Navigation Links
Immune responses to tetanus vaccine unchanged for RA patients on rituximab
Date:1/6/2010

Researchers from Johns Hopkins University determined that immune responses to the tetanus vaccine were not changed when rituximab in combination with methotrexate (MTX) was compared with MTX alone in patients with rheumatoid arthritis (RA). Responses to a pneumococcal vaccination (Pneumovax pneumonia vaccine), however, were reduced in RA patients with rituximab. Complete findings of this study are published in the January 2010 issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology.

According to the Centers for Disease Control and Prevention (CDC), RA affects 1.3 million adults in the U.S. (2005). RA patients may be at an increased risk of infection because of impaired immune function due to the disease as well as from the use of immunsuppressive medications. As a result, vaccinations against infections are an essential part of rheumatic disease management. How immunosuppressive agents alter the effectiveness of vaccines in RA patients was the focus of the clinical trial led by Clifton O. Bingham III, M.D.

The controlled study enrolled 103 RA patients from 26 centers in the U.S. between January 2006 and December 2007. Patients treated with a stable dose (10-25 mg/week) of MTX were randomly allocated to two groups: placebo and treatment with rituximab (2 x 1000 mg given two weeks apart). Both groups were immunized with the tetanus and pneumococcal vaccines along with keyhole limpet hemocyanin (KLH) to evaluate humoral immunity and skin tested with Candida albicans to evaluate the cellular immune response.

Results indicate that 39.1% of patients in the rituximab+MTX group and 42.3% of MTX-only patients demonstrated a 4-fold rise in the anti-tetanus IgG titer. A 2-fold rise was confirmed in 54.7% of rituximab-treated patients and 61.5% of subjects on MTX alone. The research demonstrates that RA patients given a tetanus vaccine responded the same to tetanus vaccination regardless of whether th
'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... GA (PRWEB) July 31, 2014 Developer ... camera on its Ponce City Market project in ... historic Sears, Roebuck & Company building into best-in-class office, ... completion, OxBlue reviewed Jamestown’s experience with their construction webcam ... , Jamestown wanted a construction camera ...
(Date:7/31/2014)... Lake Leelanau, MI (PRWEB) July 31, 2014 ... doors on Thursday, July 3, 2014 at 7788 East Horn ... Leelanau Peninsula Wine Trail , Aurora Cellars is the ... all trail activities including the popular wine tour events, making ... and Sunday, September 6-7, 2014. , Owners David and ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 In today’s world, ... difficult to get. Snoring and sleep apnea (a medical problem ... people and their bed partners of the rest they need ... of the population snores and 20 million people in the ... have been diagnosed and treated; and of those treated, many ...
(Date:7/31/2014)... 2014 Ce-Classes.com has announced that they ... healthcare professionals, a Systematic Review of Sexual Satisfaction ... in the International Journal of Clinical and Health Psychology. ... to a need to have accurate information about sexual ... treatment possible. The material provides a systematic review ...
(Date:7/31/2014)... In many states and counties across the country, ... life saving drugs. This requirement is for the safety of ... number of ambulances without proper security procedures. , In extreme ... even replaces the vital pain killers with saline. Later, the ... case in Baraboo, Wisconsin last November. According to court documents, ...
Breaking Medicine News(10 mins):Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 2Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 3Health News:Aurora Cellars Joins the Leelanau Peninsula Wine Trail 2Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Company Provides New Course on Sexual Satisfaction 2Health News:Company Provides New Course on Sexual Satisfaction 3Health News:New MedixSafe Alert - Ambulances Must Have A Medical Safe, Narcotics Cabinet, or Drug Locker 2
... By Jenifer Goodwin HealthDay Reporter ... experimental drug reduced two signature characteristics of autism ... in laboratory mice, new research finds. The ... throughout the brain that,s involved with activating neurons, ...
... become known as "pink slime" actually seemed like a triumph of ... and, at one point, even got rave reviews in the news ... Chemical & Engineering News . C&EN is the weekly ... In the article, Carmen Drahl, C&EN associate editor, ...
... the stomachs of pigs could be a long-sought, abundant source ... to supplement baby formula and for use in personal hygiene ... viral infections. Their study appears in ACS, journal Biomacromolecules ... out that mucus, which coats the inside of the nose, ...
... France, 19 April 2012: The European Society of Cardiology ... Heart Journal: Acute Cardiovascular Care , the organisation,s official ... Care. "This new journal will be an ... professionals, offering useful information for daily clinical practice to ...
... HealthDay Reporter , TUESDAY, April 24 (HealthDay News) -- After ... least one state may finally be turning things around. ... 6 in eastern Massachusetts declined during the period between 2004 ... also found that the rates of obesity declined more for ...
... Together with child and adolescent psychiatrists, researchers from the University ... the studies which have been done so far on the ... The report shows that there are potential benefits in changing ... in the area is still lacking. The comprehensive report ...
Cached Medicine News:Health News:Experimental Drug Eases Autistic Behaviors in Mice 2Health News:Experimental Drug Eases Autistic Behaviors in Mice 3Health News:Experimental Drug Eases Autistic Behaviors in Mice 4Health News:Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC 2Health News:Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC 3Health News:Could the Childhood Obesity 'Epidemic' Be Ebbing? 2Health News:Could the Childhood Obesity 'Epidemic' Be Ebbing? 3Health News:Dietary changes help some children with ADHD 2
(Date:7/31/2014)... Calif., July 31, 2014 STAAR Surgical Company ... and marketer of implantable lenses and delivery systems for ... ended July 4, 2014 of $20.0 million, a 10% ... of 2013. On a constant currency basis, revenues grew ... the second quarter of 2013.  The effect of foreign ...
(Date:7/31/2014)... 31, 2014 Tandem Diabetes Care®, Inc. (NASDAQ: ... the t:slim® Insulin Pump, today reported its financial results for ... comparing the second quarter of 2014 to the same period ... million from $5.5 million , t:slim Pump shipments grew ... In comparing six months ended June 30, 2014 to the ...
(Date:7/31/2014)... -- Cepheid (NASDAQ: CPHD ) today announced that its ... investors to participate via webcast. Wedbush ... Wednesday, August 13, 2014 at 9.10 a.m. Eastern ... New York, NY Thursday, September 4, 2014 at ... To access the live webcasts for these events, please visit ...
Breaking Medicine Technology:STAAR Surgical Reports 10% Second Quarter Revenue Growth 2STAAR Surgical Reports 10% Second Quarter Revenue Growth 3STAAR Surgical Reports 10% Second Quarter Revenue Growth 4STAAR Surgical Reports 10% Second Quarter Revenue Growth 5STAAR Surgical Reports 10% Second Quarter Revenue Growth 6STAAR Surgical Reports 10% Second Quarter Revenue Growth 7STAAR Surgical Reports 10% Second Quarter Revenue Growth 8STAAR Surgical Reports 10% Second Quarter Revenue Growth 9STAAR Surgical Reports 10% Second Quarter Revenue Growth 10STAAR Surgical Reports 10% Second Quarter Revenue Growth 11STAAR Surgical Reports 10% Second Quarter Revenue Growth 12STAAR Surgical Reports 10% Second Quarter Revenue Growth 13STAAR Surgical Reports 10% Second Quarter Revenue Growth 14STAAR Surgical Reports 10% Second Quarter Revenue Growth 15STAAR Surgical Reports 10% Second Quarter Revenue Growth 16STAAR Surgical Reports 10% Second Quarter Revenue Growth 17STAAR Surgical Reports 10% Second Quarter Revenue Growth 18STAAR Surgical Reports 10% Second Quarter Revenue Growth 19STAAR Surgical Reports 10% Second Quarter Revenue Growth 20STAAR Surgical Reports 10% Second Quarter Revenue Growth 21STAAR Surgical Reports 10% Second Quarter Revenue Growth 22STAAR Surgical Reports 10% Second Quarter Revenue Growth 23STAAR Surgical Reports 10% Second Quarter Revenue Growth 24STAAR Surgical Reports 10% Second Quarter Revenue Growth 25STAAR Surgical Reports 10% Second Quarter Revenue Growth 26STAAR Surgical Reports 10% Second Quarter Revenue Growth 27STAAR Surgical Reports 10% Second Quarter Revenue Growth 28STAAR Surgical Reports 10% Second Quarter Revenue Growth 29STAAR Surgical Reports 10% Second Quarter Revenue Growth 30STAAR Surgical Reports 10% Second Quarter Revenue Growth 31Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 3Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 4Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 5Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 6
... flexible lighting products. The first is available ... sizes 5", 10", and 15" (refers to ... These lights are for use in procedures ... second group of flexible lights is our ...
These units, though small, still offer sufficient output to ensure current is fully adjustable from 0 to 70 mA. Instruction manual, ball electrodes, battery and leads with alligator clips are include...
These units, though small, still offer sufficient output to ensure current is fully adjustable from 0 to 70 mA. Instruction manual, ball electrodes, battery and leads with alligator clips are include...
... Modes of Operation: , Standby: A standby switch ... , Double Burst : 2 60-ms bursts of 50 ... , Twitch: 1 s (1 pulse/s); 2 Hz (2 ... 100 Hz (100 pulses/s) , Train-Of-Four: 4 pulses/2 s; ...
Medicine Products: