Navigation Links
Immune reaction to metal debris leads to early failure of joint implants

Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.

The study, funded by the National Institutes of Health, won the annual William H. Harris, MD Award for scientific merit from the Orthopaedic Research Society. Currently posted online, it is expected to be published in the June issue of the Journal of Orthopaedic Research.

Over 600,000 total joint replacements are performed in the United States each year. The vast majority are successful and last well over 10 years. But in up to 10 percent of patients, the metal components loosen, requiring the patient to undergo a second surgery.

The loosening is often caused by localized inflammation, an immune reaction to tiny particles of debris from the components themselves as they rub against one another. No infection is involved.

"As soon as joint replacement devices are implanted, they begin to corrode and wear away, releasing particles and ions that ultimately signal danger to the body's immune system," said Nadim Hallab, associate professor at Rush University Medical Center and the study author.

There are two different types of inflammatory pathways: one that reacts to foreign bodies like bacteria and viruses, which cause an infection, and another that reacts to "sterile" or non-living danger signals, including ultraviolet light and oxidative stress.

This is the first time that researchers have shown that debris and ions from implants trigger this danger-signaling pathway.

According to Hallab, when specialized cells of the immune system, called macrophages, encounter this metallic debris, they "engulf it in sacs called lysosomes and try to get rid of the debris by digesting it with enzymes." But the particles damage the lysosomes, Hallab said, "and the cells start screaming 'danger.'"

These danger signals are detected by large complexes of proteins, called inflammasomes. The inflammasomes mobilize, precipitating a chain of chemical events that cause inflammation.

The researchers are hopeful that identification of this molecular pathway that triggers inflammation without infection could lead to new and specific therapeutic strategies to avoid the early failure of joint replacements.

Other researchers at Rush involved in the study were Marco Caicedo, Ronak Desai, Kyron McAllister, Dr. Anand Reddy, and Dr. Joshua Jacobs.


Contact: Sharon Butler
Rush University Medical Center

Related medicine news :

1. Varicella zoster infection causes severe autoimmune hepatitis
2. Frost & Sullivan Lauds Aesku.Diagnostics For Providing an Overall Analysis Platform For a Wide Range of Autoimmune Complications
3. Genetic evidence points to potential therapeutic bypass for autoimmune process
4. German Medical Advancement Reflects Major Improvement in Individuals with Common and Chronic Illnesses Related to Immune System Dysfunction
5. The Journal of Nutrition Publishes Study Indicating that AHCC(R) Provides Immune Support against West Nile Virus
6. Team learns how cellular protein detects viruses and sparks immune response
7. FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve
8. Immune Cells Shrink Tumors in Mice
9. Genes Help Cancer-Linked Viruses Elude Immune System
10. Landmark Rh Immune Globulin Celebrates 40 Years of Saving Babies Lives
11. 2 immune-system proteins linked to colitis-associated cancer
Post Your Comments:
(Date:11/30/2015)... ... , ... GKhair & Tibolli team members and artists were excited and proud ... 8th and 9th at the Puerto Rico Convention Center, San Juan Puerto Rico. The ... of the line fashion journalists. The San Juan Beauty Show carries immense credibility among ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... professionals worldwide today released the results of a survey of educational needs for ... Africa found a growing global demand for high quality online and face-to-face education ...
(Date:11/30/2015)... ... 2015 , ... Workstation solutions provider , HealthPostures, announces ... located throughout the United States, is OneStop Ergonomics. The addition allows HealthPostures to ... government workers and organizational leaders that are introduced to innovative methods that could ...
(Date:11/30/2015)... , ... November 30, 2015 , ... Bayco Products, Inc today announced the introduction of ... Available in a choice of three different colors; red ( NSP-1632 ), yellow ( NSP-1634 ... up to 18 hours in constant-on mode, or 27 hours in blinking strobe mode using ...
(Date:11/29/2015)... , ... November 29, 2015 ... ... accredited by the American Institute of Ultrasound in Medicine! , AIUM ultrasound ... demonstrate that they meet or exceed nationally recognized standards in the performance ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Elbit Imaging Ltd. (TASE, NASDAQ: ... that it was informed by InSightec Ltd. ("InSightec"), that the ... approved its Exablate Neuro system to treat movement, pain ... --> Insightec,s Exablate Neuro platform is transforming medicine ... technologies: Focused Ultrasound, which is used to lesion the ...
(Date:11/29/2015)... Health Cloud 1 was unveiled today at the 101 ... (RSNA) meeting in Chicago . ... and its applications will connect radiologists and clinicians to speed, ... both inside and outside the hospital setting. ... digital industrial leader, we are betting big on the GE ...
(Date:11/27/2015)... , Niederlande, November 27, 2015 ... fotodynamischer Bremachlorin-Therapie bei fortgeschrittenem Krebs.   --> ... Bremachlorin-Therapie bei fortgeschrittenem Krebs.   --> ... Bremachlorin-Therapie bei fortgeschrittenem Krebs.   Clinical ... --> Clinical Cancer Research vom ...
Breaking Medicine Technology: