Navigation Links
Immune system activated in schizophrenia
Date:11/18/2009

Researchers at the Swedish medical university Karolinska Institutet have discovered that patients with recent-onset schizophrenia have higher levels of inflammatory substances in their brains. Their findings offer hope of being able to treat schizophrenia with drugs that affect the immune system.

The causes of schizophrenia are largely unknown, and this hinders the development of effective treatments. One theory is that infections caught early on in life might increase the risk of developing schizophrenia, but to date any direct evidence of this has not been forthcoming.

Scientists at Karolinska Institutet have now been able to analyse inflammatory substances in the spinal fluid of patients with schizophrenia, instead of, as in previous studies, in the blood. The results show that patients with recent-onset schizophrenia have raised levels of a signal substance called interleukin-1beta, which can be released in the presence of inflammation. In the healthy control patients, this substance was barely measurable.

"This suggests that the brain's immune defence system is activated in schizophrenia," says Professor Gran Engberg, who led the study. "It now remains to be seen whether there is an underlying infection or whether the immune system is triggered by some other means."

According to the dominant hypothesis, schizophrenia is related to an overactive dopamine system. Previous studies have shown that interleukin-1beta can upset the dopamine system in rats in a similar way to schizophrenia in humans.

"We would have made terrific progress if we were one day able to treat schizophrenia patients with immunotherapy, as it might then be possible to interrupt the course of the disease at an early stage of its development," says Professor Engberg.

The group is now studying if the inflammatory process is only activated in connection with the development of schizophrenia, or whether chronic patients exhibit the same
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MedImmune Announces Winners of the 4th Respiratory, Immunology and Autoimmunity Research Abstract Competition
2. Quick Defense(R) by Gaia Herbs Offers Research-Based, Patent-Pending Technology for a Fast Response in Supporting the Immune System
3. Smokers with common autoimmune disorder at higher risk for skin damage
4. MedImmune to present 4 abstracts on RSV and influenza at 47TH Annual IDSA Meeting
5. New Quick and Convenient Emergen-C(R) Shot Gives Immune Systems a Fighting Chance This Fall
6. Household Insecticides May Be Linked to Autoimmune Diseases
7. MedImmune to present data on RSV and influenza at 2009 AAP National Conference and Exhibition
8. Elderly immune system needs a boost
9. Immune Deficiency Foundation Among the First Rare Disease Patient Organizations to Launch Major Social Networking Initiatives
10. Strengthening Immune System in Time for Cold and Flu Season
11. Using Your Immune System to Fight Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... , ... August 31, 2015 , ... The dental implant ... according the American Academy of Implant Dentistry. (See Press Room ) More than ... require an implant procedure. With the increasing demand for dental implants, the National Association ...
(Date:8/31/2015)... Angeles, California (PRWEB) , ... August 31, 2015 ... ... pilot by host/actor/writer/director/ CSUN psychology professor Luciana Lagana (aka Dr. Luciana) received ... Awards, for Best Web Series, Best Documentary, and Best (Dis)ability Film. Dr. Luciana ...
(Date:8/31/2015)... ... August 31, 2015 , ... People with hostile personality traits ... for injury, potentially because they are more susceptible to the influence of television ... Health analysis discovered. , The research, published online in the International Journal ...
(Date:8/31/2015)... ... August 31, 2015 , ... The ... September by sharing the facts about the role of heredity in below-the-belt gynecologic ... mutations because of Angelina Jolie Pitt’s decisions to have both her breasts and ...
(Date:8/31/2015)... ... August 31, 2015 , ... Move over shave cream. Roll over ... barbershops are scrambling to meet it. , Reports published this year (Mintel data) announced ... But the data also reflects that men are getting more done at barbershops than ...
Breaking Medicine News(10 mins):Health News:Dental Association Raises Awareness as Implant Industry Grows 2Health News:Dental Association Raises Awareness as Implant Industry Grows 3Health News:Dental Association Raises Awareness as Implant Industry Grows 4Health News:Actor/Writer/Director/Psychology Professor Luciana Lagana Receives Three Wins at the 2015 Global Independent Film Awards for the TV Pilot Dr. Luciana on Aging and Falling 2Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 2Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 3Health News:Foundation for Women’s Cancer Alerts Women to the Facts About the Role of Heredity in Gynecologic Cancers 2Health News:Foundation for Women’s Cancer Alerts Women to the Facts About the Role of Heredity in Gynecologic Cancers 3Health News:Foundation for Women’s Cancer Alerts Women to the Facts About the Role of Heredity in Gynecologic Cancers 4Health News:MENAJI Anti-Aging Eraser a New Sure-Fire Add-On Product for Barbershops 2Health News:MENAJI Anti-Aging Eraser a New Sure-Fire Add-On Product for Barbershops 3
... , THURSDAY, March 10 (HealthDay News) -- Most ... that surgeons should adjust for when they perform surgeries ... Previous studies have found that cerebral palsy patients ... hips, but this is the first study to find ...
... most children with severe cerebral palsy have starkly asymmetric ... surgeries of the pelvis, spine and surrounding structures are ... be published online on March 10 in the ... patients with cerebral palsy have reported asymmetry above the ...
... HealthDay Reporter , WEDNESDAY, March 9 (HealthDay News) -- ... get injections of a new insulin drug just three times a ... be confirmed in another phase of research, and it,s not clear ... this use. But those caveats aside, the study raises the ...
... Serena Gordon HealthDay Reporter , WEDNESDAY, March 9 ... blood pressure may also help protect the kidneys of people ... caveat. In a new study, an international team ... name Benicar, could increase the time before any kidney problems ...
... team of researchers at Brigham and Womens Hospital (BWH) ... adult smokers have abnormal lung densities present on chest ... which is associated with substantial reductions in lung volumes. ... these lung densities were inversely not associated with emphysema. ...
... Neurological Institute has received a $10.1 million donation, the ... of the biggest ever given to any Arizona hospital. ... Rochelle to St. Joseph,s Barrow Neurological Institute in Phoenix ... for psychiatric and motor disorders by using novel treatments ...
Cached Medicine News:Health News:Hopkins Children's study finds some patients with cerebral palsy have asymmetric pelvic bones 2Health News:New Drug May Trim Insulin Injections to Just 3 a Week 2Health News:Blood Pressure Drug Delays Kidney Disease in Diabetics 2Health News:Blood Pressure Drug Delays Kidney Disease in Diabetics 3Health News:Researchers find smoking may increase risk for lung disease 2Health News:Deep brain stimulation research expands at Barrow 2Health News:Deep brain stimulation research expands at Barrow 3
(Date:8/31/2015)... Calif. , Aug. 31, 2015  Regulatory ... and government, where regulations are often strict and ... is driving a demand for professionals who have ... these regulations across a product lifecycle and demonstrate ... The University of California, Irvine Extension , ...
(Date:8/31/2015)... , August 31, 2015 ... (TASE: BOLT, OTCQX: BLGTY) ("BioLight" or the "Company"), ... biomedical innovations in ophthalmology and cancer diagnostics, today ... (TASE: MCTC), has identified several new genetic markers ... jawbone in patients treated with bisphosphonate drugs and ...
(Date:8/31/2015)... Premune and Innovet ... licensing agreement for Redonyl ® Ultra. The product, ... veterinary dermatology market, is a nutritional supplement based on ... in dogs and cats. Redonyl ® Ultra is ... has been received positively in the country by veterinarians ...
Breaking Medicine Technology:UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 2UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 3BioLight Reports Positive Clinical Study Results for Identifying New Genetic Markers to Predict Risk of Developing BRONJ 2BioLight Reports Positive Clinical Study Results for Identifying New Genetic Markers to Predict Risk of Developing BRONJ 3BioLight Reports Positive Clinical Study Results for Identifying New Genetic Markers to Predict Risk of Developing BRONJ 4Premune Broadens Portfolio With Novel Innovet Skin Health Product 2Premune Broadens Portfolio With Novel Innovet Skin Health Product 3Premune Broadens Portfolio With Novel Innovet Skin Health Product 4
... Plus, Higher then Expected MCI Prevalence Shows Urgent ... Two studies related to,experimental Alzheimer,s therapies reported ... Conference on Alzheimer,s,Disease (ICAD 2008) in Chicago., ... AL-108, targeted early,abnormal brain changes in a protein ...
... July 28 Cardium Therapeutics,(Amex: CXM ) ... as Chief,Medical Officer to lead the Company,s late-stage ... the MATRIX Phase 2b,clinical study that is evaluating ... ulcers, and the AWARE Phase 3 clinical study ...
Cached Medicine Technology:Two New Alzheimer's Disease Studies Show Advances Against Different Treatment Targets 2Two New Alzheimer's Disease Studies Show Advances Against Different Treatment Targets 3Two New Alzheimer's Disease Studies Show Advances Against Different Treatment Targets 4Two New Alzheimer's Disease Studies Show Advances Against Different Treatment Targets 5Two New Alzheimer's Disease Studies Show Advances Against Different Treatment Targets 6Cardium Announces Appointment of Paul A. Foster, M.D. to Lead Generx and Excellarate Late-Stage Development Activities 2Cardium Announces Appointment of Paul A. Foster, M.D. to Lead Generx and Excellarate Late-Stage Development Activities 3Cardium Announces Appointment of Paul A. Foster, M.D. to Lead Generx and Excellarate Late-Stage Development Activities 4Cardium Announces Appointment of Paul A. Foster, M.D. to Lead Generx and Excellarate Late-Stage Development Activities 5
... with Tim™ (Total imaging matrix) technology ... and highest resolution at 3T. With ... advanced applications can now be translated ... with Tim is an excellent dual-purpose ...
... Billing Assistant (MBA) is a ... and practice management software package. ... SQL Server technology and is ... and account receivable management, MBA ...
... a practice management system. DAQbilling files all ... Your patient statements can also be printed and ... traditional software and billing services into one software ... anywhere - multiples offices or home. ...
... G-3 goniofundus lens incorporate 3 mirrors angled at ... ideal for anterior chamber as well as central ... retinal viewing mirrors are accurately angled and spaced ... fundus. The central portion of the lens ...
Medicine Products: