Navigation Links
Immune cell's role in intestinal movement may lead to better understanding of IBS
Date:7/18/2014

Learning the role of immune-system cells in healthy digestive tracts and how they interact with neighboring nerve cells may lead to new treatments for irritable bowel syndrome (IBS). Researchers from Penn State College of Medicine, in collaboration with other scientists, have reported the role of macrophages in regulating the contractions of the colon to push digested material through the digestive tract.

The muscular lining of the intestine contains a distinct kind of macrophage, an immune system cell that helps fight infections. The role of these cells in normal colon function is not known, although they have been linked to inflammation after abdominal surgery.

"Very little is known about the function of muscularis macrophages, mainly because these cells are difficult to isolate from intestinal tissue," said Milena Bogunovic, assistant professor of microbiology and immunology.

Digested material is moved through the intestines by the contraction and relaxation of intestinal muscles. The pattern and frequency of these contractions are controlled by the signals from the intestinal nervous system. In patients with diseases like IBS, the signals are overactive and stimulation is exaggerated.

The researchers developed a method to deplete muscularis macrophages in the intestines of mice to determine their function. They report their findings in the journal Cell.

"After macrophage depletion, we observed that the normal intestinal movements are irregular, probably because the muscular contractions were poorly coordinated, suggesting that intestinal movements are regulated by macrophages," Bogunovic said.

After confirming the role of the macrophages in the function of the digestive tract, the researchers looked for how the regulation happens. They compared the genetic code of different types of macrophages to find non-immune genes highly active in muscularis macrophages, identifying bone morphogenetic protein 2. BMP2 is one of
'/>"/>

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2

Related medicine news :

1. How does the immune system fight off threats to the brain? New research yields fresh insight
2. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
3. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
4. Rutgers team discovers novel approach to stimulate immune cells
5. Scientists study serious immune malfunction
6. Babies susceptibility to colds linked to immune response at birth
7. Reactions to HIV drug have autoimmune cause, reports AIDS journal
8. First study to suggest that the immune system may protect against Alzheimers changes in humans
9. Belly Membrane May Regulate Immune System, Mouse Study Finds
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Researchers reveal crucial immune fighter role of the STING protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Slone Partners , a national recruitment firm ... and laboratory testing industries, has promoted Leslie Loveless ... announcement comes after a year of expansion by ... Boston and several new additions to the team. ... experience," said Adam Slone, Chief Executive Officer. “Diagnostics ...
(Date:12/19/2014)... Consilium Staffing, Your Partner in Locum ... Federal Health Professionals annual meeting in Washington, D.C., ... and federal healthcare providers. , In addition, ... Engagement (NVSBE) conference last week in Atlanta, Georgia. ... solution in addressing our nation’s shortage of physicians,” ...
(Date:12/19/2014)... Dec. 18, 2014 (HealthDay News) -- A new study ... moderate to severe hot flashes and night sweats -- ... Hot flashes are common during menopause, affecting about ... also affect women after menopause, since they then face ... "Our findings suggest women who exhibit moderate or severe ...
(Date:12/19/2014)... Randy Dotinga ... News) -- Common painkillers, including ibuprofen, might slightly reduce ... researchers say. Use of ibuprofen (Advil, Motrin) and ... cell skin cancer by 15 percent, the researchers concluded ... is usually caused by sun exposure. ...
(Date:12/19/2014)... HealthDay Reporter THURSDAY, Dec. 18, 2014 (HealthDay ... at least 20 seconds you may be at risk of ... leg may indicate that small strokes or tiny bleeds have ... is high, the investigators reported online Dec. 18 in the ... on one leg, as well as problems walking, should receive ...
Breaking Medicine News(10 mins):Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2Health News:Consilium Staffing Increasing Awareness of Locum Tenens through Conference Appearances 2Health News:Severe Hot Flashes During Menopause May Raise Hip Fracture Risk Later: Study 2Health News:Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds 2Health News:Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds 3Health News:Can You Balance on One Leg? You May Have Lower Stroke Risk 2
... The preoperative assessment of breast cancer patients for ... which serves to enable the early diagnosis and ... data from a five-year study published this week ... ( http://www3.interscience.wiley.com/cgi-bin/abstract/118821880/ABSTRACT ). , In a study ...
... Medical Systems,(AMEX: LMZ ; TSX:LMZ), a healthcare technology company ... obstetrics is pleased to announce,receiving a score of 88.8 ... the healthcare IT industry. LMS met the criteria to ... and is pleased to have received the,highest performance score ...
... designed to selectively weaken specific muscles may provide an ... attractive alternative treatment for frown lines, ... BFRM ) announced that it has acquired substantially ... Cosmetic Intervention,Inc. (ACI) and associated technology rights for $12 ...
... SpaBrite Teeth,Whitening System(TM) has introduced an FDA ... improves the look of discolored teeth. The company,created ... as,a natural addition to the spa experience. Now ... environment without compromising the effectiveness,of the treatment., ...
... Calif., April 29 The following,release was issued today ... United Healthcare Workers-West (UHW) and its allies,inside SEIU have ... and,retaliation, to reform our International Union., The most ... plans,to sue UHW leaders. UHW,s elected executive board members ...
... It,s "Cover the Uninsured Week," an,annual campaign ... 47 million,Americans who live without health insurance., ... (NYSE: PFE ) at:, http://media.medialink.com/WebNR.aspx?story=35042 , ... text, graphics and,photos for free and unrestricted ...
Cached Medicine News:Health News:Preoperative assessment of cancer patients enables early diagnosis, treatment of lymphedema 2Health News:LMS CALM(R) receives high customer satisfaction scores in the 2008 KLAS Labor and Delivery report 2Health News:LMS CALM(R) receives high customer satisfaction scores in the 2008 KLAS Labor and Delivery report 3Health News:BioForm Medical Acquires Facial Aesthetic Nerve Ablation Technology 2Health News:BioForm Medical Acquires Facial Aesthetic Nerve Ablation Technology 3Health News:BioForm Medical Acquires Facial Aesthetic Nerve Ablation Technology 4Health News:BioForm Medical Acquires Facial Aesthetic Nerve Ablation Technology 5Health News:Beautiful Teeth Not Just for the Dentist's Office Anymore / SpaBrite Teeth Whitening System(TM) Introduces Innovative, New Teeth Whitening Experience To Spas 2Health News:Statement by UHW President Sal Rosselli on SEIU Threat to Sue UHW Leaders 2
(Date:12/19/2014)... 2014  Sage Analytics ( www.sageanalytics.com ), the ... the testing of marijuana potency and moisture content, ... Profiler, the industry,s first product suite capable of ... portable unit. Designed from the ground ... cannabis industry, the Luminary™ Profiler utilizes specially purposed ...
(Date:12/19/2014)... Ky. , Dec. 18, 2014 Baptist Health ... States to receive full Atrial Fibrillation with Electrophysiology ... Care (SCPC). Atrial fibrillation is the most common ... that in some cases can lead to stroke and possible ... United States have atrial fibrillation and the numbers ...
(Date:12/19/2014)... robust development with the growth pace keeping at 20%-30% in ... the size of China separating membrane ... to 16.3%. It is projected that China ... around 20% in the upcoming years and that the figure ... An integrated membrane industrial system has taken shape in ...
Breaking Medicine Technology:Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3
... 16, the U.S. Supreme Court will hear arguments in an ... v. SmithKline Beecham Corp. The specific question in the ... overtime pay. The larger issue is the deference that is ... statute. The Fair Labor Standards Act and ...
... April 10, 2012 Mylan Inc. (Nasdaq: MYL ... and live webcast on Thursday, April 26, 2012, at 10:00 ... first quarter 2012, which ended March 31, 2012. Mylan will ... opens. The dial-in number to access the call ...
Cached Medicine Technology:Supreme Court to Decide Overtime Fate for Pharmaceutical "Sales Representatives" -- JacksonWhite, Kingsley & Kingsley and Sanford Wittels & Heisler 2Supreme Court to Decide Overtime Fate for Pharmaceutical "Sales Representatives" -- JacksonWhite, Kingsley & Kingsley and Sanford Wittels & Heisler 3
... the Streamline family of temporary sensing and ... gold standard in temporary pacing leads and ... easy to use and less traumatic to ... Pediatric Temporary Pacing Lead is designed for ...
VascoStim B 2/5F is a bipolar temporary pacing lead with a balloon. It can be placed easily by the resistance of the inflated balloon in the blood flow....
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
Medicine Products: