Navigation Links
Immune system kick-started in moist nasal lining in sinusitis, asthma and colds
Date:4/29/2008

Scientists at Johns Hopkins have outlined a new path for potential therapies to combat inflammation associated with sinusitis and asthma based on a new understanding of the bodys earliest immune response in the nose and sinus cavities.

Researchers say their findings, to be published in the May edition of the Journal of Allergy and Clinical Immunology, are the first evidence describing how viral agents, such as the rhinovirus responsible for the common cold, can kick start the bodys mobilization of immune white blood cells in the moist, mucous membrane lining of the nasal passages.

While such responses are key to maintain health in the face of pathogens, they can also become a source of illness due to resulting inflammation. This can lead to potentially life-long problems, including tissue swelling, nasal polyp formation, sneezing, stuffy and runny nose, sore throat, cough, headache, chills, fever and difficulty breathing.

Thus, blocking these reactions, the researchers point out, could interrupt the cascade of feel-awful symptoms that ensue.

The focus of the study is B7-related proteins, called B7 homologs, which trip white blood cell response in a pathogen attack.

Using purified cold virus and its genetic material as bait, the scientists found that production of two B7 homologs spiked in response: Levels of B7-H1 jumped almost ninefold and levels of B7-DC tripled.

Until now, says senior study investigator Jean Kim, M.D., Ph.D., viruses were known to reside in and infect the physical epithelium, invading surface membrane cells and revving up the immune systems main blood cell defenses, but no one knew the major steps involved in or precisely how this immune response was triggered.

The inside surface of our nose and sinuses is much more than a protective cover, and we have good scientific evidence to show that epithelial cells on these mucosal membranes are very powerful mediators - middl
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Immune-Boosting Lung Cancer Therapy Shows Promise
2. Phone counseling improves quality of life, immune systems of cervical cancer survivors
3. Immunotherapy: enlisting the immune system to fight cancer
4. Embryonic stem cells could help to overcome immune rejection problems
5. Manipulating the immune system like a parasite
6. Eating Less May Hinder Immune System
7. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
8. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
9. New protein discovery helps researchers understand autoimmune diseases
10. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
11. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 1% for the Planet , one ... that Kate Williams, the network’s Director of Partnerships, will step ... Williams has been part of 1% for the Planet since ... of the Northern Forest Canoe Trail, a 1% for the ... the stewardship of and advocacy for the outdoors, a commitment ...
(Date:4/20/2015)... "It's so hard to put into words what ... really thought I would just be paying for funerals ... discovered is this need that other baby loss families ... and walk through this journey together," says Ramsey Keller ... from these families than I could ever hope to ...
(Date:4/20/2015)... 2015 Northern Westchester Hospital ... Services introduced their new 5-star “Patient Experience” rating system ... Healthcare Providers and Systems) survey of hospital patient treatment ... experiences during a recent hospital stay. , ... through June 30, 2014 can be reviewed online ...
(Date:4/20/2015)... The president of Medicine & Science at Cancer ... magazine argues the FDA’s recent approval of olaparib (Lynparza) ... restrictive and should be offered to many more patients. ... M.D., says clinical trial evidence indicates that some women ... positive for a BRCA mutation may also respond to ...
(Date:4/20/2015)... MS (PRWEB) April 20, 2015 Medical ... North Sunflower Medical Center in Ruleville, Miss., to help ... installing four welloStations™ throughout its facilities. The ... for employees, patients, suppliers and others as they enter ... several products and procedural applications offered by MGI to ...
Breaking Medicine News(10 mins):Health News:1% for the Planet Announces New CEO 2Health News:1% for the Planet Announces New CEO 3Health News:3 Years Later, Ramsey Keller Memorial Founder Reflects on Baby Loss, Giving Back by Paying for Infant Funerals in Montana and Receiving More Than She Will Ever Give 2Health News:3 Years Later, Ramsey Keller Memorial Founder Reflects on Baby Loss, Giving Back by Paying for Infant Funerals in Montana and Receiving More Than She Will Ever Give 3Health News:Northern Westchester Hospital Named a 5-Star Hospital In Medicare's Patient Satisfaction Rating 2Health News:Northern Westchester Hospital Named a 5-Star Hospital In Medicare's Patient Satisfaction Rating 3Health News:Recent FDA Approval of Ovarian Cancer Treatment Is Too Restrictive, Specialist in Gynecologic Malignancies Says in OncLive® Article 2Health News:Medical Grade Innovations Helps North Sunflower Medical Center Reduce Infection Spread with the welloStation™ 2Health News:Medical Grade Innovations Helps North Sunflower Medical Center Reduce Infection Spread with the welloStation™ 3Health News:Medical Grade Innovations Helps North Sunflower Medical Center Reduce Infection Spread with the welloStation™ 4
... pneumonia at the Sipahijala wildlife sanctuary-cum-zoo in Tripura, officials said ... from a bout of pneumonia as the state was lashed ... ,"Inadequate sheds and enclosures in the zoo had forced ... sky while it was raining heavily. The deaths occurred in ...
... the rise in the world. There is also a rise ... of alcoholism among women says that in women cognitive problems ... ,Women drinkers are subject to physical changes in the brain ... a senior scientist at the research institute RTI at the ...
... to the perils of imported eye cosmetics//. ,The officials ... makeup products known as kajal, kohl and surma which are ... used traditionally by ladies to beautify the eyes are believed ... Lead poisoning can lead to cognitive and behavioral ...
... simple scoring system based on five medical factors accurately predicts ... at highest// risk of dying. ,The scoring system, ... Center surgeons, has been validated in a new study of ... patient's weight, gender, age, blood pressure and risk of developing ...
... three sexually active older adults infected with HIV has unprotected ... survey of 260 HIV-positive older adults found that of those ... a relationship. ,AIDs cases among the over-50 crowd ... Control and Prevention, they will account for half of all ...
... women, according to researchers at the University of Minnesota ... a recent issue of Preventive Medicine found no strong ... In addition, self-weighing daily, rather than once every week ... (BMI) levels in women 40 years or older. ...
Cached Medicine News:Health News:Alcoholism Develops Cognitive Problems in Women 2Health News:Simple System Accurately Predicts Weight-loss Surgery Risk 2Health News:Simple System Accurately Predicts Weight-loss Surgery Risk 3Health News:One-Third of Sexually Active Older Adults With HIV/AIDs Has Unprotected Sex 2
(Date:4/20/2015)... , April 20, 2015 The preclinical contract ... pharmacokinetic testing of drugs and safety testing of medical devices, ... present at this week,s workshop " Drug Transporters in ADME: ... Baltimore, MD . The title of Dr. Hidalgo,s talk ... of a session entitled "Transporter Tools of the Future." ...
(Date:4/20/2015)...  Teradata (NYSE: TDC ), the ... company, today announced the newest analytic innovation ... Life Sciences helps organizations integrate and analyze data ... (RED), clinical analysis, Real-World Evidence (RWE), and finance. ... can benefit by bringing safer, more effective treatments ...
(Date:4/20/2015)... April 20, 2015   Gateway Rehab ... Training Institute today expanded its Naloxone: Increasing Access, ... A $50,000 grant from the Staunton Farm ... possible.  The yearlong research project, ... and their family members upon completion of treatment ...
Breaking Medicine Technology:Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2Teradata Delivers Big Analytics Innovation for Life Sciences 2Teradata Delivers Big Analytics Innovation for Life Sciences 3Teradata Delivers Big Analytics Innovation for Life Sciences 4Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 2Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 3
... Presented at American Academy of Dermatology Summer ... NeoStrata today announced,findings from an ongoing 12-week ... applied LCD (coal tar) solution (Psorent(TM)) versus,calcipotriol ... psoriasis.,Specifically, results of an interim analysis reveal ...
... 30 An overwhelming number of,Americans with memory ... their,doctors despite visits within the past six months, ... participants in the Alzheimer,s Foundation of,America (AFA) National ... the results at a poster session at the ...
Cached Medicine Technology:Study Reveals Novel LCD Solution Provides Significant Benefits Versus Calcipotriol In Treatment Of Moderate Psoriasis 2Study Reveals Novel LCD Solution Provides Significant Benefits Versus Calcipotriol In Treatment Of Moderate Psoriasis 3Alzheimer's Foundation of America Survey: Americans With Memory Concerns Fall Short of Talking to Doctors 2Alzheimer's Foundation of America Survey: Americans With Memory Concerns Fall Short of Talking to Doctors 3
ELISA kit for the quantitative determination of autoantibodies to IA-2 in serum...
Inquire...
Bench Top Class I Containment Cabinet Personnel Protection...
Inquire...
Medicine Products: