Navigation Links
Immune system kick-started in moist nasal lining in sinusitis, asthma and colds
Date:4/29/2008

Scientists at Johns Hopkins have outlined a new path for potential therapies to combat inflammation associated with sinusitis and asthma based on a new understanding of the bodys earliest immune response in the nose and sinus cavities.

Researchers say their findings, to be published in the May edition of the Journal of Allergy and Clinical Immunology, are the first evidence describing how viral agents, such as the rhinovirus responsible for the common cold, can kick start the bodys mobilization of immune white blood cells in the moist, mucous membrane lining of the nasal passages.

While such responses are key to maintain health in the face of pathogens, they can also become a source of illness due to resulting inflammation. This can lead to potentially life-long problems, including tissue swelling, nasal polyp formation, sneezing, stuffy and runny nose, sore throat, cough, headache, chills, fever and difficulty breathing.

Thus, blocking these reactions, the researchers point out, could interrupt the cascade of feel-awful symptoms that ensue.

The focus of the study is B7-related proteins, called B7 homologs, which trip white blood cell response in a pathogen attack.

Using purified cold virus and its genetic material as bait, the scientists found that production of two B7 homologs spiked in response: Levels of B7-H1 jumped almost ninefold and levels of B7-DC tripled.

Until now, says senior study investigator Jean Kim, M.D., Ph.D., viruses were known to reside in and infect the physical epithelium, invading surface membrane cells and revving up the immune systems main blood cell defenses, but no one knew the major steps involved in or precisely how this immune response was triggered.

The inside surface of our nose and sinuses is much more than a protective cover, and we have good scientific evidence to show that epithelial cells on these mucosal membranes are very powerful mediators - middl
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Immune-Boosting Lung Cancer Therapy Shows Promise
2. Phone counseling improves quality of life, immune systems of cervical cancer survivors
3. Immunotherapy: enlisting the immune system to fight cancer
4. Embryonic stem cells could help to overcome immune rejection problems
5. Manipulating the immune system like a parasite
6. Eating Less May Hinder Immune System
7. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
8. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
9. New protein discovery helps researchers understand autoimmune diseases
10. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
11. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... (April 21, 2014) -- A group of scientists ... and the Sanders-Brown Center on Aging has found ... and neuropsychological function in Parkinson,s disease (PD). ... , the study, which assessed cognitive function in ... the dopamine replacement therapy commonly used to treat ...
(Date:4/18/2014)... memories? How did it make you feel? According to ... experience, such as how sad you were or how ... when you can,t stop thinking about it. , ... context of the memories, rather than how you felt, ... the negative effects of these memories, a new study ...
(Date:4/18/2014)... scientists could lead to potential new treatments for breaking ... , Fibrosis, or scarring, is a hallmark of ... lungs can lead to serious organ damage and, in ... options centers on findings made by Swati Bhattacharyya, PhD, ... that a specific protein plays in promoting fibrosis. ...
(Date:4/17/2014)... One of the most popular vaccine brands for children ... may be overlooking some cost factors when choosing vaccines, ... expensive option, according to a new study by University ... administer can be driven by numerous factors," says Sheldon ... professor of computer science and of mathematics at the ...
(Date:4/17/2014)... In a review published in the April issue of ... The Feinstein Institute for Medical Research, says it,s time ... approach to treating sepsis, which kills millions ... Sepsis occurs when molecules released into the bloodstream to ... body. Inflammation is necessary for maintaining good health ...
Breaking Medicine News(10 mins):Health News:Treating depression in PD patients: New research 2Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:New clues on tissue scarring in scleroderma 2Health News:Study recalculates costs of combination vaccines 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2
... SPRING, Md., Sept. 30 The U.S. Food and ... draft guidance for industry on Risk Evaluation and Mitigation ... or biologics. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ) ... of 2007 (FDAAA) granted the FDA the authority to ...
... , MINNEAPOLIS, Sept. 30 Polaroid ® announces ... support National Breast Cancer Awareness Month beginning October 1st. A ... donated to The Breast Cancer Research Foundation (BCRF). , The ... the third year Polaroid has partnered with BCRF to create awareness ...
... Drug companies are sprinting ahead in a race against the ... the H1N1 influenza virus before cooler weather ushers in the ... issue of Chemical & Engineering News , ACS, weekly ... drugs for flu infections. C&EN senior correspondent Ann Thayer ...
... other types of cardiovascular disease , WEDNESDAY, Sept. 30 ... help protect against heart attacks and other cardiovascular disease, ... guard against the development of heart failure. , Heart ... treatment and lifestyle people are living longer with it. ...
... ... directory gives students insight into acupuncture’s ancient traditions and thriving modern health careers. ... ... health and alternative medicine directory, recently launched The Acupuncture Career and School ...
... ORLEANS, Sept. 30 Pan-American Life Insurance Group (PALIG), ... today that the company has filed a request for ... , "Pan-American Life,s 98-year history and the Group,s ... in this business development decision. Expansion into Costa Rica ...
Cached Medicine News:Health News:FDA Issues Draft Guidance on Risk Evaluation and Mitigation Strategies 2Health News:Polaroid(R) and The Breast Cancer Research Foundation(R) Print Pink 2Health News:Study Finds Fish Won't Prevent Heart Failure 2Health News:Study Finds Fish Won't Prevent Heart Failure 3Health News:Acupuncture Career Guide Launches on Natural Healers 2Health News:Acupuncture Career Guide Launches on Natural Healers 3Health News:Pan-American Life Insurance Group Plans to Complete Coverage in Central America With Entry Into Costa Rica; Company Files Request for Authorization 2
(Date:1/15/2014)... GRAND RAPIDS, Mich. , Jan. 15, 2014 As ... of the flu virus, select Meijer pharmacies in ... and strep throat to eligible patients, enabling Meijer pharmacists to ... under strict protocol set by a physician participating in the ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... condition to the announced tender offer for all of the outstanding ... result of the waiver, the transaction is no longer conditional on ... January 24, 2014 following the currently scheduled expiration time, subject to ...
(Date:1/15/2014)... is very pleased to announce the appointment of Mr. ... Mark was promoted from his current role of Chief Operating ... in Massachusetts , Mississippi ... 2012 with 20+ years of broad-based operations, sales, engineering and ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
... /PRNewswire/ -- PRA International, a leading Clinical Research ... during the 8th Annual Partnerships in Clinical Trials 2009 to ... Trade Centre in Rotterdam, The Netherlands. PRA operational and ... exhibiting at booth number 32. , On 4 November, PRA,s ...
... Shire plc (LSE: SHP, NASDAQ:,SHPGY) the global specialty biopharmaceutical company, announces results for,the three months to September 30, 2009. , , ... ... sales ... Product sales from core products(2) $532 ...
Cached Medicine Technology:PRA International Experts Present a Session at the 8th Annual Partnerships in Clinical Trials 2009 2Shire Continues to Deliver Excellent Growth From Core Products 2Shire Continues to Deliver Excellent Growth From Core Products 3Shire Continues to Deliver Excellent Growth From Core Products 4Shire Continues to Deliver Excellent Growth From Core Products 5Shire Continues to Deliver Excellent Growth From Core Products 6Shire Continues to Deliver Excellent Growth From Core Products 7Shire Continues to Deliver Excellent Growth From Core Products 8Shire Continues to Deliver Excellent Growth From Core Products 9Shire Continues to Deliver Excellent Growth From Core Products 10Shire Continues to Deliver Excellent Growth From Core Products 11Shire Continues to Deliver Excellent Growth From Core Products 12Shire Continues to Deliver Excellent Growth From Core Products 13Shire Continues to Deliver Excellent Growth From Core Products 14Shire Continues to Deliver Excellent Growth From Core Products 15Shire Continues to Deliver Excellent Growth From Core Products 16Shire Continues to Deliver Excellent Growth From Core Products 17Shire Continues to Deliver Excellent Growth From Core Products 18Shire Continues to Deliver Excellent Growth From Core Products 19Shire Continues to Deliver Excellent Growth From Core Products 20Shire Continues to Deliver Excellent Growth From Core Products 21Shire Continues to Deliver Excellent Growth From Core Products 22Shire Continues to Deliver Excellent Growth From Core Products 23Shire Continues to Deliver Excellent Growth From Core Products 24Shire Continues to Deliver Excellent Growth From Core Products 25Shire Continues to Deliver Excellent Growth From Core Products 26Shire Continues to Deliver Excellent Growth From Core Products 27Shire Continues to Deliver Excellent Growth From Core Products 28Shire Continues to Deliver Excellent Growth From Core Products 29Shire Continues to Deliver Excellent Growth From Core Products 30Shire Continues to Deliver Excellent Growth From Core Products 31Shire Continues to Deliver Excellent Growth From Core Products 32Shire Continues to Deliver Excellent Growth From Core Products 33
... orthosis is designed for the management ... diaphyseal fractures. The lightweight anatomical design ... compression for optimal control of humeral ... both the shoulder and elbow joints. ...
Controls humeral segments through soft tissue compression while allowing for full range of elbow motion...
... RCAI Plantar Fasciitis Night Splint is indicated ... Achilles tendonitis. It is economical and easy ... assist straps for controlled dorsiflexion, limiting nightly ... and Achilles tendon. This feature permits flexibility ...
Comfortably positions the affected foot at 90 to provide continuous and effective stretching of the plantar fascia and Achilles Tendon...
Medicine Products: