Navigation Links
Immune reaction to metal debris leads to early failure of joint implants
Date:3/4/2009

Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.

The study, funded by the National Institutes of Health, won the annual William H. Harris, MD Award for scientific merit from the Orthopaedic Research Society. Currently posted online, it is expected to be published in the June issue of the Journal of Orthopaedic Research.

Over 600,000 total joint replacements are performed in the United States each year. The vast majority are successful and last well over 10 years. But in up to 10 percent of patients, the metal components loosen, requiring the patient to undergo a second surgery.

The loosening is often caused by localized inflammation, an immune reaction to tiny particles of debris from the components themselves as they rub against one another. No infection is involved.

"As soon as joint replacement devices are implanted, they begin to corrode and wear away, releasing particles and ions that ultimately signal danger to the body's immune system," said Nadim Hallab, associate professor at Rush University Medical Center and the study author.

There are two different types of inflammatory pathways: one that reacts to foreign bodies like bacteria and viruses, which cause an infection, and another that reacts to "sterile" or non-living danger signals, including ultraviolet light and oxidative stress.

This is the first time that researchers have shown that debris and ions from implants trigger this danger-signaling pathway.

According to Hallab, when specialized cells of the immune system, called macrophages, encounter this metallic debris, they "engulf it in sacs called lysosomes and try to get rid of the debris by digesting it with enzymes." But the particles damage the lysosomes, Hallab said, "and the cells start screaming 'danger.'"

These
'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Varicella zoster infection causes severe autoimmune hepatitis
2. Frost & Sullivan Lauds Aesku.Diagnostics For Providing an Overall Analysis Platform For a Wide Range of Autoimmune Complications
3. Genetic evidence points to potential therapeutic bypass for autoimmune process
4. German Medical Advancement Reflects Major Improvement in Individuals with Common and Chronic Illnesses Related to Immune System Dysfunction
5. The Journal of Nutrition Publishes Study Indicating that AHCC(R) Provides Immune Support against West Nile Virus
6. Team learns how cellular protein detects viruses and sparks immune response
7. FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve
8. Immune Cells Shrink Tumors in Mice
9. Genes Help Cancer-Linked Viruses Elude Immune System
10. Landmark Rh Immune Globulin Celebrates 40 Years of Saving Babies Lives
11. 2 immune-system proteins linked to colitis-associated cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (HealthDay News) -- Elementary school students seem to be satisfied ... to a new study of school officials. , , New ... -- went into effect in the fall of 2012. At ... lunch, or throw away most of their food. But the ... isn,t the case. , , "The updated meals standards are ...
(Date:7/28/2014)... 28, 2014 Thousands of DePuy Pinnacle ... of individuals who were allegedly injured by a metal-on-metal ... move forward in U.S. District Court, Northern District of ... issued on July 18, 2014, U.S. District Judge Ed ... the Plaintiffs’ Steering Committee that sought the deposition of ...
(Date:7/28/2014)... Cape Regional Medical Center, is currently ... solution in an effort to streamline its bi-directional ... their New Jersey health information exchange (NJSHINE). , ... New Jersey, serves the local population and more ... inpatient and outpatient services. With a strong commitment ...
(Date:7/28/2014)... chronic medical conditions people have at retirement age, the ... claims. Since nearly four in five older ... Bloomberg School of Public Health in Baltimore said the ... are slowing in the United States. "Living with ... heart failure is now the norm and not the ...
(Date:7/28/2014)... HealthDay Reporter MONDAY, July 28, 2014 ... irregularities are more likely to get a pacemaker than people ... study of more than 16,000 people found that those with ... a pacemaker than those without the memory-robbing condition. ... dementia are so much more likely to be treated with ...
Breaking Medicine News(10 mins):Health News:Healthy School Lunches Get Thumbs Up From Students 2Health News:DePuy Pinnacle Lawsuit News: New Order Issued in Federal Pinnacle Hip Implant Litigation, Bernstein Liebhard LLP Reports 2Health News:DePuy Pinnacle Lawsuit News: New Order Issued in Federal Pinnacle Hip Implant Litigation, Bernstein Liebhard LLP Reports 3Health News:DePuy Pinnacle Lawsuit News: New Order Issued in Federal Pinnacle Hip Implant Litigation, Bernstein Liebhard LLP Reports 4Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 2Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 3
... , CHICAGO, Sept. 1 Controlling healthcare costs ... economic model to save our nation billions of dollars. , , ... answer, according to Jason Beans, CEO of Chicago-based Rising Medical Solutions ... change exists in a different direction. , , "People ...
... , Study is one of the first ... imaging techniques , , ... today announced the findings of a scientific study that used brain ... because it increases gray matter. Over a three-month period, adolescent girls ...
... , MORRISTOWN, N.J., Sept. 1 Prostate ... United States. In fact one in six men will face prostate cancer ... focus on an ongoing effort by Major League Baseball pitchers John ... of the Atlanta Braves, who are spreading the word about prostate cancer ...
... , KENILWORTH, N.J., Sept. 1 Schering-Plough Corporation (NYSE: ... the only 12-hour allergy medicine found in the allergy aisle. New ... the worst indoor and outdoor allergy symptoms. The product is ... , (Photo: http://www.newscom.com/cgi-bin/prnh/20090901/NY68186 ) ...
... , , , ... The maturity of the U.S. compression therapy market is ... plateau. Manufacturers are using the concept of evidence-based medicine to ... health awareness among consumers has spurred the demand for early ...
... VidaGas propane energy company secures $1.4M investment ... FRANCISCO, Sept. 1 VillageReach, the Seattle-based social enterprise that ... the Foundation for Community Development (FDC), a Mozambique non profit ... the Oasis Fund, a European commercial investment fund specializing in ...
Cached Medicine News:Health News:Five Ways to Change America's Healthcare System: 2Health News:Brain Imaging Shows Playing Tetris Leads to Both Brain Efficiency and Thicker Cortex 2Health News:Brain Imaging Shows Playing Tetris Leads to Both Brain Efficiency and Thicker Cortex 3Health News:Brain Imaging Shows Playing Tetris Leads to Both Brain Efficiency and Thicker Cortex 4Health News:Brain Imaging Shows Playing Tetris Leads to Both Brain Efficiency and Thicker Cortex 5Health News:Major League Baseball Pitchers John Smoltz and Derek Lowe Help Raise Awareness Throughout Prostate Cancer Awareness Month 2Health News:Major League Baseball Pitchers John Smoltz and Derek Lowe Help Raise Awareness Throughout Prostate Cancer Awareness Month 3Health News:Major League Baseball Pitchers John Smoltz and Derek Lowe Help Raise Awareness Throughout Prostate Cancer Awareness Month 4Health News:New Non-Drowsy CLARITIN(R) 12-Hour Gets Allergy Sufferers Through Their Busy Day 2Health News:New Non-Drowsy CLARITIN(R) 12-Hour Gets Allergy Sufferers Through Their Busy Day 3Health News:U.S. Compression Therapy Market to Reach $1.16 Billion in 2015, Finds Frost & Sullivan 2Health News:U.S. Compression Therapy Market to Reach $1.16 Billion in 2015, Finds Frost & Sullivan 3Health News:U.S. Compression Therapy Market to Reach $1.16 Billion in 2015, Finds Frost & Sullivan 4Health News:VillageReach, Foundation for Community Development and Oasis Fund Announce Strategic Investment in Mozambique Social Business 2Health News:VillageReach, Foundation for Community Development and Oasis Fund Announce Strategic Investment in Mozambique Social Business 3Health News:VillageReach, Foundation for Community Development and Oasis Fund Announce Strategic Investment in Mozambique Social Business 4
(Date:7/28/2014)... /PRNewswire-iReach/ -- June 28 th , 2014 – Oncolab, the ... AMAS cancer test, is making its AACC debut (booth #4051) ... which is a serum-based in vitro immunoassay, has been run ... tool in the fight against cancer recurrence. Photo ... 17 million cancer survivors in the US alone, the race ...
(Date:7/28/2014)... , July 28, 2014  Air Products (NYSE: ... of medical oxygen is vital to any healthcare facility. ... that not only improve the efficiency of its oxygen ... will highlight these systems—including systems for emergency oxygen ... loss—from August 4-5 at the 51 st ...
(Date:7/28/2014)... 28, 2014 Research and Markets  has announced ... 2014-2018" report to their offering. ... that leads to inflammation and pain in the human body,s ... addition, it causes inflammation of the tissues that surround the ... symptoms of RA begin slowly, usually just mild pain around ...
Breaking Medicine Technology:Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Global Rheumatoid Arthritis Drugs Market 2014-2018 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: