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Immune cell's role in intestinal movement may lead to better understanding of IBS
Date:7/18/2014

a family of proteins thought to control organ development.

Blocking the effect of BMP2 mirrored the effects of the macrophage removal, confirming that the protein is used for regulation of intestinal movements. The BMP2 is used by neighboring nerve cells, intestinal neurons, which in turn secrete a protein called colony stimulatory factor 1 (CSF1) that supports macrophages.

"Two completely different cell types help each other to carry one key function, to regulate the physiology of the gut," Bogunovic said.

The interactions between the two cells types are orchestrated by the "good" bacteria in the intestine that aids in healthy digestion.

By giving mice antibiotics to kill off the bacteria, the communication between macrophages and neurons is interrupted resulting in decreased BMP2 and CSF1 production and disrupted intestinal contractions.

By restoring the "good" bacteria in the mice, the miscommunication between macrophages and neurons is reversed, showing that the dialogue between the macrophages and nervous system is adaptable to the changes in the bacterial environment.

A potential cause of IBS is a change in the bacterial environment in the intestine.

"By better understanding how the nervous system cells, the muscularis macrophages and signals from inside the intestine interact, we may be able to find new treatments for IBS, or even prevent it," Bogunovic said.


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Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2

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