Navigation Links
Immune system may guide chemotherapy for breast cancer
Date:4/2/2011

ORLANDO, Fla. A study published in Cancer Discovery, the newest journal of the American Association for Cancer Research, debuting here at the AACR 102nd Annual Meeting 2011, held April 2-6, showed how evaluating the immune response in the tumor microenvironment may help researchers better target therapy in breast cancer.

Researchers at the University of California, San Francisco, demonstrated that the level of macrophages and CD8+ T-cells, two key components of the human immune system, can help predict recurrence and overall survival. New biologic-targeted therapies impairing macrophage recruitment into tumors show promising results in preclinical studies.

"Phase I clinical trials are blunt instruments because their goal is often limited to determining a safe dose for a new drug," said Lisa Coussens, Ph.D., professor in the department of pathology at the University of California, San Francisco. "Using preclinical transgenic mouse models of cancer development, scientists cannot only help determine a safe dose for a new drug, but also identify biomarkers indicative of the biological response of the new drug. Identification of relevant biomarkers can then be translated to clinical studies and help to determine which patients are or are not responding to the drug."

For the current study, Coussens and colleagues tested the effect of PLX3397, a compound currently in a Phase I clinical trial and developed by Plexxikon Inc., which inhibits colony stimulating factor 1 receptor kinase activity, and thereby blocks macrophage recruitment into tumors.

Blocking macrophage recruitment, in combination with paclitaxel, slowed primary tumor development and reduced metastasis in the laboratory animals that were studied. Moreover, these measureable improvements were accompanied by a decreased tumor vessel density and the increased presence of immune cells with anti-tumor properties in the tumors of these mice.

"Understanding more about this tumor microenvironment response can help enhance the effectiveness of chemotherapy," said Coussens.

Coussens and colleagues are working with Plexxikon to further test PLX3397 in other cancers, including mesothelioma, where blocking macrophage recruitment also shows promise.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. NIH investigators find link between DNA damage and immune response
2. Case Western Reserve receives $1.6M to study tumor cells and immune cell detection
3. 2nd International Conference on Immune Tolerance
4. Stress May Alter Gut Bacteria to Hinder Immune System
5. Penn researchers uncover novel immune therapy for pancreatic cancer
6. Stress affects the balance of bacteria in the gut and immune response
7. Newly identified cell population key to immune response
8. Gene that regulates immune system linked to preeclampsia
9. Border patrol: Immune cells protect body from invaders, according to Penn study
10. Breast cancer cells outsmart the immune system and thrive
11. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... 28, 2016 , ... Amada Senior Care, premier provider of non-medical in-home care ... its San Antonio West location. Prior to entering the senior care industry, Amada franchise ... of Amada San Antonio West will take place on Friday, April 29th. ...
(Date:4/28/2016)... AZ (PRWEB) , ... April ... ... the AnzuMedical™ Knowledge Sharing and Collaboration Platform™ , today announced a ... platform will provide efficient access to medical knowledge, educational resources, and a ...
(Date:4/28/2016)... ... April 28, 2016 , ... April, ... a Top Doc in Physical Medicine and Rehabilitation by Philadelphia Magazine. , Philadelphia ... Ltd. by randomly surveying physicians and medical leadership across the country. These select ...
(Date:4/28/2016)... ... 28, 2016 , ... SyncDog, Inc. , the leading ... mobility workstation suite, SentinelSecure™, at MobileIron’s 6th annual Mobile First Conference in San ... MobileIron’s 6th Mobile First Conference and will feature immersive training, collaboration, and connections ...
(Date:4/28/2016)... ... ... The Aging in Motion Coalition (AIM) has announced the Centers for ... recognition for separate reporting and data collection. The code, M62.84, will be available for ... a combination of low muscle mass and weakness in older adults that causes functional ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , April 27, 2016  Bayer Animal Health ... senior from the University of Florida College of ... Bayer Excellence in Communication Award (BECA). Brittany was ... were awarded a total of $70,000 in scholarship ... four years, Bayer has provided a total of ...
(Date:4/27/2016)... , April 27, 2016 ... to reach USD 2.06 billion by 2022, according ... Inc. Increasing consumer awareness towards a healthy lifestyle ... next seven years.      (Logo: ... intake coupled with rising health treatment expenditure has ...
(Date:4/26/2016)... 27, 2016 Research and Markets ... Diagnostics Market 2016-2020" report to their offering. ... global molecular diagnostics market is projected to grow at ... Molecular diagnostics is a technique that involves measurement ... level to detect changes in biochemical pathways. The aim ...
Breaking Medicine Technology: