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Immune reaction to metal debris leads to early failure of joint implants
Date:3/4/2009

danger signals are detected by large complexes of proteins, called inflammasomes. The inflammasomes mobilize, precipitating a chain of chemical events that cause inflammation.

The researchers are hopeful that identification of this molecular pathway that triggers inflammation without infection could lead to new and specific therapeutic strategies to avoid the early failure of joint replacements.

Other researchers at Rush involved in the study were Marco Caicedo, Ronak Desai, Kyron McAllister, Dr. Anand Reddy, and Dr. Joshua Jacobs.


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Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

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