Health News:Law Offices of Howard G. Smith Announces Class Action Lawsuit on Behalf of Investors of PharmaNet Development Group, Inc. 2Health News:Society of Insurance Research and Fletcher/CSI Create First Forum for Research Professionals in the Health Insurance Industry 2Health News:Society of Insurance Research and Fletcher/CSI Create First Forum for Research Professionals in the Health Insurance Industry 3Health News:Album Creative Studios Tailors Big Brand Marketing For Small Businesses 2Health News:UT Houston launches geriatric training with $3.25 million in grant, matching funds 2Health News:UT Houston launches geriatric training with $3.25 million in grant, matching funds 3Health News:UT Houston launches geriatric training with $3.25 million in grant, matching funds 4
(Date:9/17/2014)... 17 2014 IBM (NYSE: IBM ) ... IBM technical computing and storage technology to accelerate ... These services deliver critically important information to help ... unique cancer, which could lead to better health ... in general. Today, optimal cancer care ...
(Date:9/17/2014)... , Switzerland , September 17, ... Debiopharm Group ™ , is proud to congratulate Biocartis ... instrument. Debiopharm Diagnostics is a long-time investor in ... Idylla ™ Biocartis, fully automated, real-time ... offer physicians fast and easy access to clinical ...
(Date:9/16/2014)... Sept. 16, 2014  ROX Medical today presented ... multi-center, prospective, randomized, controlled, blinded endpoint study of ... hypertension. The CONTROL-HTN trial, NCT01642498, evaluated the safety and ... connection between a central artery and vein in ... hypertension. The primary outcomes are reduction of blood ...
Breaking Medicine Technology:Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 2Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 3Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 4Debiopharm Diagnostics Portfolio Company Biocartis Ships its First Idylla Instrument 2ROX Medical presents positive data for CONTROL-HTN resistant hypertension trial 2
... Health Solutions, Inc. (NYSE: MHS ) will webcast its Annual Meeting ...  The presentations by David B. Snow Jr. , chairman and CEO, and ... , , ... Investor Relations section at www.medco.com/investor . The webcast will be available for ...
... May, AllerAir is supporting Multiple Chemical Sensitivities and Chemical Injury ...   , , , ... chemical awareness tips and a $50.00 gift certificate available via ... articles will be dedicated to Multiple Chemical Sensitivities ...
Cached Medicine Technology:Medco Announces Webcast for Annual Meeting of Shareholders 2Multiple Chemical Sensitivities Are Real 2Multiple Chemical Sensitivities Are Real 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: