Navigation Links
Immune system kick-started in moist nasal lining in sinusitis, asthma and colds
Date:4/29/2008

Scientists at Johns Hopkins have outlined a new path for potential therapies to combat inflammation associated with sinusitis and asthma based on a new understanding of the bodys earliest immune response in the nose and sinus cavities.

Researchers say their findings, to be published in the May edition of the Journal of Allergy and Clinical Immunology, are the first evidence describing how viral agents, such as the rhinovirus responsible for the common cold, can kick start the bodys mobilization of immune white blood cells in the moist, mucous membrane lining of the nasal passages.

While such responses are key to maintain health in the face of pathogens, they can also become a source of illness due to resulting inflammation. This can lead to potentially life-long problems, including tissue swelling, nasal polyp formation, sneezing, stuffy and runny nose, sore throat, cough, headache, chills, fever and difficulty breathing.

Thus, blocking these reactions, the researchers point out, could interrupt the cascade of feel-awful symptoms that ensue.

The focus of the study is B7-related proteins, called B7 homologs, which trip white blood cell response in a pathogen attack.

Using purified cold virus and its genetic material as bait, the scientists found that production of two B7 homologs spiked in response: Levels of B7-H1 jumped almost ninefold and levels of B7-DC tripled.

Until now, says senior study investigator Jean Kim, M.D., Ph.D., viruses were known to reside in and infect the physical epithelium, invading surface membrane cells and revving up the immune systems main blood cell defenses, but no one knew the major steps involved in or precisely how this immune response was triggered.

The inside surface of our nose and sinuses is much more than a protective cover, and we have good scientific evidence to show that epithelial cells on these mucosal membranes are very powerful mediators - middl
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Immune-Boosting Lung Cancer Therapy Shows Promise
2. Phone counseling improves quality of life, immune systems of cervical cancer survivors
3. Immunotherapy: enlisting the immune system to fight cancer
4. Embryonic stem cells could help to overcome immune rejection problems
5. Manipulating the immune system like a parasite
6. Eating Less May Hinder Immune System
7. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
8. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
9. New protein discovery helps researchers understand autoimmune diseases
10. MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
11. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... (PRWEB) June 02, 2015 Highly qualified dental ... a plan to drive prolific change in the dental tourism ... TDC Team Dental Clinic offers a full range of ... management structure for dental tourism. , Partnered with a ... is committed to advancing dentistry and has earned a reputation ...
(Date:6/2/2015)... UCLA Health and Exer have completed ... and expand urgent care services in Los Angeles County. ... University of California Board of Regents and the Exer ... Health to purchase a minority share of four existing ... Park and Northridge and creates opportunity to grow and ...
(Date:6/2/2015)... Gujarat, India (PRWEB) June 02, 2015 ... finalist in the 2015 Microsoft Worldwide Small and Midsized ... global field of top Microsoft partners for demonstrating excellence ... Microsoft technology. , “This comes as no surprise ... are recognized third year consecutively at worldwide level by ...
(Date:6/2/2015)... TX, USA (PRWEB) June 02, 2015 ... microsystems, is deploying its growth strategy to benefit from ... BioMEMS: “In Yole Développement’s May 2015 Status of the ... will grow sharply and reach $6.6B in 2020,” says ... Yole Développement . , The analyst adds that ...
(Date:6/2/2015)... MI (PRWEB) June 02, 2015 Erbelli’s ... new website to promote its handmade gourmet pizzas and ... even though the website is new, the recipes are ... since 1995. The main feature of the site is ... appetizing pictures and descriptions of all the items. You ...
Breaking Medicine News(10 mins):Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 3Health News:UCLA Health Partners With Exer - More Than Urgent Care 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 3Health News:Tronics Aims to Benefit from Major Growth of Sensors and Related Technologies for Healthcare Applications 2Health News:Erbelli’s of Bradenton Launches New Mobile-Friendly Website 2
... 4 million men in the United States have low ... include erectile dysfunction, reduced muscle mass, reduced bone density, ... to increase testosterone levels for men with the condition. ... gel, or tablet. New research shows testosterone replacement therapy ...
... of osteoporosis. Such a break can lead to acute and ... to a recent study , it was found that the ... effective in reducing the risk for a vertebral fracture, according ... can reduce the risk of breaking a bone in the ...
... migraine headaches may be at risk for brain // lesions ... tissue has died. ,Researchers studied nearly 400 randomly ... into categories of having migraines with visual difficulties and having ... included in the study. Participants had a brain magnetic resonance ...
... shows only 7 percent of diabetics take the ... blood vessel problems. Researchers stressed continued negligence by ... retinopathy, neuropathy, nephropathy, coronary heart disease, stroke, and ... adults, ages 20 years or older, who had ...
... risk factors for melanoma skin cancer.// Previous research also shows ... detected early. ,New research shows patients who use photographs ... keep better track of new or changed moles. Researchers in ... atypical nevi, or pigmented moles that may change shape or ...
... age a person develops asthma may help explain their disease ... with asthma as children // have a different disease than ... patients suffered different symptoms and disease progression based on the ... that could not be controlled by steroids participated in the ...
Cached Medicine News:Health News:Onset Linked To Severity of Asthma 2
(Date:6/2/2015)... 2015 Stoltenberg Consulting , a ... announced the celebration of its 20-year anniversary and ... since its inception in 1995. ... the healthcare technology industry continues, we strive to ... to facilitating clients, organizational goals, understanding that today,s ...
(Date:6/2/2015)... their reach nationally by providing customers with on-site 17025 accredited pipette calibrations. ... ... ... ... Photo - http://photos.prnewswire.com/prnh/20150601/219758 As an industry-leading ...
(Date:6/2/2015)...  Ashion™ Advanced Individual Medicine™ (AIM), a ... industry, announced today the launch of its ... Medicine Platform. AIM develops and manages comprehensive ... healthcare systems, providing these centers with clinical ... operational support. AIM will use Syapse,s precision ...
Breaking Medicine Technology:Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 2Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 2Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 4Ashion Advanced Individual Medicine Chooses Syapse to Enable Genomics-Based Cancer Care in the Community 2Ashion Advanced Individual Medicine Chooses Syapse to Enable Genomics-Based Cancer Care in the Community 3
... Services Holdings Limited (the "Company" or "Concord Medical") (NYSE: ... of radiotherapy and diagnostic imaging centers in China, today ... of shareholders held in Beijing on November 26, 2011. ... "THAT Article 82(a) of the Articles of Association of ...
... -- Global Information, Inc. presents " Polycystic Ovarian ... to 2018 "  by GlobalData. (Photo:  ... a common chronic disorder of the endocrine system in ... years old) and is thought to be one of ...
Cached Medicine Technology:Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 2Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 3Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 4Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 5Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 6GiiResearch.com: Polycystic Ovarian Syndrome (PCOS) Therapeutics - Market to Witness Static Growth Until 2018 2GiiResearch.com: Polycystic Ovarian Syndrome (PCOS) Therapeutics - Market to Witness Static Growth Until 2018 3
Standard 20x long working distance objectives for greater magnifications of your microtools....
... An economical laboratory tissue culture microscope, the ... expand their applications. Olympus has taken the ... CKX41. Fluorescence can be used with an ... can be carried out on the CKX41 ...
... Eclipse TE2000S is an advanced ... research. It's exclusive CFI60 optical ... high numerical aperatures and longer ... inverted microscope to take full ...
... new Eclipse TS-100 is an innovative ... high quality tool complements any research ... CFI60 optics offer brilliant, sharp ... superb optical performance with high resolution ...
Medicine Products: