Navigation Links
Immune system may guide chemotherapy for breast cancer
Date:4/2/2011

ORLANDO, Fla. A study published in Cancer Discovery, the newest journal of the American Association for Cancer Research, debuting here at the AACR 102nd Annual Meeting 2011, held April 2-6, showed how evaluating the immune response in the tumor microenvironment may help researchers better target therapy in breast cancer.

Researchers at the University of California, San Francisco, demonstrated that the level of macrophages and CD8+ T-cells, two key components of the human immune system, can help predict recurrence and overall survival. New biologic-targeted therapies impairing macrophage recruitment into tumors show promising results in preclinical studies.

"Phase I clinical trials are blunt instruments because their goal is often limited to determining a safe dose for a new drug," said Lisa Coussens, Ph.D., professor in the department of pathology at the University of California, San Francisco. "Using preclinical transgenic mouse models of cancer development, scientists cannot only help determine a safe dose for a new drug, but also identify biomarkers indicative of the biological response of the new drug. Identification of relevant biomarkers can then be translated to clinical studies and help to determine which patients are or are not responding to the drug."

For the current study, Coussens and colleagues tested the effect of PLX3397, a compound currently in a Phase I clinical trial and developed by Plexxikon Inc., which inhibits colony stimulating factor 1 receptor kinase activity, and thereby blocks macrophage recruitment into tumors.

Blocking macrophage recruitment, in combination with paclitaxel, slowed primary tumor development and reduced metastasis in the laboratory animals that were studied. Moreover, these measureable improvements were accompanied by a decreased tumor vessel density and the increased presence of immune cells with anti-tumor properties in the tumors of these mice.

"Understanding more about this tumor microenvironment response can help enhance the effectiveness of chemotherapy," said Coussens.

Coussens and colleagues are working with Plexxikon to further test PLX3397 in other cancers, including mesothelioma, where blocking macrophage recruitment also shows promise.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. NIH investigators find link between DNA damage and immune response
2. Case Western Reserve receives $1.6M to study tumor cells and immune cell detection
3. 2nd International Conference on Immune Tolerance
4. Stress May Alter Gut Bacteria to Hinder Immune System
5. Penn researchers uncover novel immune therapy for pancreatic cancer
6. Stress affects the balance of bacteria in the gut and immune response
7. Newly identified cell population key to immune response
8. Gene that regulates immune system linked to preeclampsia
9. Border patrol: Immune cells protect body from invaders, according to Penn study
10. Breast cancer cells outsmart the immune system and thrive
11. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... ... While a significant number of women and men with eating disorders report a ... that best predicts the development of an eating disorder. , At the ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... excited to share this important news! AHCC and the Home Health and Hospice ... Clinic, CMS' designee for official ICD coding guidance and clarifications, to address concerns ...
(Date:2/8/2016)... ... February 08, 2016 , ... The schedule is ... this country. The AutismOne 2016 Conference, which is being held May 25-29 at the ... hear elsewhere about helpful interventions and causes of chronic illness in children. , Very ...
(Date:2/7/2016)... Dallas, Texas (PRWEB) , ... February 07, 2016 ... ... its new MyDecision™ program. MyDecision™ empowers employers and organizations with the tools and ... , MyDecision™ combines three elements to cut the cost of providing employee healthcare ...
(Date:2/6/2016)... ... February 06, 2016 , ... With the FCPX LUT: Summer ... grades to their footage. A LUT is a Lookup Table that contains a mathematical ... color indicated by the table. By manipulating each pixel, LUT's can change each color ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016   HighPoint Solutions today ... (NRG),s pharmacovigilance technology services division.  NRG is a ... an Oracle Argus Specialized partner, providing drug safety ... companies. --> --> ... sciences capabilities and provides a global scale and ...
(Date:2/8/2016)... part of a major growth and expansion initiative, Dune Medical ... Chmura as President of Dune Inc., its U.S. division. ... experience in the medical device space will play a large ... --> --> In her new ... and operational functions in the U.S. She is tasked with ...
(Date:2/8/2016)... Feb. 8, 2016 Velano Vascular, a medical ... hospitalized patients and their practitioners, announced today that the ... Velano will use the proceeds from this financing, an ... in January 2015, to support the development and commercialization ... pediatric populations. Philadelphia , ...
Breaking Medicine Technology: