Navigation Links
Immune cells predict success of head and neck cancer treatment, U-M study finds
Date:4/26/2010

ANN ARBOR, Mich. Levels of a key type of immune cell are higher in head and neck cancer patients whose tumors are linked to the human papillomavirus, or HPV, according to researchers at the University of Michigan Comprehensive Cancer Center.

The finding suggests a way to predict which tumors are most likely to respond to chemotherapy and radiation and allow doctors to choose the best treatment option up front.

"In the past, we would give toxic chemotherapy to a patient, look at how the tumor responded and then decide whether the patient needed surgery or radiation. Now with patients who have HPV-positive cancers, this study suggests we can look in the microscope, measure the level of these immune cells and, based on that, select a treatment that is going to be potentially less toxic for the patient and most effective at curing the cancer," says study author Gregory T. Wolf, M.D., professor and chair emeritus of otolaryngology at the U-M Medical School.

Results of the study will be presented April 29 at the American Head and Neck Society annual meeting.

The researchers looked at 66 patients with oropharyngeal cancer, which includes cancers of the tonsils and the tongue base. They measured levels of several immune system cells in the blood and tracked HPV status.

The HPV-positive patients had higher levels of a subset of T-lymphocyte cells, a type of immune cell that is responsible for killing tumor cells. Patients who responded to an initial round of chemotherapy also had higher levels of these cells, while patients whose cancer recurred had lower levels.

"When we looked at how successful chemotherapy and radiation were, the levels of those killer T-lymphocyte cells predicted who was going to do well. That ability to predict response was even better than when we look at whether the tumors were HPV-positive or negative," says Wolf, director of the Head and Neck Cancer Specialized Program of Research Excellence at the U-M Comprehensive Cancer Center.

Previous studies have shown that HPV-positive head and neck cancers tend to be more responsive to current treatments, and these patients overall tend to have better outcomes than patients with HPV-negative tumors.

The researchers suggest that these new findings could help them devise strategies to boost the immune system of HPV-negative patients and improve the success rate of current therapies.

"We're actively pursuing how we can capitalize on this information and devise better immunotherapy approaches to head and neck cancer that would be less toxic than surgery or intensive radiation and hopefully cure more patients," Wolf says.

Head and neck cancer statistics: 35,720 Americans will be diagnosed with head and neck cancer this year and 7,600 will die from the disease, according to the American Cancer Society


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. Skin Condition Vitiligo Tied to Immune System Dysfunction
2. Immune sensors suppress colitis-associated cancer
3. Tumors hide out from the immune system by mimicking lymph nodes
4. Tumors Use a Protein to Hide From Immune System
5. Optimism May Boost Immune System
6. Researchers discover fundamental step in immune-system development
7. Optimism boosts the immune system
8. Go with Your Gut and Boost your Immune System with America's Favorite Fruit
9. Study Details Machinery of Immune Protection Against Inflammatory Diseases Like Colitis
10. Targeting blood vessels, immune system may offer way to stop infection-caused inflammation
11. New approach to immune cell analysis seen as first step to better distinguish health and disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune cells predict success of head and neck cancer treatment, U-M study finds
(Date:2/5/2016)... New York (PRWEB) , ... February 05, 2016 , ... ... The answer may be at the tips of your toes. Foot massage, whether administered ... well as pure comfort and relaxation. The American Board of Multiple Specialties in ...
(Date:2/5/2016)... Illinois (PRWEB) , ... February 05, 2016 , ... ... and independent PROSHRED franchises from across the country gathered at the La Valencia ... recognize top performers. PROSHRED Chicago was named the year’s most outstanding franchise, ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, ... in KLAS: Software & Services for HIT Implementation Support & Staffing report with ... ranks vendor performance by healthcare executives, managers and clinicians representing over 4,500 hospitals ...
(Date:2/5/2016)... CA (PRWEB) , ... February 05, 2016 , ... ... Move from on one drop zone to the next using Colorize's dynamic moving camera. ... any project. This package includes a 3D slideshow environment with 1 to 5 focus ...
(Date:2/5/2016)... ... February 05, 2016 , ... Calls Blacklist has just been updated by mobile ... and the developer has fixed known bugs within the app. Calls Blacklist allows its ... while not consuming any of their device’s battery power or memory. It provides a ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... the addition of the "Global Obstetrics ... company profile to their offering. ... addition of the "Global Obstetrics Partnering ... company profile to their offering. --> ...
(Date:2/4/2016)... 2016  The Senior Care Pharmacy Coalition (SCPC) ... Chairman Jason Chaffetz (R-UT) and Ranking ... hearing , "Developments in the Prescription Drug Market," ... questions about abusive pharmacy benefit manager (PBM) pricing ... Ranking Member Elijah Cummings (D-MD) are diligent, serious ...
(Date:2/4/2016)... Feb. 4, 2016  SciClone Pharmaceuticals, Inc. (NASDAQ: ... has entered into a settlement agreement with the ... resolving the SEC,s investigation into possible violations of ... terms of the settlement agreement, SciClone has agreed ... disgorgement, pre-judgment interest and a penalty.  This payment ...
Breaking Medicine Technology: